Download Bio 309F

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Bio 309F
Examination #1
February 20, 2007
Name______ __________________________________
Note: please place your name, course unique number (49790, 49795, 49800, 49805, 49810), and
bubble in your answers on the scantron. We will only grade the scantron so double check to be sure
the answers on the scantron are as you want them. Through out the exam, please cover your answers.
Do not use electronic gadgets, including telephone--so, please turn off your telephone prior to starting
the exam. Turn in both the scantron and the exam.
I. Multiple Choice, scan in the best answer (50 questions, 2 pts each, 100 pts total)
1. A large, membrane-bounded region of a human cell that houses DNA is called
A. golgi apparatus
D. nucleus
B. endoplasmic reticulum
E. cenriole
C. lysosome
2. Function of mitochondria is:
A. provides structure to a cell
B. assists in the break down and disposal of cellular components
C. displays cell membrane receptors
D. extracts energy from nutrients
E. involved in making proteins
3. DNA is replicated in the _________ phase of the cell cycle
A. interphase
D. anaphase
B. prophase
E. telophase
C. metaphase
4. The stage of mitosis when chromosomes align along the center of the cell is called
A. interphase
D. anaphase
B. prophase
E. telophase
C. metaphase
5. A defect in which organelle would cause fatigue?
A. lysosome
D. endoplasmic reticulum
B. centriole
E. golgi apparatus
C. mitochondria
6. Events/results that occur in meiosis
A. homologous chromosomes pair
B. crossing-over between homologous chromosomes
C. crossing-over between non-homologous chromosomes
D. A and B are correct
E. A and C are correct
7. Spermatogenesis of a single human spermatocyte results in
A. 4 diploid gametes
B. 4 haploid gametes
C. gametes that contain 23 chromosomes
D. A and C are correct
E. B and C are correct
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8. The separation of members of a gene pair during gamete formation is called
A. principle of independent assortment
B. principle of non-disjunction
C. principle of segregation
D. principle of dominance and recessiveness
E. principle of cell division
9. A diploid human somatic cell (from normal individual) will contain ________ chromosomes
A. 23 chromosomes
D. 46 chromosomes
B. 44 chromosomes
E. 47 chromosomes
C. 45 chromosomes
10. How many autosomes are in a somatic cell of a normal human being?
A. 23 chromosomes
D. 46 chromosomes
B. 44 chromosomes
E. 47 chromosomes
C. 45 chromosomes
11. A human oocyte (egg) from a normal woman will contain ________chromosomes.
A. 23 chromosomes
D. 46 chromosomes
B. 24 chromosomes
E. 47 chromosomes
C. 45 chromosomes
12. A somatic cell from a Turner syndrome individual will contain ___chromosomes.
A. 23 chromosomes
D. 46 chromosomes
B. 24 chromosomes
E. 47 chromosomes
C. 45 chromosomes
13. A somatic cell from a Klinefelter syndrome individual will contain ___chromosomes.
A. 23 chromosomes
D. 46 chromosomes
B. 24 chromosomes
E. 47 chromosomes
C. 45 chromosomes
Note: Consider the following information regarding autosomal recessive inheritance for questions
14- 17 C = normal, c = cystic fibrosis)
14. A couple who do not have cystic fibrosis have a cystic fibrosis child. What are the genotypes of
the parents?
Mother
Father
A.
CC
cc
B.
Cc
CC
C.
cc
Cc
D.
Cc
Cc
E.
cc
cc
15. The couple from question # 14 are expecting another child. What are the chances that this
expected child will have cystic fibrosis?
A. 0%, no chance
B. 1/4 (25%) chance
C. 3/4 (75% chance)
D. 1/2 (50% chance
E. 4/4 (100% chance).
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16. What are the chances that the expected child from question # 15 will be normal (i.e., will not
have cystic firbosis?
A. 0%, no chance
D. 1/2 (50% chance)
B. 1/4 (25%) chance
E. 4/4 (100% chance)
C. 3/4 (75% chance)
17. The child from question #15 is born and is normal (i.e. does not have cystic fibrosis). What are
the chances that this normal child will be heterozygous for the cystic fibrosis trait?
