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No Slide Title
No Slide Title

... • May be caused by a physical or psychic stress factor • May be a symptom of almost any somatic disease or mental disorder • Is not necesserily caused by the reason which the person suffering from fatigue assumes ...
BRCA1 and BRCA2 mutation predictions using the BOADICEA and
BRCA1 and BRCA2 mutation predictions using the BOADICEA and

... genes [16,30]. The recently published BOADICEA (Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm) model was developed using a combination of population-based families and families with multiple affected individuals, mainly from the UK. It takes into account the simul ...
Frailty – Elders At Risk - College of Nursing and Health Innovation
Frailty – Elders At Risk - College of Nursing and Health Innovation

... Frailty is a common geriatric syndrome associated with increased vulnerability and decreased ability to maintain homeostasis. Recent consensus by frailty experts Prof’s. Fried and Rockwood define frailty as: ‘A medical syndrome with multiple causes and contributors that is characterized by diminishe ...
Shaken Baby Syndrome On Trial: A Statistical Analysis of Arguments
Shaken Baby Syndrome On Trial: A Statistical Analysis of Arguments

... the problem is not well structured. Statisticians and other researchers have been unable to analyze this problem in depth because it has been presented in such a way as to prevent serious theoretical or empirical analysis. In this study, I bring to bear a methodology of Causes of Effects and Effects ...
Species Selection in Comparative Studies of Aging and Antiaging
Species Selection in Comparative Studies of Aging and Antiaging

... 2002). As we move further away from humans and great apes, species tend to be smaller, less intelligent, and shorter-lived. This is apparent among Old World monkeys (family: Cercopithecidae), which are generally shorter-lived than apes. Two species of Old World ...
Aging, Theories of
Aging, Theories of

... Generations have little to do with chronological time, but rather designate position in a web of relationship; hence kinship systems are emphasized. Although age–class systems have explanatory power in primitive societies, they are not helpful as life course models in complex societies because of th ...
A Genome-Wide Association Study Identifies the Skin Color
A Genome-Wide Association Study Identifies the Skin Color

... Longevity Study n = 599). Although the four genes have previously been associated with skin color variation and skin cancer risk, all association signals remained highly significant (Po2 × 10 − 8) when conditioning the association analyses on skin color. We conclude that genetic variations in IRF4, M ...
HOW CAN BUSINESS BETTER SERVE OLDER CONSUMERS
HOW CAN BUSINESS BETTER SERVE OLDER CONSUMERS

New elements in modern biological theories of aging
New elements in modern biological theories of aging

... the most visible changes come first to their minds. One can notice more grey hair, or the skin does not seem as smooth as it used to be. These are just external signs of a series of processes going on within our cells and bodily systems that together constitute normal aging. Aging (also called senes ...
Required Courses
Required Courses

... individual. Through journaling and course discussions, the student is able to reflect upon the implications of his/her experience, develop enhanced communication skills with an elderly individual, and analyze the collaboration and communications among health care professionals and their clients. GER ...
Aging, Evolvability, and the Individual Benefit Requirement
Aging, Evolvability, and the Individual Benefit Requirement

... development and retention of maintenance and repair functions. However, some individuals in a non-aging population could be expected to live very long lives and produce very many descendents. (Note that this is an individual benefit. All those descendents would carry the genes of their individual pa ...
Psychological Perspectives on Aging
Psychological Perspectives on Aging

... theycall.selecrive optimization with conipensation. That model posits two major processes through Which elders can.main~ ~ tain high levels of functioning in critical life o ~ domain (See also Freund and Baltes, 1998). The first process, selection, suggests that, 'Ii across the life span, we cannot ...
Rates and Fitness Consequences of New Mutations in
Rates and Fitness Consequences of New Mutations in

... sequenced 294 Mb of putatively nonfunctional DNA as a control in a study of new mutations producing human genetic disease and found four new mutations, giving an estimate for m of 1.4 · 1028. The 1000 Genomes Project Consortium (2010) employed Illumina technology to sequence one offspring and two pa ...
Neurobiology of autism
Neurobiology of autism

... Acquired brain lesions/ medical co-morbidity  Tuberous sclerosis – 3-9% of all autism cases, more common in those with epilepsy – chromosome 16p involved in one variant (autism susceptibility genetic area? ADHD susceptibility genetic area) – dopamine genes on chromosome 9 affected in other TS vari ...
Mitochondrial 12S rRNA gene mutations affect RNA secondary
Mitochondrial 12S rRNA gene mutations affect RNA secondary

