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Download Gene Section JUNB (jun B proto-oncogene) Atlas of Genetics and Cytogenetics
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Atlas of Genetics and Cytogenetics in Oncology and Haematology OPEN ACCESS JOURNAL AT INIST-CNRS Gene Section Mini Review JUNB (jun B proto-oncogene) Fei Chen Health Effects Laboratory Division, NIOSH, 1095 Willowdale Rd, Morgantown, WV 26505, USA (FC) Published in Atlas Database: January 2003 Online updated version: http://AtlasGeneticsOncology.org/Genes/JUNBID178.html DOI: 10.4267/2042/37952 This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 2.0 France Licence. © 2003 Atlas of Genetics and Cytogenetics in Oncology and Haematology Localisation Identity Nuclear. Other names: JUN-B; JUN protooncogene homolog B HGNC (Hugo): JUNB Location: 19p13.2 Function JUNB is a member of JUN family (JUN, JUNB and JUND) that can dimerize with one another, or with members of Fos and ATF families, to form AP-1 transcription factor. Comparing with JUN, the transactivation activity of JUNB is much weaker. Due to the small differences on the amino acid sequences in the basic DNA bindind domain, and leucine zipper domain, JUNB requires multiple AP-1 DNA binding sites for sufficient DNA binding. A number of studies demonstrated that JUNB antagonizes the functions of JUN in cell cycle regulation, proliferation and transformation by competing with JUN to form less efficient transactivating dimers. Thus, JUNB was considered as a tumor suppressor. In gene knockout studies, mice lacking Jun gene die during embryonic day 12.5 and 13.5, whereas embryos lacking JunB die earlier, around day 9.5, owing to vascular defects in the placenta and extraembryonic tissue. Interestingly; gene knock-in experiment indicated that JUNB could partially substitute the activities of JUN in mouse development and cell proliferation. As possible explanation for this is that in presence of JUN, JUNB is a negative regulator for JUN. In contrast, in the absence of JUN, JUNB may substitute JUN and activate AP-1 target genes required for development and cell proliferation. DNA/RNA Description The JUNB gene maps on chromosome 19p13.2 covering 1820 bp. Transcription It contains no confirmed intron. Therefore, no alternative splicing transcripts have been identified. Protein Description JUNB has 347 amino acids with a predicted molecular weight 35,9 kD. Structurally, JUNB is similar to JUN, which contains a JNK docking site, nuclear localization signal, basic domain for DNA binding and a leucine zipper domain for dimerization. However, JUNB does not contain a JUNK phosphorylation site. Thus, the transa-ctivation activity of JUNB is not regulated by JNK. Expression Ubiquitously expressed. Atlas Genet Cytogenet Oncol Haematol. 2003; 7(2) 87 JUNB (jun B proto-oncogene) Chen F Implicated in References Inflammation, cancer Schorpp-Kistner M, Wang ZQ, Angel P, Wagner EF. JunB is essential for mammalian placentation. EMBO J. 1999 Feb 15;18(4):934-48 Oncogenesis Decreased expression of JUNB has been observed in certain human cancer. However, no mutation, rearrangement or amplification of JunB gene has been reported. Passegué E, Jochum W, Behrens A, Ricci R, Wagner EF. JunB can substitute for Jun in mouse development and cell proliferation. Nat Genet. 2002 Feb;30(2):158-66 This article should be referenced as such: Chen F. JUNB (jun B proto-oncogene). Atlas Genet Cytogenet Oncol Haematol. 2003; 7(2):87-88. Atlas Genet Cytogenet Oncol Haematol. 2003; 7(2) 88