Inhibition of platelet aggregability by losartan in essential hypertension
... those required for binding to vascular AT1 receptors 8, 9, 13. Although the argument has been posed that chronic therapy with losartan (80 to 120 mg oral dose) may expose platelets to circulating drug concentrations amounting to 1 µmol/L 8, 13 this study now shows directly that losartan induced a st ...
... those required for binding to vascular AT1 receptors 8, 9, 13. Although the argument has been posed that chronic therapy with losartan (80 to 120 mg oral dose) may expose platelets to circulating drug concentrations amounting to 1 µmol/L 8, 13 this study now shows directly that losartan induced a st ...
Is there a difference between an angiotensin
... diuretics caused less strokes and heart failure than first-line RAS inhibitors. There was low-quality evidence on the effect on endstage renal failure, and a conclusion could not be drawn in this regard. There were limited data on serious side-effects in these trials, and again therefore, conclusion ...
... diuretics caused less strokes and heart failure than first-line RAS inhibitors. There was low-quality evidence on the effect on endstage renal failure, and a conclusion could not be drawn in this regard. There were limited data on serious side-effects in these trials, and again therefore, conclusion ...
Mechanisms of Therapeutic Actions and Adverse Side Effects
... Each atypical antipsychotic agent has a binding profile that differs from other antipsychotics. An antipsychotic’s binding profile is a summation of the receptors to which it binds, the strength of the binding to individual receptor types (binding affinity or Ki), and the action of the drug on that ...
... Each atypical antipsychotic agent has a binding profile that differs from other antipsychotics. An antipsychotic’s binding profile is a summation of the receptors to which it binds, the strength of the binding to individual receptor types (binding affinity or Ki), and the action of the drug on that ...
Towards a Molecular Description of the GABA
... Pentameric integral membrane protein containing an ion channel selective for chloride ions. ...
... Pentameric integral membrane protein containing an ion channel selective for chloride ions. ...
Proceedings of the British Pharmacological Society
... increases food intake in satiated or non-deprived animals by a central mechanism of action (1). In order to test the hypothesis that endogenous GABA, acting at central GABAB receptors, plays a physiological role in the control of feeding behaviour, we argued that blocking these receptors with a cent ...
... increases food intake in satiated or non-deprived animals by a central mechanism of action (1). In order to test the hypothesis that endogenous GABA, acting at central GABAB receptors, plays a physiological role in the control of feeding behaviour, we argued that blocking these receptors with a cent ...
Medicinal Chemistry N.19 Biological Activity and
... • A biological response is produced by the interaction with the biological receptor site. • This interaction would be expected to take place by using the same bonding forces as are involved when simple molecules interact. ...
... • A biological response is produced by the interaction with the biological receptor site. • This interaction would be expected to take place by using the same bonding forces as are involved when simple molecules interact. ...
Antihypertensive Drugs
... Specific angiotensin receptors have been discovered, grouped and abbreviated as – AT1 and AT2 They are present on the surface of the target cells Most of the physiological actions of angiotensin are mediated via AT1 receptor Transducer mechanisms of AT1 inhibitors: In different tissues show differen ...
... Specific angiotensin receptors have been discovered, grouped and abbreviated as – AT1 and AT2 They are present on the surface of the target cells Most of the physiological actions of angiotensin are mediated via AT1 receptor Transducer mechanisms of AT1 inhibitors: In different tissues show differen ...
