No Slide Title
... Phase III (2-6 years) - establishes efficacy and adverse effects from long-term use with several thousand patients New Drug Application (NDA) submitted to FDA (4-36 months) Phase IV - results after drug is on market ...
... Phase III (2-6 years) - establishes efficacy and adverse effects from long-term use with several thousand patients New Drug Application (NDA) submitted to FDA (4-36 months) Phase IV - results after drug is on market ...
Gastro17-GIPharm2
... Important prokinetic effects = increases gastric emptying and motility of GI tract Blocks both D2 and 5-HT3 receptors, 5-HT4 agonist o Serotonin blockade is more important than dopamine blocking activity Useful in diabetic neuropathy/gastroparesis, cancer chemo, postoperative N&V, GERD, migrai ...
... Important prokinetic effects = increases gastric emptying and motility of GI tract Blocks both D2 and 5-HT3 receptors, 5-HT4 agonist o Serotonin blockade is more important than dopamine blocking activity Useful in diabetic neuropathy/gastroparesis, cancer chemo, postoperative N&V, GERD, migrai ...
Dose-Response Concept
... duration but 30 days to 90 days can be used Usually oral administration of the chemical via food; also implant Used to further characterize the specific organs affected by test compound after repeated administration of the chemical ...
... duration but 30 days to 90 days can be used Usually oral administration of the chemical via food; also implant Used to further characterize the specific organs affected by test compound after repeated administration of the chemical ...
The Atypical Antipsychotics
... atypical agents are serotonin-dopamine 2 antagonists (SDAs) They are considered atypical in the way they affect dopamine and serotonin neurotransmission in the four key dopamine pathways in the brain. Mechanism of action Dopamine receptor blocking activity in the brain:. D1 and D5 receptors activate ...
... atypical agents are serotonin-dopamine 2 antagonists (SDAs) They are considered atypical in the way they affect dopamine and serotonin neurotransmission in the four key dopamine pathways in the brain. Mechanism of action Dopamine receptor blocking activity in the brain:. D1 and D5 receptors activate ...
12 Allergy Drugs
... b-agonists: activate adenylcyclase enzyme = increases c-AMP (cyclic adenosine monophosphate) c-AMP activates phosphorylation of HO-containing amino acids (tyrosine, serine and threonine) which causes the enzyme to change shape = release of Ca2+ ions from their storage sites = relaxation of muscles ...
... b-agonists: activate adenylcyclase enzyme = increases c-AMP (cyclic adenosine monophosphate) c-AMP activates phosphorylation of HO-containing amino acids (tyrosine, serine and threonine) which causes the enzyme to change shape = release of Ca2+ ions from their storage sites = relaxation of muscles ...
MIGRAINE
... b.v. may be due to release of 5HT from platelet or mast cells. Migraine aura occurs in this phase. PHASE (2): V.D. of intra & extracranial b.v. may be due to release of neurotransmitters as substance P ,or ...
... b.v. may be due to release of 5HT from platelet or mast cells. Migraine aura occurs in this phase. PHASE (2): V.D. of intra & extracranial b.v. may be due to release of neurotransmitters as substance P ,or ...
Medicinal chemistry
... relationship between chemical structure and pharmacological activity for a series of compounds. • Lead compound is a compound that has a desirable biological activity with therapeutic relevance, but typically has some shortcoming that is likely to be overcome through the development of analogs. ...
... relationship between chemical structure and pharmacological activity for a series of compounds. • Lead compound is a compound that has a desirable biological activity with therapeutic relevance, but typically has some shortcoming that is likely to be overcome through the development of analogs. ...
Automated Solutions for Cellular Screening and Characterization of
... antibodies and other competitive binding proteins, while the MultiFlo is able to rapidly dispense cells, media, and antibodies to LV384-well plates in a non-contact format ...
... antibodies and other competitive binding proteins, while the MultiFlo is able to rapidly dispense cells, media, and antibodies to LV384-well plates in a non-contact format ...
PNB-0718
... Presence of AT4 receptors on endothelial cells Importance of endothelial cells in regulating blood vessel growth (angiogenesis) Numerous pathologies with aberrant blood vessel growth (too much or too little) Cancer! ...
... Presence of AT4 receptors on endothelial cells Importance of endothelial cells in regulating blood vessel growth (angiogenesis) Numerous pathologies with aberrant blood vessel growth (too much or too little) Cancer! ...
Pharmacology Lecture McGill U Oct 11 2000
... – receptors NK1 and NK2 – ? transmitters or neuromodulators Calcitonin Gene-Related Peptide (CGRP) – localised in greater % of nociceptive afferents than SP – possibly two receptor sub-types – excitatory centrally, powerful vasodilator peripherally, – role unclear ...
... – receptors NK1 and NK2 – ? transmitters or neuromodulators Calcitonin Gene-Related Peptide (CGRP) – localised in greater % of nociceptive afferents than SP – possibly two receptor sub-types – excitatory centrally, powerful vasodilator peripherally, – role unclear ...
File
... • The nausea and vomiting produced by chemotherapeutic agents demands especially effective management. • Nearly 70% to 80% of patients who undergo chemotherapy experience nausea and/or vomiting. • Several factors influence the incidence and severity of chemotherapy-induced nausea and vomiting (CINV) ...
