Download LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034
M.Sc. DEGREE EXAMINATION – BIOMEDICAL INSTRUMENTATION
FOURTH SEMESTER – APRIL 2014
BI 4808 - BIOMEDICAL INFORMATICS
Date : 29/03/2014
Time : 01:00-04:00
Dept. No.
Answer all of the following
Max. : 100 Marks
Section - A
10 x 2 = 20
1.Give note on MSA editors and formatters.
2.Comment on FASTA.
3.What are profiles?
4.What is eMOTIF analysis?
5.Define database similarity search.
6.Write short note on connection table.
7.What is SMILES format for Isopropyl alcohol and benzene?
8.Differentiate e- value and p-value.
9.Expand OMIM and HCGD
10.Name the two strategies for in-silico drug design.
Answer any four of the following.
Section – B
4 x10 = 40
11.Discuss about the features available in NCBI .
12.Write detailed notes on tools available for structural analysis and prediction of proteins.
13.Explain the components of GenScan, Uniprot of PDB servers in detail.
14.Elaborate on various phases of clinical trials in drug discovery.
15.Describe the Needleman and Wunsch and Smith - Waterman algorithm.
16.Justify the role of Telehealth-Information in patient care and monitoring system.
Answer any two of the following.
Section - C
2 x 20 = 40
17.What do you understand by health informatics and its various aspects?
18.Write in detail objectives and the strategies involved in molecular approach to drug discovery.
19.Write notes on:
a. PIR-PRED
b. Digital libraries
c. Rasmol
d. Clustal W
20.Elaborate on clinical genetic databases and databases of human mutations .
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