Chapter 4
... e.g. heroin, once taken regularly enough, individual will suffer withdrawal symptoms (opposite to those produced by a drug) when they stop taking it; caused by same mech as tolerance Tolerance is the body’s attempt to compensate for the effects of a drug ...
... e.g. heroin, once taken regularly enough, individual will suffer withdrawal symptoms (opposite to those produced by a drug) when they stop taking it; caused by same mech as tolerance Tolerance is the body’s attempt to compensate for the effects of a drug ...
Ligand Residence Time at G-protein–Coupled Receptors—Why We
... elimination is faster than its dissociation from the receptor complex (Dahl and Akerud, 2013). In this case the residence time directly depends on the dissociation rate of the drug from its complex with the receptor. The detection of dissociation rates initially looks straightforward, because most o ...
... elimination is faster than its dissociation from the receptor complex (Dahl and Akerud, 2013). In this case the residence time directly depends on the dissociation rate of the drug from its complex with the receptor. The detection of dissociation rates initially looks straightforward, because most o ...
Newer Antihypertensive Drugs
... Azilsartan Medoxomil at its maximal dose has superior efficacy to both Olmesartan and Valsartan at their maximal, approved doses without increasing adverse events. Azilsartan Medoxomil could provide higher rates of hypertension control within the ARB class. Hypertension 2011; 57: 413-4205 ...
... Azilsartan Medoxomil at its maximal dose has superior efficacy to both Olmesartan and Valsartan at their maximal, approved doses without increasing adverse events. Azilsartan Medoxomil could provide higher rates of hypertension control within the ARB class. Hypertension 2011; 57: 413-4205 ...
5-HT2a – receptor agonist
... (nausea, vomiting, dizziness, anxiety, headache, hallucinations and irrational behavior, myosis) • MDMA-like chemical structure + weak inhibitor MAO • extremely long time before peak (4-7 hours), effects last for 24-72 hours ...
... (nausea, vomiting, dizziness, anxiety, headache, hallucinations and irrational behavior, myosis) • MDMA-like chemical structure + weak inhibitor MAO • extremely long time before peak (4-7 hours), effects last for 24-72 hours ...
delta receptor
... • Opioid Antagonists are used to treat opioid overdose cases. • Most are derived from Thebaine (an alkaloid of Opium) • The have strong binding affinity for the mu receptors • They work by competitive inhibition at the binding site (It binds but does not change the receptor while at the same time bl ...
... • Opioid Antagonists are used to treat opioid overdose cases. • Most are derived from Thebaine (an alkaloid of Opium) • The have strong binding affinity for the mu receptors • They work by competitive inhibition at the binding site (It binds but does not change the receptor while at the same time bl ...
Lecture 14
... mood inappropriation, paranoia (persecution mania) and hallucinations (voices) and Negative symptoms: withdrawal from society, flattened emotional responses, defect in selective attention (can’t distinguish between important and insignificant) Affects up to 1% of population, high suicide rate (10%) ...
... mood inappropriation, paranoia (persecution mania) and hallucinations (voices) and Negative symptoms: withdrawal from society, flattened emotional responses, defect in selective attention (can’t distinguish between important and insignificant) Affects up to 1% of population, high suicide rate (10%) ...
Protein–Ligand Interactions as the Basis for Drug Action
... investigated protein ligand complexes shows that Ki has no direct relationship to the number of hydrogen bonds that exist between protein and ligand • Data based on X-‐ray structures and indicates that H- ...
... investigated protein ligand complexes shows that Ki has no direct relationship to the number of hydrogen bonds that exist between protein and ligand • Data based on X-‐ray structures and indicates that H- ...
PPT
... & Slow heart rate which contribute to clinical benefits. The long-term use of timolol, propranolol, or metoprolol in patients who have had a myocardial ...
... & Slow heart rate which contribute to clinical benefits. The long-term use of timolol, propranolol, or metoprolol in patients who have had a myocardial ...
Pritor® 40(80) mg and Co-Pritor® 40(80/12.5 mg)
... Published data on the use of telmisartan in humans confirms its sustained 24-hour antihypertensive effects and clinical efficacy. The BP-lowering efficacy over the entire 24-hour dose administration interval is consistent with the pharmacokinetic profile of telmisartan, which has the longest elimina ...
... Published data on the use of telmisartan in humans confirms its sustained 24-hour antihypertensive effects and clinical efficacy. The BP-lowering efficacy over the entire 24-hour dose administration interval is consistent with the pharmacokinetic profile of telmisartan, which has the longest elimina ...
Antiemetic Guidelines for Chemotherapy and Radiation Therapy
... Aprepitant is an NK1 receptor antagonist, the first drug of a new class of oral anti-emetics for chemo-induced emesis and nausea. Evidence: Three randomized controlled trials including over 1,800 patients have demonstrated significant improvements in complete response of 20% in highly emetogenic xii ...
... Aprepitant is an NK1 receptor antagonist, the first drug of a new class of oral anti-emetics for chemo-induced emesis and nausea. Evidence: Three randomized controlled trials including over 1,800 patients have demonstrated significant improvements in complete response of 20% in highly emetogenic xii ...
Pharmacology Tutoring for Sedative Hypnotics and Antiemetics
... Which of the following serotonin antagonists has affinity for more than one type of serotonin receptor? ...
... Which of the following serotonin antagonists has affinity for more than one type of serotonin receptor? ...