... • The nausea and vomiting produced by chemotherapeutic agents demands especially effective management. • Nearly 70% to 80% of patients who undergo chemotherapy experience nausea and/or vomiting. • Several factors influence the incidence and severity of chemotherapy-induced nausea and vomiting (CINV) ...
sedative-hypnotic
... these drugs are referred to as tranquilizers and sleeping pills or sometimes just as sedatives. Their effects range from calming down anxious people to promoting sleep. Both tranquilizers and sleeping pills can have either effect, depending on how much is taken. At high doses or when they are abused ...
... these drugs are referred to as tranquilizers and sleeping pills or sometimes just as sedatives. Their effects range from calming down anxious people to promoting sleep. Both tranquilizers and sleeping pills can have either effect, depending on how much is taken. At high doses or when they are abused ...
Current and Upcoming Approaches to Medically Supervised
... to involve multiple polymorphisms, including single nucleotide polymorphisms (SNPs) in different genes. ...
... to involve multiple polymorphisms, including single nucleotide polymorphisms (SNPs) in different genes. ...
File - Wk 1-2
... several days fro recovery) Receptors are taken into cell be endocytosis and also depends on receptor phosphorylation Common for hormone receptors Exhaustion of mediators Desensitisation can be associated with depletion of an intermediate substance (rarer) Increased metabolic degradation of the ...
... several days fro recovery) Receptors are taken into cell be endocytosis and also depends on receptor phosphorylation Common for hormone receptors Exhaustion of mediators Desensitisation can be associated with depletion of an intermediate substance (rarer) Increased metabolic degradation of the ...
Drug Dosage and Clinical Responses
... – Physiological – Two drugs produce opposite effects on the same system (epinephrine in the treatment of histamine-induced bronchospasm) ...
... – Physiological – Two drugs produce opposite effects on the same system (epinephrine in the treatment of histamine-induced bronchospasm) ...
Drugs Affecting Uterine Contraction
... spectrum of action (partial agonist effects at alpha-adrenoceptors, some at 5-HT receptors) 3. Uterine smooth muscle * Ergonovine : is more selective than other ergot alkaloids in affecting the uterus * the uterus at term is more sensitive than the earlier in pregnancy * very small doses : rhythm co ...
... spectrum of action (partial agonist effects at alpha-adrenoceptors, some at 5-HT receptors) 3. Uterine smooth muscle * Ergonovine : is more selective than other ergot alkaloids in affecting the uterus * the uterus at term is more sensitive than the earlier in pregnancy * very small doses : rhythm co ...
Pharmacodynamics
... Logarithmic concent-response curves for a single agonist acting on the same receptor subtype in tissues with different proportions of spare receptors (A, B, C, and D) muscle contraction in vitro. Note all tissues show same max response to drug (intrinsic activity). The agonist shows highest poten ...
... Logarithmic concent-response curves for a single agonist acting on the same receptor subtype in tissues with different proportions of spare receptors (A, B, C, and D) muscle contraction in vitro. Note all tissues show same max response to drug (intrinsic activity). The agonist shows highest poten ...
Important side effects to be considered when choosing antipsychotic
... Other effects: Blockade of -adrenergic receptors causes orthostatic hypotension and light-headedness. The neuroleptics also alter temperature-regulating mechanisms and can produce poikilothermia (body temperature varies with the environment). In the pituitary, neuroleptics block D2 receptors, lea ...
... Other effects: Blockade of -adrenergic receptors causes orthostatic hypotension and light-headedness. The neuroleptics also alter temperature-regulating mechanisms and can produce poikilothermia (body temperature varies with the environment). In the pituitary, neuroleptics block D2 receptors, lea ...
Document
... adrenaline (肾上腺素) and noradrenaline (去甲肾上腺素). Widely distributed, being responsible for control of the stimulation and relaxation of muscle, including the heart. Mediate the control of cardiac function by the sympathetic nervous system; the parasympathetic nervous system control is mediated by musca ...
... adrenaline (肾上腺素) and noradrenaline (去甲肾上腺素). Widely distributed, being responsible for control of the stimulation and relaxation of muscle, including the heart. Mediate the control of cardiac function by the sympathetic nervous system; the parasympathetic nervous system control is mediated by musca ...
Cardiovascular Agents
... Antagonists target the voltagedependent L-type calcium channels that release the calcium ions responsible for cardiac and smooth muscle contraction. Bind the calcium channel and prevent it from releasing calcium ions. ...
... Antagonists target the voltagedependent L-type calcium channels that release the calcium ions responsible for cardiac and smooth muscle contraction. Bind the calcium channel and prevent it from releasing calcium ions. ...
Virtual Screening in Drug Discovery: an Overview
... The goal of early stage drug discovery: to identify hits and leads compounds • Most drugs work by interacting with a protein/DNA at a specific target site. • Drug molecules need to (1) bind tightly to the target site (affinity) and exert the desired activity (potency) (2) have minimal off-target bi ...
... The goal of early stage drug discovery: to identify hits and leads compounds • Most drugs work by interacting with a protein/DNA at a specific target site. • Drug molecules need to (1) bind tightly to the target site (affinity) and exert the desired activity (potency) (2) have minimal off-target bi ...
Exploring the Possible Mode of Anxiolytic Action
... investigated to explore the anti-anxiolytic activity and, its mode of action through competitive GABA receptor bindings with different antagonists of known nature e.g., flumazenil, picrotoxin and bicuculine. The open field, staircase test and, mirror chamber tests of animal models of anxiety were em ...
... investigated to explore the anti-anxiolytic activity and, its mode of action through competitive GABA receptor bindings with different antagonists of known nature e.g., flumazenil, picrotoxin and bicuculine. The open field, staircase test and, mirror chamber tests of animal models of anxiety were em ...
