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Transcript
CYSTIC FIBROSIS PEDIGREE Cystic fibrosis is a genetic disorder. Individuals with CF have an excess amount of fluid produced in their lungs, leading to severe respiratory problems. People with CF often die within their first year of life. The gene for CF is not found on the sex chromosomes. Therefore, males and females will each have two CF alleles in their genotype. The dominant allele for cystic fibrosis gene is “F”, for normal fluid. The recessive allele is “f” for too much fluid. Heterozygotes, “Ff”, have the normal amount of fluid in their lungs. Heterozygotes are also called carriers of the CF gene because even though they do not have the disease, they can pass the recessive allele to their offspring. STEP 1: Complete the key to the right of the pedigree by coloring in appropriate circles and boxes and by writing the appropriate genotypes (FF, Ff or ff). STEP 2: Use the pedigree to answer the analysis questions. KEY 1 2 normal female, ____ affected female, ____ 3 4 5 6 normal male, ____ affected male, ____ 7 8 1. How many generations are represented in the pedigree? _________ 2. How many offspring did the first couple have? __________ 3. How many males have CF? _______ How many females have CF? _______ 4. What is the genotype of individual 4? _______ 5. Which individuals must be carriers of the recessive CF allele? ____________ 6. A woman and man are both heterozygous for the CF gene. They want to have a child but are worried that their baby will inherit CF. What is the likelihood that their baby will be affected by CF? Use a Punnett Square to support your conclusions. DIRECTIONS: For each pedigree, use the key and alleles to determine the genotypes of the unnumbered individuals. Write individual genotypes on the lines provided. PEDIGREE 1: Dominant Trait: Huntington’s Disease (H,h) KEY 2 1 normal female affected female 5 4 3 normal male affected male 6 Genotypes: 1. ______ 2. ______ 3. ______ 4. ______ 5. ______ 6. ______ PEDIGREE 2: Codominant Trait: Blood Type (A, B, O) AB Genotypes: A 1 B A B 2 3 B 4 O A 9 B O 5 6 A B A 7 8 AB O O 1. ________ 7. ________ 2. ________ 8. ________ 3. ________ 9. ________ 4. ________ 10. ________ 5. ________ 11. ________ 6. ________ 12. ________ AB A B 10 11 O B 12