BP 404 T. PHARMACOLOGY-I (Theory)
... Scope: The main purpose of the subject is to understand what drugs do to the living organisms and how their effects can be applied to therapeutics. The subject covers the information about the drugs like, mechanism of action, physiological and biochemical effects (pharmacodynamics) as well as absorp ...
... Scope: The main purpose of the subject is to understand what drugs do to the living organisms and how their effects can be applied to therapeutics. The subject covers the information about the drugs like, mechanism of action, physiological and biochemical effects (pharmacodynamics) as well as absorp ...
Pharmacokinetics-Pharmacodynamics
... any better, but there will be more undesirable side effects. – If the amount is too low, it won’t have any beneficial effect. ...
... any better, but there will be more undesirable side effects. – If the amount is too low, it won’t have any beneficial effect. ...
Angiotensin II Increases Norepinephrine Release
... the heart, for instance, messenger RNA for the synthesis of renin has been detected, and a tissue-bound converting enzyme is also present, as well as Ang II, its precursor Ang I, and the metabolite angiotensin III. 3 5 Such a local renin-angiotensin system may be responsible for a variety of physiol ...
... the heart, for instance, messenger RNA for the synthesis of renin has been detected, and a tissue-bound converting enzyme is also present, as well as Ang II, its precursor Ang I, and the metabolite angiotensin III. 3 5 Such a local renin-angiotensin system may be responsible for a variety of physiol ...
Opioid-Induced Nausea
... • Schedule anti‐emetics. Start with a low‐cost drug such as a dopamine receptor antagonist (e.g., prochlorperazine); use 5HT3 antagonists for more refractory cases. Antihistamines or scopolamine may be helpful for patients who note increased nausea from motion. • Adjust the opioid dose. If good p ...
... • Schedule anti‐emetics. Start with a low‐cost drug such as a dopamine receptor antagonist (e.g., prochlorperazine); use 5HT3 antagonists for more refractory cases. Antihistamines or scopolamine may be helpful for patients who note increased nausea from motion. • Adjust the opioid dose. If good p ...
DRUG PROFILES Structural formula of Losartan
... Protein Binding: Losartan and its active metabolite are highly bound to plasma proteins, primarily albumin, with plasma free fractions of 1.3% and 0.2%, respectively. Plasma protein binding is constant over the concentration range achieved with recommended doses. Studies in rats indicate that Losar ...
... Protein Binding: Losartan and its active metabolite are highly bound to plasma proteins, primarily albumin, with plasma free fractions of 1.3% and 0.2%, respectively. Plasma protein binding is constant over the concentration range achieved with recommended doses. Studies in rats indicate that Losar ...
hypertension
... 2. ACE inhibitors Captopril, Enalapril, Lisinopril, Perindopril, Ramipril, Fosinopril, etc. 3. Angiotensin (AT1 receptor) blockers Losartan, Candesartan, Irbesartan, Valsartan, Telmisartan ...
... 2. ACE inhibitors Captopril, Enalapril, Lisinopril, Perindopril, Ramipril, Fosinopril, etc. 3. Angiotensin (AT1 receptor) blockers Losartan, Candesartan, Irbesartan, Valsartan, Telmisartan ...
Glucocorticoids
... Important Glucocorticoids CORTISOL [hydrocortisone] • Synthetized from 17-OH-pregnenolone • 95% is bound in the plasma by corticosteroid-binding globulin • As a drug: • Short action • Good oral availability • Cleared by the liver • Poor transdermal availability, but absorbed across inflamed skin • ...
... Important Glucocorticoids CORTISOL [hydrocortisone] • Synthetized from 17-OH-pregnenolone • 95% is bound in the plasma by corticosteroid-binding globulin • As a drug: • Short action • Good oral availability • Cleared by the liver • Poor transdermal availability, but absorbed across inflamed skin • ...
Document
... – Effect on a tissue: depends on sympathetic or parasy. system is dominant – No longer are used to treat chronic hypertension – Trimethaphan is occasionally used in cases of hypertensive emergency, when extremely high blood pressure must be lowered rapidly ...
... – Effect on a tissue: depends on sympathetic or parasy. system is dominant – No longer are used to treat chronic hypertension – Trimethaphan is occasionally used in cases of hypertensive emergency, when extremely high blood pressure must be lowered rapidly ...
CHAPTER 8 ANTIHYPERTENSIVE DRUGS Classification 1
... Contraindications include bilateral renal artery stenosis, pregnancy, known allergy, and hyperkalaemia. High serum creatinine (> 3 mg/dl) is an indication for careful monitoring of renal function, and potassium. Benefits can still be obtained in spite of renal insufficiency. A slight stable increase ...
... Contraindications include bilateral renal artery stenosis, pregnancy, known allergy, and hyperkalaemia. High serum creatinine (> 3 mg/dl) is an indication for careful monitoring of renal function, and potassium. Benefits can still be obtained in spite of renal insufficiency. A slight stable increase ...
View Abstract - Journal of Scientific and Innovative Research
... plasma volume depletion. 12 In mild to moderate hypertensive patients, the terminal half-life is 24 h, which is longer than all other ARBs on the market currently. 8 Mechanism of Action: As angiotensin II is a vasoconstrictor, which also stimulates the synthesis and release of aldosterone, blockage ...
... plasma volume depletion. 12 In mild to moderate hypertensive patients, the terminal half-life is 24 h, which is longer than all other ARBs on the market currently. 8 Mechanism of Action: As angiotensin II is a vasoconstrictor, which also stimulates the synthesis and release of aldosterone, blockage ...
5HT1F- and 5HT7-Receptor Agonists for the Treatment of Migraines
... parts of the trigeminovascular system only for 5-HT1 subtypes, the 5-HT1B and 5-HT1D in particular. The main action of sumatriptan, the first among several compounds classified into this triptan class of medications, was found to be on activation of these receptor subtypes (5-HT1B, 5-HT1D). Unnfortu ...
... parts of the trigeminovascular system only for 5-HT1 subtypes, the 5-HT1B and 5-HT1D in particular. The main action of sumatriptan, the first among several compounds classified into this triptan class of medications, was found to be on activation of these receptor subtypes (5-HT1B, 5-HT1D). Unnfortu ...