Tricyclic Antidepressants
... TCAs have several important cellular effects, including: Inhibition of presynaptic neurotransmitter reuptake (norepinephrine and serotonin) Blockade of cardiac fast sodium channels Antagonism of central and peripheral muscarinic acetylcholine receptors Antagonism of peripheral alpha-1 adrene ...
... TCAs have several important cellular effects, including: Inhibition of presynaptic neurotransmitter reuptake (norepinephrine and serotonin) Blockade of cardiac fast sodium channels Antagonism of central and peripheral muscarinic acetylcholine receptors Antagonism of peripheral alpha-1 adrene ...
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... gastrointestinal side effects. Alcohol: increased risk of gastrointestinal ulcers and bleeding. Other analgesics and anti-inflammatory medicines (nonsteroidal anti-inflammatory drugs) and other antirheumatic medicines in general: increased risk for gastrointestinal ulcers and bleeding. Antidiabetics ...
... gastrointestinal side effects. Alcohol: increased risk of gastrointestinal ulcers and bleeding. Other analgesics and anti-inflammatory medicines (nonsteroidal anti-inflammatory drugs) and other antirheumatic medicines in general: increased risk for gastrointestinal ulcers and bleeding. Antidiabetics ...
Review: misoprostol, double dose H2 receptor antagonists, and
... Traditional NSAIDs cause endoscopic ulcers in up to 40% of patients who have long term exposure, but only 15% of the ulcers ever clinically manifest, with an annual incidence of serious complications of approximately 1.5%.1 Older patients ( > 65 y) and those with past peptic ulcer or comorbid condit ...
... Traditional NSAIDs cause endoscopic ulcers in up to 40% of patients who have long term exposure, but only 15% of the ulcers ever clinically manifest, with an annual incidence of serious complications of approximately 1.5%.1 Older patients ( > 65 y) and those with past peptic ulcer or comorbid condit ...
Medicinal chemistry
... relationship between chemical structure and pharmacological activity for a series of compounds. • Lead compound is a compound that has a desirable biological activity with therapeutic relevance, but typically has some shortcoming that is likely to be overcome through the development of analogs. ...
... relationship between chemical structure and pharmacological activity for a series of compounds. • Lead compound is a compound that has a desirable biological activity with therapeutic relevance, but typically has some shortcoming that is likely to be overcome through the development of analogs. ...
Enzymes - ISpatula
... so ... we have 3 issues when talking about drug absorption that are dissolution, permeability and stability, and we need to overcome these problem in order to reach the site of action in sufficient concentration and give a response. Regarding affecting permeation, we can do: 1) prodrug, but it is ...
... so ... we have 3 issues when talking about drug absorption that are dissolution, permeability and stability, and we need to overcome these problem in order to reach the site of action in sufficient concentration and give a response. Regarding affecting permeation, we can do: 1) prodrug, but it is ...
LOs Parmicokinetics 5 - 8 - PBL-J-2015
... Body Burden = total amount of compound in body (Q) = Cp x Vd (from the above equation) Eg: Digoxin has a volume of distribution of 7L/kg. What is the peak plasma concentration if 500µg is administered to a 12kg child. ...
... Body Burden = total amount of compound in body (Q) = Cp x Vd (from the above equation) Eg: Digoxin has a volume of distribution of 7L/kg. What is the peak plasma concentration if 500µg is administered to a 12kg child. ...
Omeprazole - School Nurse
... Do not crush, chew, or break an enteric-coated omeprazole tablet. Swallow the pill whole. The enteric-coated pill has a special coating to protect your stomach. Breaking the pill could damage this coating. You may open the omeprazole delayed-release capsule and sprinkle the medicine into a spoonful ...
... Do not crush, chew, or break an enteric-coated omeprazole tablet. Swallow the pill whole. The enteric-coated pill has a special coating to protect your stomach. Breaking the pill could damage this coating. You may open the omeprazole delayed-release capsule and sprinkle the medicine into a spoonful ...
... enzyme catalyses the Sn-2 hydrolysis of phospholipids liberating free fatty acids predominantly arachidonic acid, and lysophospholipids. These products can have biological actions (or) be further metabolized to form a variety of proinflammatory lipid mediators including prostaglandins, leukotrienes ...
