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ID _________________________________
PSYC 3102: Intro to Behavioral Genetics (Carey)
Exam 2
Multiple Choice
The purpose of linkage analyses is to:
a) determine the exact location of a gene
b) determine the approximate location of a marker
c) determine the approximate location of a gene
d) determine the exact location of a marker
e) none of the above
_____
An RFLP is:
a) a Repetitive Family Linked Polymorphism
b) a Ribosomal Fat LipoProtein
c) a Recombination Frequency Linkage Probe
d) a Restriction Fragment Length Polymorphism
e) a Repetitive Frequently Linked Primer
_____
A karyotype is:
a) an observable phenotype
b) an observable genotype
c) monosomy of a chromosome
d) a picture of stained chromosomes
e) trisomy of a chromosome
_____
Down’s syndrome is characterized by:
a) Alzheimer’s-like pathology
b) abnormal fingerprints and palmprints
c) protruding mouth
d) increased leukemia risk
e) all of the above
_____
A DCG is:
a) a Disease with CG repeats
b) a Disorder with Chromosomal Gaps
c) a Disorder with Complex Genetics
d) a Disease that is Completely Genetic
e) none of the above
_____
A major locus for a disorder:
a) determines whether or not a person will get the disorder
b) causes a phenocopy
_____
c) is a marker used in linkage analyses
d) is a Mendelizing form of the disorder
e) has a relatively large effect on the disorder
Individuals with William’s syndrome tend to:
a) have an elfish appearance
b) have impaired non-verbal abilities
c) have normal verbal abilities
d) have musical ability
e) none of the above
_____
Mendel’s law of segregation states that:
a) some hereditary factors dominate others
b) each parent passes 1 of 2 hereditary factors at random to offspring
c) linked loci are transmitted as a unit
d) hereditary factors for one trait are transmitted independent of those for another trait
e) all of the above
_____
Prader-Willi syndrome:
a) is caused by the same chromosomal abnormality that causes Angelman’s Syndrome
b) is caused by inheritance of a microdeletion from the father
c) is characterized by obesity due to overeating
d) is due to genomic imprinting
e) all of the above
_____
A probe:
a) carries a light bulb
b) binds with its complementary sequence
c) is single-stranded
d) identifies a match between the probe and RNA (or DNA)
e) all of the above
_____
A Turner’s Syndrome individual has the karyotype:
a) 47XYY
b) 45XO
c) 46XX
d) 47XXY
e) 45YO
_____
Which of the following is NOT a type of polymorphism?
a) RFLP
b) SNP
c) variable number of tandem repeats
d) insertion
e) none of the above
_____
Genetic linkage was first described by:
a) Mendel
b) Morgan
c) Galton
d) Watson
e) Crick
_____
True/False
Familial AD is associated with early onset.
_____
A man with genotype AO at the ABO locus has the blood type (phenotype) A.
_____
XXY males are hypermasculinized and aggressive.
_____
Prader-Willi and Angelman’s Syndromes result from deletions of the same
chromosomal segment.
_____
The best predictor of Down’s syndrome is paternal age.
_____
The frequency of chromosomal disorders at fertilization is about 10%
_____
100% of AD cases are accounted for by APP, presenilin 1, presenelin 2, and ApoE4.
_____
An extra or missing autosome is usually ok.
_____
Fill in the Blank
The technique ____________________ is used to amplify DNA.
If two loci are rarely separated by recombination, then they are ____________________.
The “gold standard” for diagnosing AD is identification ____________________ and
____________________.
The karyotype ____________________ characterizes a normal male.
____________________ is the major disadvantage of population-based association studies.
____________________ is the progressive and irreversible loss of intellectual function.
The process of making double-stranded DNA single-stranded is called ____________________.
*** I have removed the Short/Long Answer portion, in case Dr. Carey decides to use the same
questions, but here are the basics of those questions:

Know how to give the genotypes, phenotypes, and frequencies for a given cross (know how
to do a Punnett square and give results)

What is the meaning of 1p15.33?

Know what PCR, RFLP, and SNP stand for and what they are and what their significance is

Know: Alzheimer’s disease; restriction enzymes and function; electrophoresis; and
polymorphisms