Renal Gluconeogenesis
... net hepatic glycogenolysis occurred at a rate of 5.5 µmol kg1 min1 and accounted for 45 ± 6% of the overall release of glucose into the circulation, which was measured isotopically. As indicated earlier, only the liver contains appreciable glycogen and glucose-6-phosphatase, making it the onl ...
... net hepatic glycogenolysis occurred at a rate of 5.5 µmol kg1 min1 and accounted for 45 ± 6% of the overall release of glucose into the circulation, which was measured isotopically. As indicated earlier, only the liver contains appreciable glycogen and glucose-6-phosphatase, making it the onl ...
Downloaded - Journal of Clinical Investigation
... fate for the glucose that is taken up by the liver (1) and defects in hepatic glycogen synthesis contribute to postprandial hyperglycemia of patients with poorly controlled insulin-dependent diabetes mellitus (IDDM)1 (2). Both insulin deficiency and relative hyperglucagonemia may lead to these abnor ...
... fate for the glucose that is taken up by the liver (1) and defects in hepatic glycogen synthesis contribute to postprandial hyperglycemia of patients with poorly controlled insulin-dependent diabetes mellitus (IDDM)1 (2). Both insulin deficiency and relative hyperglucagonemia may lead to these abnor ...
Hyperglycemia and Acute Coronary SyndromeA Scientific Statement
... without diabetes mellitus. Despite the findings from prior studies, many gaps in knowledge currently exist in our understanding of the association between elevated glucose levels and adverse outcomes in patients with ACS. First, there is currently no consensus about the precise glucose value (or ran ...
... without diabetes mellitus. Despite the findings from prior studies, many gaps in knowledge currently exist in our understanding of the association between elevated glucose levels and adverse outcomes in patients with ACS. First, there is currently no consensus about the precise glucose value (or ran ...
Hyperglycemia and Acute Coronary Syndrome A Scientific
... (AMI) with admission glucose !110 mg/dL was 3.9 compared with nondiabetic AMI patients who were normoglycemic. Among AMI patients with diabetes, those with admission glucose !180 mg/dL had a 70% relative increase in the risk of in-hospital death compared with diabetic patients with normal admission ...
... (AMI) with admission glucose !110 mg/dL was 3.9 compared with nondiabetic AMI patients who were normoglycemic. Among AMI patients with diabetes, those with admission glucose !180 mg/dL had a 70% relative increase in the risk of in-hospital death compared with diabetic patients with normal admission ...
Upregulated insulin secretion in insulin-resistant
... We previously demonstrated that the incretin effect and the β-cell responsiveness to glucagon-like peptide-1 (GLP-1) are increased in insulin resistant mice. Now we examined whether this could, first, be explained by increased islet GLP-1 receptor (GLP-1R) expression and, second, be leveraged by GPR ...
... We previously demonstrated that the incretin effect and the β-cell responsiveness to glucagon-like peptide-1 (GLP-1) are increased in insulin resistant mice. Now we examined whether this could, first, be explained by increased islet GLP-1 receptor (GLP-1R) expression and, second, be leveraged by GPR ...
Chapter033
... Osmolarity in Diabetes Mellitus • When blood glucose is high, increased blood osmolarity can cause cells to shrink • Nerve cells produce intracellular osmoles to keep their osmolarity balanced with the blood • When the client brings blood glucose back to normal, the nerve cells are hyperosmolar to ...
... Osmolarity in Diabetes Mellitus • When blood glucose is high, increased blood osmolarity can cause cells to shrink • Nerve cells produce intracellular osmoles to keep their osmolarity balanced with the blood • When the client brings blood glucose back to normal, the nerve cells are hyperosmolar to ...
Diabetes Management and Emergency Care Plan
... parents/guardians will be notified immediately. If no, check the appropriate box: ☐My child will enter blood glucose and carbohydrate numbers and will require staff to monitor entries. ☐Staff are required to enter blood glucose and/or carbohydrate numbers in the pump. Scheduled bolus times during sc ...
