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BCH 450 Specialized Tissues(Nervous Tissue) Dr. Samina Hyder Haq Dept of Biochemistry King saud university Nervous Tissue is one of 4 major Class of Tissue CNS: Consist of Brain, spinal cord PNS: Peripheral nervous system consist of cranial and spinal nerves contain both motor and sensory neurons. It connect CNS to muscles, glands and all sensory receptors Major Structures of the Nervous System Brain, cranial nerves, spinal cord, spinal nerves, ganglia, enteric plexuses and sensory receptors 3 Organization of the Nervous System CNS is brain and spinal cord PNS is everything else 4 Subdivision of PNS SNS:Somatic(Voluntary) system Neurons from cutaneus regions Motor neurons to skeleta system ANS: autonomic(Involuntary) Nervous system Sensory Neurons from visceral organs Motor Neurons to smooth and Cardiac muscles. Sympathetic( speeds up heart rate) Parasympathetic (slows down heart rate) ENS: Enteric nervous system(Involuntry neurons to GI Parts of Human Brain The brain of all vertebrates develops from three swellings at the anterior end of the neural canal of the embryo. From front to back these develop into the forebrain (also known as the prosencephalon) midbrain (mesencephalon) hindbrain (rhombencephalon) The brain receives nerve impulses from the spinal cord and 12 pairs of cranial nerves Forebrain Cerebral Hemisphere Largest part of the human brain. Controls thinking, speech, vision, hearing and all voluntary acts Mid Brain mesencephalon occupies only a small region in humans (it is relatively much larger in "lower" vertebrates Controls balance and muscle coordination Hind Brain The main structures of the hindbrain are medulla oblongata Controls all involuntary acts (breathing, heart beat, digestion, reflexes) pons (The pons seems to serve as a relay station carrying signals from various parts of the cerebral cortex to the cerebellum cerebellum Its most clearly-understood function is to coordinate body movements. So the cerebellum appears to be a center for learning motor skills. Parts of Brain Grey matter and white matter Both the spinal cord and the brain consist of white matter = bundles of axons each coated with a sheath of myelin gray matter = masses of the cell bodies and dendrites — each covered with synapses The Meninges Both the spinal cord and brain are covered in three continuous sheets of connective tissue, the meninges. From outside in, these are the dura mater — pressed against the bony surface of the interior of the vertebrae and the cranium the arachnoid the pia mater The region between the arachnoid and pia mater is filled with cerebrospinal fluid (CSF). The fluid that leaves the capillaries in the brain contains far less protein than "normal" because of the blood-brain barrier, a system of tight junctions between the endothelial cells of the capillaries. This barrier creates problems in medicine as it prevents many therapeutic drugs from reaching the brain. Nervous system Cells of the Nervous system Neurons Neuroglial cells have 4 cell types in CNS Atrocytes.oligodentrocytes,microglia and ependymal 2. 2 cell types in PNS that is Schwann and satellite cells 1. Neurons Functional unit of Nervous system Have capacity to produce Action potential Cell Body containing large Nucleus and Nuclelous, neurofilament and neurotubules. Contain RER and free ribosomes called Nissl bodies. Types of neurons Functional Classification: Sensory. Motor and unipolar inter-neurons Bipolar Structural classification: Multipolar Astrocytes Star shaped cells Form Blood brain Barrier by covering blood capillaries Metabolize neurotransmitter Regulates K+ balance Provide structural support.