A. 1/3
D. 1/2
B. 2/3
E. 3/4
C. 1/4
[Note: Consider this new autosomal recessive mode of inheritance information along with the cystic
fibrosis information from above for questions 18-24: A = normal pigmentation, a = albino.]
18. A couple normal for pigmentation and normal for the cystic fibrosis trait have an albino child
who has cystic fibrosis. What are the genotypes of the parents?
Mother
Father
A.
Aacc
AaCc
B.
AaCc
AaCC
C.
AaCc
AaCc
D.
Aacc
aaCc
E.
aacc
AACC
19. What is the genotype of the child from question # 18?
A. AACC
D. AaCc
B. AaCC
E. aacc
C. AACc
20. The couple from question # 18 are expecting another child. What is the probability that this
expected child will be a cystic fibrosis albino?
A. 1/4
D. 9/16
B. 3/4
E. 1/16
C. 3/16
21. What is the probability that this same expected child from question #18 will be an albino but
will be normal for cystic fibrosis?
A. 1/4
D. 9/16
B. 3/4
E. 1/16
C. 3/16
22. What is the probability that this same expected child from question # 18 will have normal
pigmentation but will have cystic fibrosis?
A. 1/4
D. 9/16
B. 3/4
E. 1/16
C. 3/16
23. What is the probability that this same expected child from question # 18 will be normal for both
traits?
A. 1/4
D. 9/16
B. 3/4
E. 1/16
C. 3/16
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24. What is the probability that this same expected child from question # 18 will be homozyous for
both normal traits, that is AACC?
A. 1/4
B. 3/4
C. 3/16
D. 9/16
E. 1/16
Note: Consider the following infromation regarding X-linked recessive inheritance for questions (
25-27) : H = normal blood clotting, h = hemophilia.
25. A couple with normal blood clotting have a hemophiliac son. What are the genotypes of the
parents?
Mother
Father
A.
Hh
Hh
B.
HH
Hy
C.
Hh
Hy
D.
hh
Hy
E.
hh
hy
26. The couple from question # 25 have a new baby daughter. What is the probability that the
daughter will have hemophilia?
A. 0%
B. 25%
C. 50%
D. 75%
E. 100%
27. The couple from question #25 have a third child, a normal daughter. What is the probability that
this normal daughter is a carrier for the hemophilia trait?
A. 0%
B. 25%
C. 50%
D. 75%
E. 100%
28. A man who is normal for blood clotting, but who’s mother was a carrier of the hemophilia trait seeks
information on whether or not he will transmit the hemophilia trait to his children. What would you tell him?
A. he will transmit the hemophilia allele to all of his children
B. he will transmit the hemophilia allele only to his daughters
C. he will transmit the hemophilia allele only to his sons
D. A, B, and C are correct
E. none of the above are correct
29. Why have geneticists been able to identify several genes linked to the X chromosome in humans?
A. the X chromosome is much easier to identify than the other chromosomes.
B. the X chromosome is one of the smaller chromosomes, therefore easier to study
C. only dominant genes are localized on the X chromosome
D. recessive genes on an X chromosome are carried (in a hidden fashion) by the normal mother and are
expressed in her sons but not her daughters .
E. None of the above
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30. The father has a particular genetic trait, the mother is normal for this trait. They have four
chidren, two boys and two girls. A son and a daughter have the trait of their father and the other son
and daughter are normal like their mother. What is the mode of inheritance for this trait?