... parents/guardians will be notified immediately. If no, check the appropriate box: ☐My child will enter blood glucose and carbohydrate numbers and will require staff to monitor entries. ☐Staff are required to enter blood glucose and/or carbohydrate numbers in the pump. Scheduled bolus times during sc ...
Glucose Metabolism Rather Than Insulin Is a Main Determinant of
... During the clamps, serum leptin concentrations increased from 0 –360 min by 20.5 ⫾ 4.1% in the low-insulin-hypo, 33.6 ⫾ 7.6% in the high-insulin-hypo, 39.6 ⫾ 6.0% in the low-insulin-eu, and 60.4 ⫾ 7.6% in the high-insulin-eu condition. Thus, the changes in serum leptin were distinctly greater in hig ...
... During the clamps, serum leptin concentrations increased from 0 –360 min by 20.5 ⫾ 4.1% in the low-insulin-hypo, 33.6 ⫾ 7.6% in the high-insulin-hypo, 39.6 ⫾ 6.0% in the low-insulin-eu, and 60.4 ⫾ 7.6% in the high-insulin-eu condition. Thus, the changes in serum leptin were distinctly greater in hig ...
HYPOGLYCEMIA MANAGEMENT
... At the conclusion of this presentation, the learner will be able to: list the contraindications, adverse effects and drug interactions (if any) for D50W and Glucagon perform the medical math to administer D50W or Glucagon in the classroom setting, demonstrate how a D50W pre-load is assembled a ...
... At the conclusion of this presentation, the learner will be able to: list the contraindications, adverse effects and drug interactions (if any) for D50W and Glucagon perform the medical math to administer D50W or Glucagon in the classroom setting, demonstrate how a D50W pre-load is assembled a ...
Endo Exam - Teddie Joe Snodgrass
... should be injected 30 minutes before the meal. If the rapid-acting portion is aspart (NovoLog), it can be injected 5 – 15 minutes before the meal. It is a less flexible dosing pattern than basal-bolus because the client is required to eat midday or suffer hypoglycemia. In this case, the pre-dinner g ...
... should be injected 30 minutes before the meal. If the rapid-acting portion is aspart (NovoLog), it can be injected 5 – 15 minutes before the meal. It is a less flexible dosing pattern than basal-bolus because the client is required to eat midday or suffer hypoglycemia. In this case, the pre-dinner g ...
Case Report Severe Hypoglycemia Accompanied with
... 17.3 mg/mL). Our case showed severe congestive heart failure (EF = 53.8%, IVC = 25.9 mm, respiratory changes did not occur) and liver dysfunction with icterus. Therefore, we believe that hypoglycemia may have been caused by congestive heart failure and liver dysfunction. Although lactic acid was not ...
... 17.3 mg/mL). Our case showed severe congestive heart failure (EF = 53.8%, IVC = 25.9 mm, respiratory changes did not occur) and liver dysfunction with icterus. Therefore, we believe that hypoglycemia may have been caused by congestive heart failure and liver dysfunction. Although lactic acid was not ...
Hyperinsulinemic Hypoglycemia After Gastric
... were deliberately selected for a short period between death and autopsy and were screened to exclude those with autolysis as described in detail before (20). The ideal controls for these studies would be pancreata from the majority of people who undergo GBS without developing hypoglycemia. However, ...
... were deliberately selected for a short period between death and autopsy and were screened to exclude those with autolysis as described in detail before (20). The ideal controls for these studies would be pancreata from the majority of people who undergo GBS without developing hypoglycemia. However, ...
insulin and glucagon responses in the hibernating black bear
... hibernation were significantly decreased, a finding consistent with previous reports of protein conservation during hibernation (Nelson et al. 1975, Lundberget al. 1976). Basal levels of glucagon and corticosteroids tended to be higher during hibernation, which is consistent with the adaptationof th ...
