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Tissues and Organs Comprising the Immune Response System Where components of the immune response originate, differentiate, meet, interact, and function Folder Title: Tiss&Org Updated: November 10, 2015 APC and T-Cells Marcophage and T-Cell Kissing Macrophage to T-Cell Interaction Helper T-cell B-Cell Interaction CD4 co-receptor B-Cell Activation See figure 2-7, Kuby, 4th Ed., p. 36 B-Cell: Small, Blast, and Plasma See Figure 2-7, Kuby 4th Ed. p. 36 Where do these cells originate? Where do they go to interact with each other? Where do they carry out their functions? Related to Figure 2-13, Kuby, 4th Edition, p. 47 Primary and Secondary Lymphoid Animations Produced for Kuby Immunology Online Link http://bcs.whfreeman.com/immunology6e/ (In Class Do animations from the Book CD) Chapter 2 Animation. Cells and Organs Please put away all notes and any devices except for your Turning Point NXT Transmitter. No papers or computers on your desk please. No communication between or among students. Exactly* what kind of Cell is the one attached to the B-Cell? *(“exactly” means not just its general type of cell, but specifically what type of cell it is based on what this figure shows that the cell is doing) Rank 1 2 3 4 5 6 Responses 100% 90% 80% 70% 60% 50% 40% 30% 20% 10% 0% 0% 0% 0% 0% 0% 1 2 3 4 5 6 0% What is the blue thing that looks like an alligator clip on the cell attached to the macrophage or to the B-cell? Rank 1 2 3 4 5 6 Responses 100% 90% 80% 70% 60% Blue thing 50% 40% 30% 20% 10% 0% 0% 0% 0% 0% 0% 1 2 3 4 5 6 0% What is the purple thing that looks like a hook on the cell attached to the macrophage or to the B-cell? Rank 1 2 3 4 5 6 Responses 100% 90% 80% 70% 60% 50% 40% 30% 20% 10% 0% 0% 0% 0% 0% 0% 4 5 6 0% Purple Thing 1 2 3 Thymus Photo Thymus Cartoon Diagrammatic Cross Section of Thymus. Figure 2-14, Kuby, 4th Edition, p. 48 ThymusCross CD4 and CD8 in Thymus MALT and M-Cells See Figure 2-22, Kuby 4th Ed. p. 56 MALT and IgA See Figure 2-22 Kuby, 4th Ed. p. 56 CD Antigen Table CDMarks CD Antigens Color Coded Animations Produced for Kuby Immunology http://bcs.whfreeman.com/immunology6e/ Chapter 11 Animation. Signal Transduction CD Antigen List: Pages A1 to A26: 339 Entries, 2007 Edition of Kuby How to Understand CD Antigens: 5 Persons at a University Person 1: Person 2: Person 3: Person 4: Person 5: 5 ft 5”, 160 lbs bespectacled old geezer 5 ft 11”, 280 lbs, 22-year old guy, all muscle 5 ft 5”, 135 lbs, 20-year-old woman 7 ft 1” , 200 lbs, 22 year-old guy 5 ft 8”, 150 lbs, 22 year-old guy Person 1: Person 2: Person 3: Person 4: Person 5: 5 ft 5”, 160 lbs bespectacled old geezer 5 ft 11”, 280 lbs, 22-year old guy, all muscle 5 ft 5”, 135 lbs, 20-year-old woman 7 ft 1” , 200 lbs, 22 year-old guy 5 ft 8”, 150 lbs, 22 year-old guy Which Person: A. Is a varsity basketball player? B. Plays on the women’s field-hockey team? C. Is a boring old professor? D. Is a varsity football player for SU? E. Is a men’s cross-country runner? 1C; 2D; 3B; 4A; 5E Signal, Receptors, and co-receptor Pairs Secrets of Signaling 1. How Do You Knock on a Door? Why that way? 2. Why does the phone “ring” more than once? 3. Why can the police officer directing traffic blow his whistle only once? 4. Why does your computer say “Are You Sure You Want to Delete File XYZ?” 5. When the class was directed to do “Bunny Ears” behind the person next to them, only a few persons responded. Why was that? 6. A different set of persons responded when asked to raise their right hand. Why was that? 7. No one responded when the class was asked to stand up. Why? Secrets of Signaling (2) 8. Only the guys in the front of the room responded when I invited the class to do what all classes would love to do to a pain-in-the neck Prof. Why was that? 9. I asked the class in plain English to raise both hands but no one complied. Why is that? What did that illustrate about properties of signaling. 10. I gave the answer to the coming quiz question to the entire class in plain English but no one heard the answer even though I said it clearly and loudly. Why not? What did that illustrate about cell signaling? 