A. autosomal recessive
B. autosomal dominant
C. sex-linked recessive
D. sex-linked dominant
E. A & B could be the correct mode of inheritance
WE ACCEPTED ALL ANSWERS FOR THIS QUESTIONS, AS A, B, OR C COULD’VE BEEN
THE CORRECT ANSWER
For questions #31-34, assume the traits follow Mendelian inheritance, with a capital letter as the
dominant allele and lowercase letter as the recessive allele
31. Which of the following crosses would give a 3:1 phenotypic ratio?
A. AaBb X AaBb
B. AaBb X Aabb
C. AaBb X aabb
D. Aa X Aa
E. Aa X aa
32. Which of the following crosses would give a 9:3:3:1 phenotypic ratio?
A. AaBb X AaBb
B. AaBb X Aabb
C. AaBb X aabb
D. Aa X Aa
E. Aa X aa
33. Which of the following crosses would give a 1:1 phenotypic/genotypic ratio?
A. AaBb X AaBb
B. AaBb X Aabb
C. AaBb X aabb
D. Aa X Aa
E. Aa X aa
34. Which of the following crosses would give a 1:2:1 genotypic ratio?
A. AaBb X AaBb
B. AaBb X Aabb
C. AaBb X aabb
D. Aa X Aa
E. Aa X aa
35. Which of the following traits is inherited as co-dominance?
A. eye color
B. A B blood type
C. ability to roll the tongue
D. red, white and pink snapdragon flower color
E. hereditary deafness
36. Which of the following traits is inherited as incomplete dominance?
A. eye color
B. A B blood type
C. ability to roll the tongue
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D. red, white and pink snapdragon flower color
E. hereditary deafness
37. Sickle cell anemia is a genetic disorder caused by a genetic defect (mutation) in
A. cell membrane gene
B. hemoglobin gene
C. LDL receptor
D. mitochondria
E. none of the above
38. Polygenic trait is
A. determined in a Mendelian fashion
B. determined by more than one gene
C. varies continuously in expression
D. evaluated by measuring populations rather than individuals
E. B, C, and D are correct
39. Polygenic traits with a strong environmental component are called
A. intermediate traits
B. dominant/recessive traits
C. co-dominant traits
D. multifactorial traits
E. none of the above
40. Heritability:
A. estimates the proportion of variation in a multifactorial trait that is attributable to genetic variation
B. estimates the proportion of variation in a multifactorial trait that is attributable to environmental variation
C. describes a trait in a particular population at a particular time
D. A and C are correct
E. B and C are correct
41. Dizygotic twins
A. Are as closely related as monozygotic twins
B. are as closely related as non-twin siblings
C. share 100% of their genetic material
D. share 25% of their genetic material
E. none of the above
42. Human chromosomes are identified on the basis of
A. size
B. location of centromere
C. specific areas of heterochromatin staining
D. specific areas of euchromatin staining
E. all of the above
43. Technique for identifying individual chromosomes based on binding fluorescently labeled DNA probes to
complemenatary sequences on a chromosome is referred to as
A. FACS
B. FITC
C. FARM
D. FISH
E. none of the above
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44. Karyotypic profiles on developing fetuses can be determined by procedure(s) called
A. aminocentesis
B. chorionic villus sampling
C. fetal cell sorting
D. A and B are correct
E. A, B, and C are correct
45. Aneuploidy can result from
A. nondisjunction occurring in meiosis I in females
B. nondisjunction occurring in meiosis II in females
C. nondisjunction occurring in meiosis I in males
D. nondisjunction occurring in meiosis II in males
E. A, B, C, and D are correct
46. Down syndrome individuals can be referred to as
A. euploidy
B. triploidy
C. diploidy
C. monosomic
E. trisomic
47. Which of the following is/are example(s) of sex chromosome aneuploids?
A. Down syndrome
B. Turner syndrome
C. Klinefelter syndrome
D. triple X or triplo-X
E. B, C and D are correct
48. Although a rare event, individuals can have 23 pairs of chromosomes (46), receiving one pair of
chromosomes from one parent: i.e. egg with chromosomes (an extra #7 chromosome) and sperm with 22
chromosomes (missing a # 7 chromosome). Such an event is referred to as
A. uniparental disomy
B. uniparental monosomy
C. uniparental trisomy
D. uniparental triploidy
E. none of the above
49. How many chromosomes would a person have who has Klinefelter syndrome and also trisomy 21?
A. 44
B. 45
C. 46
D. 47
E. 48
50. Down syndrome (also Turner syndrome) can result from
A. trisomy
B. translocation
C. mosaic
D. A and B are correct
E. A, B, and C are correct
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