... hibernation were significantly decreased, a finding consistent with previous reports of protein conservation during hibernation (Nelson et al. 1975, Lundberget al. 1976). Basal levels of glucagon and corticosteroids tended to be higher during hibernation, which is consistent with the adaptationof th ...
Glucose production by the human kidney—its importance has been
... This traditional textbook view of the human kidney releasing insignificant amounts of glucose was based on net balance data of glucose, i.e. the mathematical product of arteriorenal venous difference of glucose concentrations (obtained through a sampling catheter in a renal vein) and renal blood flo ...
... This traditional textbook view of the human kidney releasing insignificant amounts of glucose was based on net balance data of glucose, i.e. the mathematical product of arteriorenal venous difference of glucose concentrations (obtained through a sampling catheter in a renal vein) and renal blood flo ...
Impact of recurrent hypoglycemic stress on hindbrain A2 nerve cell
... hypoglycemia‑associated nerve cell Fos immunostaining in the DVC (Nedungadi et al. 2006). Estradiol may thus prevent cellular energy state adjustments over serial hypoglycemic bouts or, alternatively, may mask acquired cellular energy instability by promoting signals of energy balance. A2 neurons ar ...
... hypoglycemia‑associated nerve cell Fos immunostaining in the DVC (Nedungadi et al. 2006). Estradiol may thus prevent cellular energy state adjustments over serial hypoglycemic bouts or, alternatively, may mask acquired cellular energy instability by promoting signals of energy balance. A2 neurons ar ...
The microflow LC method
... Non-specific binding to glass or stainless steel components can be a concern during peptide analysis, particularly for longer, hydrophobic peptides, like glucagon. To evaluate sample absorption during peptide extraction and quantitation, glucagon levels were monitored over time in different vial typ ...
... Non-specific binding to glass or stainless steel components can be a concern during peptide analysis, particularly for longer, hydrophobic peptides, like glucagon. To evaluate sample absorption during peptide extraction and quantitation, glucagon levels were monitored over time in different vial typ ...
Strict Glucose Control Does Not Affect Mortality
... patients were admitted with the primary diagnosis of aneurysmal subarachnoid hemorrhage (preprotocol). Between January 1, 2002, and December 31, 2007, 491 patients were admitted (postprotocol). The median average glucose for all patients before initiation of the glucose control protocol was 121 mg/d ...
... patients were admitted with the primary diagnosis of aneurysmal subarachnoid hemorrhage (preprotocol). Between January 1, 2002, and December 31, 2007, 491 patients were admitted (postprotocol). The median average glucose for all patients before initiation of the glucose control protocol was 121 mg/d ...
Glucose Metabolism and Regulation: Beyond Insulin and Glucagon
... enzyme dipeptidyl peptidase-IV (DPPGLP-1 also stimulates glucoseIV), which rapidly cleaves and inactidependent insulin secretion but is sigvates GLP-1. nificantly reduced postprandially in Infusion of GLP-1 lowers postpranpeople with type 2 diabetes or dial glucose as well as overnight fastimpaired ...
... enzyme dipeptidyl peptidase-IV (DPPGLP-1 also stimulates glucoseIV), which rapidly cleaves and inactidependent insulin secretion but is sigvates GLP-1. nificantly reduced postprandially in Infusion of GLP-1 lowers postpranpeople with type 2 diabetes or dial glucose as well as overnight fastimpaired ...
Chapter 37 - BristolPlymouth21stCenturyHealth
... amounts but insulin receptors in target cells insensitive or resistant to insulin Common in overweight clients and those having low HDL-cholesterol and high triglyceride levels ...
... amounts but insulin receptors in target cells insensitive or resistant to insulin Common in overweight clients and those having low HDL-cholesterol and high triglyceride levels ...
Brain glucose concentrations in poorly controlled diabetes mellitus
... 1 diabetes does appear to affect brain glucose transport and/or metabolism in human beings. We recently observed that brain glucose concentrations are significantly higher in patients with type 1 diabetes, recurrent and frequent hypoglycemia, and hypoglycemia unawareness than in control subjects stu ...
