Gene Section ACVR2A (activin A receptor, type IIA) in Oncology and Haematology
... contains a polyadenine tract that may be mutated in microsatellite unstable cells. ...
... contains a polyadenine tract that may be mutated in microsatellite unstable cells. ...
Regulation of carbohydrate metabolism Intracellular - Rose
... Diabetes mellitus is a relatively common disorder resulting either from destruction of the cells that release insulin or from lack of response to insulin by the tissues. The absence of insulin action results in a condition that is similar to starvation; tissues are broken down to provide substrates ...
... Diabetes mellitus is a relatively common disorder resulting either from destruction of the cells that release insulin or from lack of response to insulin by the tissues. The absence of insulin action results in a condition that is similar to starvation; tissues are broken down to provide substrates ...
Divergent Evolution of ( )8-Barrel Enzymes
... domain that is formed by the N- and C-terminal parts of the sequence (Babbitt et al., 1996). The mixed α/β domain is an important determinant of the substrate specificity and caps the barrel domain at the C-terminal ends of the β-strands, where the residues that are essential for catalysis are locat ...
... domain that is formed by the N- and C-terminal parts of the sequence (Babbitt et al., 1996). The mixed α/β domain is an important determinant of the substrate specificity and caps the barrel domain at the C-terminal ends of the β-strands, where the residues that are essential for catalysis are locat ...
Chapter 3: Enzymes: Structure and Function
... locations on the enzyme surface that can accept substrates and cofactors. The enzyme contains amino acids that interact with the substrate and cofactor in the usual way (ionic interactions, H bonds, dipole-dipole, dispersion forces and covalent bonds) which all help repeatedly catalyze the reaction ...
... locations on the enzyme surface that can accept substrates and cofactors. The enzyme contains amino acids that interact with the substrate and cofactor in the usual way (ionic interactions, H bonds, dipole-dipole, dispersion forces and covalent bonds) which all help repeatedly catalyze the reaction ...
of membrane lipids
... • Always attached to a C-terminal residue • Ethanolamine link to an oligosaccharide linked in turn to inositol of PI • See Figure 9.20 • Examples: surface antigens, adhesion molecules, cell surface hydrolases ...
... • Always attached to a C-terminal residue • Ethanolamine link to an oligosaccharide linked in turn to inositol of PI • See Figure 9.20 • Examples: surface antigens, adhesion molecules, cell surface hydrolases ...
Adrenergic Transmission
... number of large dense-cored vesicles located farther from the synaptic membrane. The large vesicles contain a high concentration of peptide cotransmitters, while the smaller clear vesicles contain most of the acetylcholine. Vesicles are initially synthesized in the neuron soma and transported to the ...
... number of large dense-cored vesicles located farther from the synaptic membrane. The large vesicles contain a high concentration of peptide cotransmitters, while the smaller clear vesicles contain most of the acetylcholine. Vesicles are initially synthesized in the neuron soma and transported to the ...
Analysis - The Journal of Cell Biology
... Identification and Classification of Drosophila Protein Kinases and Phosphatases Our survey of Drosophila protein kinases and phosphatases is based on the total set of predicted proteins that were identified in the Drosophila genome using automated gene predictor methods (Adams et al., 2000; availab ...
... Identification and Classification of Drosophila Protein Kinases and Phosphatases Our survey of Drosophila protein kinases and phosphatases is based on the total set of predicted proteins that were identified in the Drosophila genome using automated gene predictor methods (Adams et al., 2000; availab ...
A Comparative Genomic Method for Computational
... • DnaA regulation may couple lipid cellular processes to DNA replication – this may be accomplished by the transcription factor activity of DnaA upstream of phospholipid biosynthesis genes fadL, acpP, fabF, accD, plsC, psd, and pgsA – changes in expression of the phospholipid biosynthesis proteins a ...
... • DnaA regulation may couple lipid cellular processes to DNA replication – this may be accomplished by the transcription factor activity of DnaA upstream of phospholipid biosynthesis genes fadL, acpP, fabF, accD, plsC, psd, and pgsA – changes in expression of the phospholipid biosynthesis proteins a ...
Gene Section ABL1 (v-abl Abelson murine leukemia viral oncogene homolog 1)
... inhibitory role. The autoregulatory mechanism remains functional in the cytoplasmic and nuclear form of c-abl. The latter is also negatively regulated by Rb in the Gphase of the cell cycle. Beside the structural autoinhibition, several cellular proteins have been shown to inhibit c-ABL: Pag (or Pero ...
... inhibitory role. The autoregulatory mechanism remains functional in the cytoplasmic and nuclear form of c-abl. The latter is also negatively regulated by Rb in the Gphase of the cell cycle. Beside the structural autoinhibition, several cellular proteins have been shown to inhibit c-ABL: Pag (or Pero ...
Human Physiology 1-L..