11. Why does the T-Helper Cell physically attach itself to the macrophage? What is the advantage of that? Costimulatory signals: B7 – CD28 To Here: Nov. 4, 2014; 2nd Exam Nov. 6th Costimulatory Signals: T-Cell to MPh Cancer Eluding Costimulatory Signal CD’s on B, T, and NK Cells Surface Determinants on B-Cells: Immunoglobulins B7 Surface Determinants on T-Lymphocytes: Note: CD4 TH CD8 TC CD28 and CD3 Both. NK Determinants: CD56 CD16 CD8 CD Markers in Leukemia Diagnosis Staging Prognosis Treatment (“ALL” = Acute Lymphocytic Leukemia) T-Cell ALL Markers Kuby, 5th Edition p. 157 Pre-B-Cell ALL Markers (“ALL” = Acute Lymphocytic Leukemia) Kuby, 5th Edition p. 157 (“CLL” = Chronic Lymphocytic Leukemia) B-Cell CLL Markers Kuby, 5th Edition p. 157 Leukocyte Recirculation How Do Circulating Hematopoietic Cells “Know” Where They Are? How Do they Stick? How Do they Move? Lymphocyte Recirculation Leucocytes in Capillaries Cartoon Leucocytes in Capillaries Photo Extravasation (Getting out of the Blood Stream) of Naïve T-Cell into Lymph Node CAM = Cell Adhesion Molecule Adhesion: Leucocytes to Endothelium (Non-inflamed Endothelium) CAM = Cell Adhesion Molecules Membrane of Circulating Leucocytes General Structures of Cell Adhesion Molecules (CAMs) Kuby, 3rd Edition Figure 15-2a CAMStruct Endothelial Cells Lining Capillaries CAMinCap Adhesion in Capilaries (Inflamed Endothelium) Neutrophils trails guide virus-specific CD8+ T cell migration. Chemokine from Uropod of Neutrophils Kihong Lim et al. Science 2015;349:aaa4352 Published by AAAS Neutrophils trails guide virus-specific CD8+ T cell migration. (CXCL12 is a chemokine: chemical agent attracting cell movement) Virus-specific Cytotoxic T-Cell Blebs containing CXCL12 from Uropod (Trailing membrane region) of Neutrophil “Bread-crumb” trail Kihong Lim et al. Science 2015;349:aaa4352 Cytotoxic T-Cell migration through trachea to virus-infected cells Published by AAAS Please put away all notes and any devices except for your Turning Point NXT Transmitter. No papers or computers on your desk please. No communication between or among students. When a leukocyte traveling in the blood-stream enter the capillary circulation in a tissue that is under bacterial attack, which of the following happen? The system should accept four correct answers 1. 2. 3. 4. 5. 6. 7. 8. The leucocyte immediately degranulates The leukocyte goes into cell division The leukocycte binds to the capillary endothelial cells (High endothelial venules) The leukocyte rolls along the endothelial lining. The leukocyte elicits membrane signals from the endothelial cells that bind the leukocyte tightly. The endothelial cells then enter apoptosis The leukocyte extravastates The leukocyte makes antibodies Response Counter 0% 0% 1. 2. 0% 0% 0% 0% 0% 0% 3. 4. 5. 6. 7. 8. Which of the following are Primary Lymphoid Organs? (Two responses should be accepted by the system) 1. 2. 3. 4. 5. 6. 7. 8. 9. Mucosal associated lymphoid tissue (MALT) Tonsils Adenoids Thymus Thyroid Bone marrow Cervical lymph nodes Spleen Lumbar lymph nodes Response Counter 0% 0% 0% 0% 0% 0% 0% 0% 0% 1. 2. 3. 4. 5. 6. 7. 8. 9. If a red blood cell is an erythrocyte, what is a T-cell? _________________ cyte Rank 1 2 3 4 5 6 Responses 0% 0% 1 2 0% 0% 3 4 0% 0% 5 6 Slides Beyond this Point Not included in BIO447, Fall, 2014 On a scale from –2 to +2 (Use #1 on Key-pad) -2 = I’m lost; 5 (Use #2 on Key-pad) -1 = I’m having a hard time, but I follow some of it. (Use #3 on Key-pad) 0 = I’m doing OK. I uderstand most of it. I can figure the rest out later. (Use #4 on Key-pad) +1 = I’m following OK. No problem (Use #5 on Key-Pad) +2 = This is pretty straight-forward, Please move on. 4 3 2 1 Duration: 0 Seconds How Well Are You Following What is Being Presented so Far in theCourse? (This will be set to anonymous so you will not be identified and your response will not be graded) 1. 2. 3. 4. 5. I’m totally lost. I’m having hard time, but I follow some of it. I’m OK. I can figure most of it out later. I’m following very well. There is no problem with the level of the course. This isn’t pitched at a level appropriate for an upper division undergraduate course. Please move to a higher level of challenge. 0% 0% 0% 0% Response Counter 1. 2. 3. 4. 0% 5. Animations Produced for Kuby Immunology http://bcs.whfreeman.com/immunology6e/ Or search “Kuby Immunology”, Click on “Kuby Immunology 6e” , go to Student Resources Chapter 2: Cells Cell Death (Also chapter 10) Chapter 11: Signal Transduction Chapter 13: Leucocyte Extravasation Actin Cytoskeleton Linkage to Collagen Extra-cellular Matrix Figure 19-14 ECB 1998, p. 603 Collagen Fibronectin Integrin Plasma Membrane Actin Microfilament MFtoECM Tissue-target Cells in Red Leucocyte CAM in Blue CAMFamly On Endothelial Cells On Neutrophils On Mucosal Epithelium On Leucocytes On Endothelial Cells On Leucocytes CamFamly On Endothelial Cells Families of Cell Adhesion Molecules Kuby, 3rd Ed. Figure 15-2b Animations Produced for Kuby Immunology OnLine Link http://bcs.whfreeman.com/immunology6e/ In Class Use Book CD: Chapter 2: Cells of the Immune-system (Static) Cell Death : (Animated) Chapter 11: Signal Transduction (Animated) Chapter 4 : Immunoglobulins (Static) Chapter 13 Animation. Leukocyte Extravasation (Animated) T-Cells are lymphocytes that are “educated” in the 1. Tonsils 2. Toe-nails 3. Teeth 4. Thyroid 5. Thymus 6. Testicles 7. Thoracic Duct 8. None of the above Response Counter 0% 0% 1. 2. 0% 0% 0% 0% 0% 0% 3. 4. 5. 6. 7. 8.