* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Download "Multiscale Patient-Specific Systems Biology" Scott L. Diamond, PhD
Survey
Document related concepts
Homeostasis wikipedia , lookup
History of biology wikipedia , lookup
Developmental biology wikipedia , lookup
Synthetic biology wikipedia , lookup
Personalized medicine wikipedia , lookup
Neurogenetics wikipedia , lookup
Gene regulatory network wikipedia , lookup
Biotechnology wikipedia , lookup
History of biotechnology wikipedia , lookup
Microbial cooperation wikipedia , lookup
Organ-on-a-chip wikipedia , lookup
Biomolecular engineering wikipedia , lookup
Transcript
"Multiscale Patient-Specific Systems Biology" Scott L. Diamond, PhD Professor and Chair, Department of Chemical and Biomolecular Engineering Institute for Medicine and Engineering University of Pennsylvania Predicting tissue function based upon an individual’s unique cells requires a multiscale Systems Biology approach to understand the coupling of intracellular signaling with spatiotemporal gradients of extracellular biochemicals. In the cardiovasculature, extracellular species are also controlled by convective-diffusive transport. Using high throughput experimentation, we obtained a large set of platelet responses to combinatorial activators in order to train a neural network (NN) model of platelet activation for several individuals. Each NN model was then embedded into a kinetic Monte Carlo/finite element/lattice Boltzmann simulation of stochastic platelet deposition under flow. In silico representations of an individual’s platelet phenotype allowed prediction of blood function under flow, essential to prioritizing patient-specific cardiovascular risk and drug response or to identify unsuspected gene mutations. Chatterjee MS, et al. Nature Biotechnology 28:727 (2010) Flamm MH, et al. Blood 120:190 (2012)