Tranquilizers and Sedative-Hypnotics
... and the effects last up to six hours. These drugs are primarily used for insomnia and preoperative sedation. Veterinarians use pentobarbital for anesthesia and euthanasia. • Long-acting barbiturates include phenobarbital (Luminal®) and mephobarbital (Mebaral®), Effects of these drugs are realized in ...
... and the effects last up to six hours. These drugs are primarily used for insomnia and preoperative sedation. Veterinarians use pentobarbital for anesthesia and euthanasia. • Long-acting barbiturates include phenobarbital (Luminal®) and mephobarbital (Mebaral®), Effects of these drugs are realized in ...
studies on formulation and evaluation of floating tablet
... 3. H2 receptor antagonists: They are commonly known as specific drugs. They directly suppress the secretion of gastric acid. common example is cimetidine , ranitidine.2 Nizatidine is used for the treatment of acid-reflux disorders, peptic ulcer disease, active benign gastric ulcer and active duoden ...
... 3. H2 receptor antagonists: They are commonly known as specific drugs. They directly suppress the secretion of gastric acid. common example is cimetidine , ranitidine.2 Nizatidine is used for the treatment of acid-reflux disorders, peptic ulcer disease, active benign gastric ulcer and active duoden ...
Part IB Summary of Product Characteristics
... Rabeprazole sodium, as is the case with other members of the proton pump inhibitor (PPI) class of compounds, is metabolised through the cytochrome P450 (CYP450) hepatic drug metabolising system. In vitro studies with human liver microsomes indicated that rabeprazole sodium is metabolised by isoenzym ...
... Rabeprazole sodium, as is the case with other members of the proton pump inhibitor (PPI) class of compounds, is metabolised through the cytochrome P450 (CYP450) hepatic drug metabolising system. In vitro studies with human liver microsomes indicated that rabeprazole sodium is metabolised by isoenzym ...
Grade 2008-2010 final exam-A
... 16. All of the following statements about cimetidine are true except A. An H2-receptor blocker B. used in peptic ulcer C. reduced the secretion of gastric acid D. little adverse reactions E. recurrence is rare after treatment is stopped 17. The patients with bronchial asthma can not be given A. adre ...
... 16. All of the following statements about cimetidine are true except A. An H2-receptor blocker B. used in peptic ulcer C. reduced the secretion of gastric acid D. little adverse reactions E. recurrence is rare after treatment is stopped 17. The patients with bronchial asthma can not be given A. adre ...
Module 4
... Pernicious anemia is caused by loss of gastric parietal cells, and subsequent inability to absorb vitamin B12. Megaloblastic anemia is an anemia (of macrocytic classification) that results from inhibition of DNA synthesis in red blood cell production. ...
... Pernicious anemia is caused by loss of gastric parietal cells, and subsequent inability to absorb vitamin B12. Megaloblastic anemia is an anemia (of macrocytic classification) that results from inhibition of DNA synthesis in red blood cell production. ...
02-Lecture_2 doc2008-10-31 07:3483 KB
... Drugs exist in 2 forms :free and bound forms in equilibrium. Drug reversible unbound(free)+bound. ...
... Drugs exist in 2 forms :free and bound forms in equilibrium. Drug reversible unbound(free)+bound. ...
Xamic - Renata Limited
... plasminogen activation of both exogenous activators like streptokinase and endogenous ones like urokinase and the plasminogen tissue activator. This fact is particularly important for the clinical use of Xamic ®, because it ensures an antihemorrhagic activity with an antifibrinolytic mechanism under ...
... plasminogen activation of both exogenous activators like streptokinase and endogenous ones like urokinase and the plasminogen tissue activator. This fact is particularly important for the clinical use of Xamic ®, because it ensures an antihemorrhagic activity with an antifibrinolytic mechanism under ...
A novel mechanism for oral controlled release of drugs by
... • In order to facilitate swallowing, it is highly desirable to design dosage forms with an initially small size that — once in the stomach — significantly increase in size. • The expanded state should be achieved rapidly in order to prevent premature emptying through the pylorus. • Conversely, the s ...
... • In order to facilitate swallowing, it is highly desirable to design dosage forms with an initially small size that — once in the stomach — significantly increase in size. • The expanded state should be achieved rapidly in order to prevent premature emptying through the pylorus. • Conversely, the s ...