... 1 diabetes does appear to affect brain glucose transport and/or metabolism in human beings. We recently observed that brain glucose concentrations are significantly higher in patients with type 1 diabetes, recurrent and frequent hypoglycemia, and hypoglycemia unawareness than in control subjects stu ...
Assessment and monitoring of glycemic control in children and
... individual an HbA1c as close to the normal range as possible. Both hypoglycemia and hyperglycemia may result in central nervous system (CNS) alterations, both acutely and chronically. Lower HbA1c levels may be associated with an increase in episodes of severe hypoglycemia (1, 2) (A). Severe hypoglyc ...
... individual an HbA1c as close to the normal range as possible. Both hypoglycemia and hyperglycemia may result in central nervous system (CNS) alterations, both acutely and chronically. Lower HbA1c levels may be associated with an increase in episodes of severe hypoglycemia (1, 2) (A). Severe hypoglyc ...
Diabetes Mellitus
... • Desiccated thyroid used infrequently due to inconsistent dosing • Angina can occur when thyroid replacement is initiated as it enhances effects of cardiovascular catecholamines (in pt. w/preexistent CAD). Start at low dose. • Hypnotics and sedatives may have profound effects on sensorium ...
... • Desiccated thyroid used infrequently due to inconsistent dosing • Angina can occur when thyroid replacement is initiated as it enhances effects of cardiovascular catecholamines (in pt. w/preexistent CAD). Start at low dose. • Hypnotics and sedatives may have profound effects on sensorium ...
PITUITARY FUNCTION TESTS: An Overview
... • Results of IST should be rejected if hypoglycemia (2.2mmol/L or lower blood glucose level) was not achieved during the test; In apparently healthy individuals, Hypoglycemia causes: • Increase in Plasma [HGH] to more than 20m U/L; • Plasma [Cortisol] increases to maximum (about 425nmol/L) in 60 to ...
... • Results of IST should be rejected if hypoglycemia (2.2mmol/L or lower blood glucose level) was not achieved during the test; In apparently healthy individuals, Hypoglycemia causes: • Increase in Plasma [HGH] to more than 20m U/L; • Plasma [Cortisol] increases to maximum (about 425nmol/L) in 60 to ...
Diabetes Mellitus in Pregnancy Screening and Management
... The second phase is a 75-g OGTT at 24–28 weeks' gestation in all women not previously found to have overt diabetes or GDM. Table 2 presents the 2010 International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria based on the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) stud ...
... The second phase is a 75-g OGTT at 24–28 weeks' gestation in all women not previously found to have overt diabetes or GDM. Table 2 presents the 2010 International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria based on the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) stud ...
- KoreaMed Synapse
... absorption of calcium and phosphorus into the blood. The conversion of vitamin D2 or D3 to its active form is stimulated by PTH. Deficiencies of sunlight, milk or milk products, malabsorption of vitamin D, failure to activate vitamin D, or tissue unresponsiveness to vitamin D can predispose the chil ...
... absorption of calcium and phosphorus into the blood. The conversion of vitamin D2 or D3 to its active form is stimulated by PTH. Deficiencies of sunlight, milk or milk products, malabsorption of vitamin D, failure to activate vitamin D, or tissue unresponsiveness to vitamin D can predispose the chil ...
Diabetic hypoglycemia
Diabetic hypoglycemia is a low blood glucose level occurring in a person with diabetes mellitus. It is one of the most common types of hypoglycemia seen in emergency departments and hospitals. According to the National Electronic Injury Surveillance System-All Injury Program (NEISS-AIP), and based on a sample examined between 2004 and 2005, an estimated 55,819 cases (8.0% of total admissions) involved insulin, and severe hypoglycemia is likely the single most common event.In general, hypoglycemia occurs when a treatment to lower the elevated blood glucose of diabetes inaccurately matches the body's physiological need, and therefore causes the glucose to fall to a below-normal level.