Chart compiled by Zak Fallows
... smelling colors. Crazy in the long term, or 5-MeO-DiPT, DET, AMT, 4-HO-DiPT dealing with perception. cause "flashbacks" ideas and beliefs. (HPPD). Some cause Same as above, plus nausea, increased body Same as above, plus Lysergic acid diethylamine (LSD), LSA other effects, depends temperature, tremor ...
... smelling colors. Crazy in the long term, or 5-MeO-DiPT, DET, AMT, 4-HO-DiPT dealing with perception. cause "flashbacks" ideas and beliefs. (HPPD). Some cause Same as above, plus nausea, increased body Same as above, plus Lysergic acid diethylamine (LSD), LSA other effects, depends temperature, tremor ...
Neuronal function
... A) Autoreceptors and pre-synaptic inhibition 6. Neurotransmitters A) Receptors B) Distribution in brain C) Drug actions Read Kalat chapter 2 and 3 _________________________________________________________________________ Important neuron parts: Dendrites Soma or Cell Body (contains axon hillock) Axo ...
... A) Autoreceptors and pre-synaptic inhibition 6. Neurotransmitters A) Receptors B) Distribution in brain C) Drug actions Read Kalat chapter 2 and 3 _________________________________________________________________________ Important neuron parts: Dendrites Soma or Cell Body (contains axon hillock) Axo ...
Muscarinic AChR agonist
... Cholinergic receptors Two classes for acetylcholine Nicotinic and muscarinic Nicotinic ...
... Cholinergic receptors Two classes for acetylcholine Nicotinic and muscarinic Nicotinic ...
DRUGS AFFECTING THE RESPIRATORY SYSTEM
... Involves combined use of antihistamines, nasal decongestants, antitussives, and expectorants Treatment is “empiric therapy,” treating the most likely cause Antivirals and antibiotics may be used, but a definite viral or bacterial cause may not be easily identified ...
... Involves combined use of antihistamines, nasal decongestants, antitussives, and expectorants Treatment is “empiric therapy,” treating the most likely cause Antivirals and antibiotics may be used, but a definite viral or bacterial cause may not be easily identified ...
What is mental life
... c. Xenon, nitrous oxide, ketamine i. Minimal effect on GABA-A receptor but marked blockade of NMDA action 4) Sensitivity to volatile agents vary a. Genetic predisposition, ethnicity 5) Surgery procedure and general anesthesia a. Induction maintenance emergence ...
... c. Xenon, nitrous oxide, ketamine i. Minimal effect on GABA-A receptor but marked blockade of NMDA action 4) Sensitivity to volatile agents vary a. Genetic predisposition, ethnicity 5) Surgery procedure and general anesthesia a. Induction maintenance emergence ...
PharmII Block I Handouts
... All of these have reduce the production of acid by blocking the H2 receptors on the parietal cell. They are used to prevent NSAID-induced ulcers and in the treatment and maintenance of peptic ...
... All of these have reduce the production of acid by blocking the H2 receptors on the parietal cell. They are used to prevent NSAID-induced ulcers and in the treatment and maintenance of peptic ...
Opioid Pharmacology
... • Opiate refers to any agent derived from opium • Opioid refers to all substances (exogenous or endogenous) with morphine -like properties • The generic term for the class of agents is “opioid” ...
... • Opiate refers to any agent derived from opium • Opioid refers to all substances (exogenous or endogenous) with morphine -like properties • The generic term for the class of agents is “opioid” ...
PSYC 342: Psychopharmacology
... • A syndrome present in many illnesses – remove known cause or treat underlying illness – treat symptomatically with antipsychotic medications ...
... • A syndrome present in many illnesses – remove known cause or treat underlying illness – treat symptomatically with antipsychotic medications ...
The future of pharmacological treatment. Anne Lingford-Hughes Professor of Addiction Biology, Imperial College.
... Drugs of abuse increase dopamine concentration in the nucleus accumbens of the mesolimbic system Dopamine system is modulated by other ...
... Drugs of abuse increase dopamine concentration in the nucleus accumbens of the mesolimbic system Dopamine system is modulated by other ...
I. The direct-acting drugs
... chemical structures and mechanism of action To understand major pharmacological effects and therapeutic applications To understand major adverse reactions ...
... chemical structures and mechanism of action To understand major pharmacological effects and therapeutic applications To understand major adverse reactions ...
DOPAMINE ANTAGONISTS: PHENOTHIAZINE/THIOXANTHENE SAR
... receptors. They also exhibit varying degrees of selectivity among the cortical dopamine tracts; nigrostriatal (movement disorders), mesolimbic (relief of hallucinations and delusions), mesocortical (relief of psychosis, worsening of negative symptoms) or tuberoinfundibular (prolactin release). They ...
... receptors. They also exhibit varying degrees of selectivity among the cortical dopamine tracts; nigrostriatal (movement disorders), mesolimbic (relief of hallucinations and delusions), mesocortical (relief of psychosis, worsening of negative symptoms) or tuberoinfundibular (prolactin release). They ...
File
... Drugs interact with receptors by means of chemical forces or bonds. These are of three major types: 1. Covalent: It is very strong and in many cases not reversible under biologic conditions. Thus, the duration of drug action is frequently, but not necessarily, prolonged (irreversible) 2. Electrosta ...
... Drugs interact with receptors by means of chemical forces or bonds. These are of three major types: 1. Covalent: It is very strong and in many cases not reversible under biologic conditions. Thus, the duration of drug action is frequently, but not necessarily, prolonged (irreversible) 2. Electrosta ...