... with maternal transmission and in four of the sporadic cases, resulting in a total of 69 unrelated samples with the mtDNA A1555G mutation, indicating that 15% of our cohort of Spanish deaf patients is a carrier of the A1555G mutation. The 69 families or sporadic cases positive for the A1555G mutatio ...
Attitudes toward aging
Attitudes toward aging

... • Physical care, verbal and nonverbal behaviors exhibited toward them are colored by the beliefs held about them. • Ageism can lower or destroy the self-esteem of elders. • Limit the degree to which elder’s problems are worked up and managed by health professionals. • The elders become dependent and ...
Development of CassiaExtract as an Ingredient to
Development of CassiaExtract as an Ingredient to

... of a double-layer structure incorporating vascular endothelial cells surrounded by pericytes. When the structure is normal, the required amounts of nutrients are delivered to the skin as if they are seeping from a fine mesh. It has been previously recognized that in such cases where skin irritation ...
CytoFactors - What is anti
CytoFactors - What is anti

... build-up of molecular changes eventually affects physiological processes leading to the point where it may even compromise the general homeostasis of the body. As a consequence, we tend to become more vulnerable to environmental stress and age-related diseases as we grow old. Aging is also associate ...
Example - UBC Pathology
Example - UBC Pathology

... that exposure to antiretroviral drugs, especially at conception or very early in embryonic development may be associated with significant mtDNA damage (mtDNA mutations/deletions). The mitochondrial polymerase repair mechanism is relatively poor and mtDNA mutations, including those nucleoside-induced ...
mitochondria and aging - American Federation for Aging Research
mitochondria and aging - American Federation for Aging Research

... The injury caused by free ­radicals initiates a self-perpetuating cycle in which oxidative damage ­impairs mitochondrial function, which results in the ­generation of even greater amounts of oxygen-free radicals. Over time, the ...
mitochondria and aging - American Federation for Aging Research
mitochondria and aging - American Federation for Aging Research

... The injury caused by free ­radicals initiates a self-perpetuating cycle in which oxidative damage ­impairs mitochondrial function, which results in the ­generation of even greater amounts of oxygen-free radicals. Over time, the ...
Healthy Aging
Healthy Aging

... older and one half is younger. When median age increases pop is considered aging. Stats Can-2000-36.8 ...
Healthy Aging Communities Dimensions
Healthy Aging Communities Dimensions

... across the life span and recognize the multidimensional complexities of supporting older adults. These communities recognize that two older adult populations exist—the healthy, functioning majority and the frail minority— and plan accordingly. The probability of some type of disease or chronic condi ...
Fried et al, 2001 - EMGO Institute for Health and Care Research
Fried et al, 2001 - EMGO Institute for Health and Care Research

... – To ‘interventionist’ concept (90’s) • ‘narrow’ biomedical concept (Fried) • ‘broad’ epidemiological concept (Deeg, SCP, TFI) ...
The Epigenetics Behind Human Aging
The Epigenetics Behind Human Aging

... highly associated with epigenetics. Environmental factors, nourishment, and life experiences, all affect aging because DNA methylation is regulated by these factors [2]. This is a massive leap regarding the process of aging and shows that human longevity is not directly associated with genomics alon ...
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Progeroid syndromes

Progeroid syndromes (PS) are a group of rare genetic disorders that mimic physiological aging, making affected individuals appear to be older than they are. The term progeroid syndrome does not necessarily imply progeria (Hutchinson-Gilford progeria syndrome), which is a specific type of progeroid syndrome.Progeroid means ""resembling premature aging"", a definition that can apply to a broad range of diseases. Familial Alzheimer's disease and familial Parkinson's disease are two well-known accelerated-aging diseases that are more frequent in older individuals. They affect only one tissue and can be classified as unimodal progeroid syndromes. Segmental progeria, which is more frequently associated with the term progeroid syndrome, tends to affect multiple or all tissues while causing affected individuals to exhibit only some of the features associated with aging.All disorders within this group are thought to be monogenic, meaning they arise from mutations of a single gene. Most known PS are due to genetic mutations that lead to either defects in the DNA repair mechanism or defects in lamin A/C.Examples of PS include Werner syndrome (WS), Bloom syndrome (BS), Rothmund–Thomson syndrome (RTS), Cockayne syndrome (CS), xeroderma pigmentosum (XP), trichothiodystrophy (TTD), combined xeroderma pigmentosum-Cockayne syndrome (XP-CS), restrictive dermopathy (RD), and Hutchinson-Gilford progeria syndrome (HGPS). Individuals with these disorders tend to have a reduced lifespan. Progeroid syndromes have been widely studied in the fields of aging, regeneration, stem cells, and cancer. The most widely studied of the progeroid syndromes are Werner syndrome and Hutchinson-Gilford progeria, as they are seen to most resemble natural aging.
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