GI Drugs
... Cimetidine blocks androgen receptors at high doses o CNS: Cross the BBB and cause confusion, dizziness, and slurred speech Drug interactions: inhibits many CYP450 alters metabolism of many drugs (e.g. warfarin, theophylline) Proton pump inhibitors (PPI) – Omeprazole (-prazole) Mechanism: irrev ...
... Cimetidine blocks androgen receptors at high doses o CNS: Cross the BBB and cause confusion, dizziness, and slurred speech Drug interactions: inhibits many CYP450 alters metabolism of many drugs (e.g. warfarin, theophylline) Proton pump inhibitors (PPI) – Omeprazole (-prazole) Mechanism: irrev ...
PRESCRIPTION DRUG STRATEGIES FOR STATES
... treated for (name the type of patients by symptoms, disease, etc.)? ...
... treated for (name the type of patients by symptoms, disease, etc.)? ...
Autacoid Drugs Major autacoids
... for the relief of bronchospasm in conditions such as asthma and chronic obstructive pulmonary disease. Salbutamol was the first selective β2-receptor agonist to be marketed — in 1968. The drug was an instant success, and has been used for the treatment of asthma ever since. Salbutamol sulfate is usu ...
... for the relief of bronchospasm in conditions such as asthma and chronic obstructive pulmonary disease. Salbutamol was the first selective β2-receptor agonist to be marketed — in 1968. The drug was an instant success, and has been used for the treatment of asthma ever since. Salbutamol sulfate is usu ...
Slide 1
... CYP1A2: biotransforms about 15% of medications CYP2D6: 2-6% of total enzymes but metabolizes up to 25% of medications CYP2E1: Significant in activation and inactivation of toxins, ethanol induction can lead to hepatotoxicity of paracetamol ...
... CYP1A2: biotransforms about 15% of medications CYP2D6: 2-6% of total enzymes but metabolizes up to 25% of medications CYP2E1: Significant in activation and inactivation of toxins, ethanol induction can lead to hepatotoxicity of paracetamol ...
q-dips: computer-based prediction of known and potential drug
... for clinicians. To help improve their management, we have developed an «expert» computer application: Q-DIPS (Quantitative Drug Interactions Prediction System). Q-DIPS gives extensive information, in dynamic tables, on which specific isozymes metabolize a given drug, or may be inhibited or induced b ...
... for clinicians. To help improve their management, we have developed an «expert» computer application: Q-DIPS (Quantitative Drug Interactions Prediction System). Q-DIPS gives extensive information, in dynamic tables, on which specific isozymes metabolize a given drug, or may be inhibited or induced b ...
Route of drugs administration
... -e.g:-asprin and phenobarbitone.(lipid soluble). 2)active transport:-substance (drugs) moves form low concentration to an area of high concentration. -need energy for hydrolysis of ATPand specific carrier. -e.g.:- Electrolytes(Na,K,Cl).vitamin ,amino acid. 3)endocytosis &exocytosis:-endocytosis by e ...
... -e.g:-asprin and phenobarbitone.(lipid soluble). 2)active transport:-substance (drugs) moves form low concentration to an area of high concentration. -need energy for hydrolysis of ATPand specific carrier. -e.g.:- Electrolytes(Na,K,Cl).vitamin ,amino acid. 3)endocytosis &exocytosis:-endocytosis by e ...
PATIENT`S NAME: MEDICATION: famotidine (Brand names include
... reactions. Notify your prescriber if any of these symptoms become bothersome. INTERACTIONS Although famotidine may not interact with others drugs, you should avoid alcohol and caffeine when taking it because they may increase gastric irritation. Don’t use herbal remedies without consulting your pres ...
... reactions. Notify your prescriber if any of these symptoms become bothersome. INTERACTIONS Although famotidine may not interact with others drugs, you should avoid alcohol and caffeine when taking it because they may increase gastric irritation. Don’t use herbal remedies without consulting your pres ...
Discovery and development of proton pump inhibitors
Proton pump inhibitors (PPIs) block the gastric hydrogen potassium ATPase (H+,K+-ATPase) and inhibit gastric acid secretion. These drugs have emerged as the treatment of choice for acid-related diseases, including gastroesophageal reflux disease (GERD) and peptic ulcer disease.PPIs also can bind to other types of proton pumps such as those that occur in cancer cells and are finding applications in the reduction of cancer cell acid efflux and reduction of chemotherapy drug resistance.