... 1. Diagram the structure of the plasma membrane indicating where carbohydrates, fats, and proteins are found within and on the plasma membrane. 2. Explain/differentiate the functions of carbohydrates, fats, and proteins found within and on the plasma membrane. 3. Predict the function of a cell based ...
... 1. Diagram the structure of the plasma membrane indicating where carbohydrates, fats, and proteins are found within and on the plasma membrane. 2. Explain/differentiate the functions of carbohydrates, fats, and proteins found within and on the plasma membrane. 3. Predict the function of a cell based ...
Supporting Information Legends Figure S1. Lipid and fatty acid
... and 18:1ω9 (Olsson & Johansen, 2000). ASG, acylated sterol glycosides; DAG, diacylglycerol; FFA, free fatty acids; FS, free sterol; GlcCer, glycosylceramide; MAG, monoacyldiacylglycerol; PA, phosphatidic acid; PC, phosphatidylcholine; PE, phosphatidylethanolamine; PI, phosphatidylinositol; PS, phosp ...
... and 18:1ω9 (Olsson & Johansen, 2000). ASG, acylated sterol glycosides; DAG, diacylglycerol; FFA, free fatty acids; FS, free sterol; GlcCer, glycosylceramide; MAG, monoacyldiacylglycerol; PA, phosphatidic acid; PC, phosphatidylcholine; PE, phosphatidylethanolamine; PI, phosphatidylinositol; PS, phosp ...
ICBEnzyEvol
... • Rate of synonymous substitution varies considerably from gene to gene • Many enzymes, inspite of being proteins in nature, do not provide the valid results • Accuracy rate is about 50% to 55%. • Nonsynonymous sites were too high for some cases, so no valid result. ...
... • Rate of synonymous substitution varies considerably from gene to gene • Many enzymes, inspite of being proteins in nature, do not provide the valid results • Accuracy rate is about 50% to 55%. • Nonsynonymous sites were too high for some cases, so no valid result. ...
The Glutamate Receptor Subunit 1 Is Highly Expressed in Hair Cells
... Similar studies have suggested that the vestibular afferent neurotransmitter is an excitatory amino acid (Annoni et al., 1984; Soto and Vega, 1988; Bledsoe et al., 1989). In the CNS, glutamate mediates most fast excitatory synaptic transmission via activation of three major families of ionotropic re ...
... Similar studies have suggested that the vestibular afferent neurotransmitter is an excitatory amino acid (Annoni et al., 1984; Soto and Vega, 1988; Bledsoe et al., 1989). In the CNS, glutamate mediates most fast excitatory synaptic transmission via activation of three major families of ionotropic re ...
Energy Metabolism - Georgia Institute of Technology
... – Metabolized in cytoplasm to pyruvate – Co-transported to matrix with H+ – Bound to Coenzyme A as Acetyl-CoA ...
... – Metabolized in cytoplasm to pyruvate – Co-transported to matrix with H+ – Bound to Coenzyme A as Acetyl-CoA ...
Endocrinology – glucose homeostasis
... liver. It does this by inhibiting glycogenolysis, by stimulating glucose uptake / glycolysis / glycogen synthesis, and by indirectly inhibiting gluconeogenesis via inhibition of fatty acid mobilization from adipose tissue. Second, it increases the rate of uptake of glucose into all insulin-sensitive ...
... liver. It does this by inhibiting glycogenolysis, by stimulating glucose uptake / glycolysis / glycogen synthesis, and by indirectly inhibiting gluconeogenesis via inhibition of fatty acid mobilization from adipose tissue. Second, it increases the rate of uptake of glucose into all insulin-sensitive ...
Fatty Acid Catabolism - Chemistry Courses: About
... part by Franz Knoop in 1904. He fed dogs fatty acid phenyl derivatives and then analyzed their urine for the resulting metabolites. What metabolite was produced when dogs were fed ...
... part by Franz Knoop in 1904. He fed dogs fatty acid phenyl derivatives and then analyzed their urine for the resulting metabolites. What metabolite was produced when dogs were fed ...
Lecture 33
... The activities of PFK-1 and FBPase-1 are regulated by the allosteric effectors AMP, citrate and fructose-2,6-bisphosphate (F-2,6-BP), but in a reciprocal manner. Reciprocal regulation refers to the fact that the same regulatory molecule has opposite effects on two enzymes that control a shared step ...
... The activities of PFK-1 and FBPase-1 are regulated by the allosteric effectors AMP, citrate and fructose-2,6-bisphosphate (F-2,6-BP), but in a reciprocal manner. Reciprocal regulation refers to the fact that the same regulatory molecule has opposite effects on two enzymes that control a shared step ...
Regulation of hepatic metabolism by AMPK - HAL
... thereby reducing CREB-dependent expression of the gluconeogenesis genes [1], although this effect was recently challenged [2]. (6) AMPK activation also inhibits other ATP-consuming anabolic pathways such as protein synthesis. This occurs by multiple mechanisms including inhibition of the mTOR/S6K1 p ...
... thereby reducing CREB-dependent expression of the gluconeogenesis genes [1], although this effect was recently challenged [2]. (6) AMPK activation also inhibits other ATP-consuming anabolic pathways such as protein synthesis. This occurs by multiple mechanisms including inhibition of the mTOR/S6K1 p ...
Enzymes in Food Technology
... Lactase is used commercially to prepare lactose-free products, particularly milk, for such individuals. It is also used in preparation of ice cream, to make a creamier and sweeter-tasting product. Lactase is usually prepared from Kluyveromyces sp. of yeast and Aspergillus sp. of fungi. ...
... Lactase is used commercially to prepare lactose-free products, particularly milk, for such individuals. It is also used in preparation of ice cream, to make a creamier and sweeter-tasting product. Lactase is usually prepared from Kluyveromyces sp. of yeast and Aspergillus sp. of fungi. ...
Smooth endoplasmic reticulum
... Synthesis of steroid hormones The synthesis of the steroid hormones is based upon the modification of cholesterol by the SER. In mammals the mitochondria are also directly involved. Many of the reactions involve the addition of hydroxyl groups (which may then oxidized to form carbonyl groups). The c ...
... Synthesis of steroid hormones The synthesis of the steroid hormones is based upon the modification of cholesterol by the SER. In mammals the mitochondria are also directly involved. Many of the reactions involve the addition of hydroxyl groups (which may then oxidized to form carbonyl groups). The c ...
UNIT 3 – PHOTOSYNTHESIS AND CELLULAR RESPIRATION
... provide about 1/3rd less energy than NADH molecules. The electron transport is coupled on the inner membrane of the mitochondrion with another process called chemiosmosis. ...
... provide about 1/3rd less energy than NADH molecules. The electron transport is coupled on the inner membrane of the mitochondrion with another process called chemiosmosis. ...
Plant hormone receptors: new perceptions
... The TIR1 and AFB proteins are nuclear localized and exhibit typical F-box protein architecture, having an Nterminal F-box domain that mediates interactions with the SKP1 SCF subunit, followed by a series of leucinerich repeats (LRRs) that comprise the substrate-binding domain. Crucial insight into h ...
... The TIR1 and AFB proteins are nuclear localized and exhibit typical F-box protein architecture, having an Nterminal F-box domain that mediates interactions with the SKP1 SCF subunit, followed by a series of leucinerich repeats (LRRs) that comprise the substrate-binding domain. Crucial insight into h ...
Exam Procedures: this isBMB 514 Exam #2 10/8/12 this is form A
... Cholesterol esterification increases its polarity making it more water soluble Low density lipoproteins are called bad cholesterol because they can esterify cholesterol High density lipoproteins are solely responsible for cholesterol excretion All cholesterol is transported in the esterified form. A ...
... Cholesterol esterification increases its polarity making it more water soluble Low density lipoproteins are called bad cholesterol because they can esterify cholesterol High density lipoproteins are solely responsible for cholesterol excretion All cholesterol is transported in the esterified form. A ...
Document
... • Storage and release of acetylcholine (ACh) • the nerve cells that bring messages contain ACh stored in vesicles • the receptors on muscle neurons are called nicotinic receptors because nicotine inhibits them • the message is initiated by calcium ions, Ca2+ • when Ca2+ concentration becomes more th ...
... • Storage and release of acetylcholine (ACh) • the nerve cells that bring messages contain ACh stored in vesicles • the receptors on muscle neurons are called nicotinic receptors because nicotine inhibits them • the message is initiated by calcium ions, Ca2+ • when Ca2+ concentration becomes more th ...
Word
... Cholesterol esterification increases its polarity making it more water soluble Low density lipoproteins are called bad cholesterol because they can esterify cholesterol High density lipoproteins are solely responsible for cholesterol excretion All cholesterol is transported in the esterified form. A ...
... Cholesterol esterification increases its polarity making it more water soluble Low density lipoproteins are called bad cholesterol because they can esterify cholesterol High density lipoproteins are solely responsible for cholesterol excretion All cholesterol is transported in the esterified form. A ...
Lipid signaling
Lipid signaling, broadly defined, refers to any biological signaling event involving a lipid messenger that binds a protein target, such as a receptor, kinase or phosphatase, which in turn mediate the effects of these lipids on specific cellular responses. Lipid signaling is thought to be qualitatively different from other classical signaling paradigms (such as monoamine neurotransmission) because lipids can freely diffuse through membranes (see osmosis.) One consequence of this is that lipid messengers cannot be stored in vesicles prior to release and so are often biosynthesized ""on demand"" at their intended site of action. As such, many lipid signaling molecules cannot circulate freely in solution but, rather, exist bound to special carrier proteins in serum.