Download Platelet Pool - Leucocyte Depleted

NATIONAL
111S00201
BLOOD COMPONENT DATASHEET
PLATELET POOL
LEUCOCYTE DEPLETED
COMPONENT DESCRIPTION
A pool of platelets derived from the buffy coats of four whole blood donations and
6
containing less than 5 x 10 leucocytes per pool.
QUALITY SPECIFICATIONS
Volume:
Leucocyte Count:
Platelet Count:
CMV Status:
High titre anti-A or B:
Anticoagulant:
pH at out date:
Fibrinogen:
Factor VIIIc:
Supernatant Hb:
Haematocrit:
200 - 350 mls
<5 x 106 per pool
≥ 2.4 x 1011 per pool
On demand
Indicated on label if present
CPD
6.4 – 7.4 (day 5)
N/A
N/A
N/A
N/A
USES
To provide platelet replacement where quantitative or qualitative deficiency of
platelets is causing or may cause a significant haemostatic problem.
DOSAGE AND ADMINISTRATION
Dosage
One unit of platelet pool-leucocyte depleted will result in adequate clinical response
in most instances. In some cases more than one unit may be necessary. In patients
with increased platelet consumption or destruction the dose is determined by clinical
response.
Prepared by: Susanta Ghosh
Authorised by: Peter Flanagan
QA Approved by: Nick Smith
Effective Date: 11/01/02
Copy No:
Page 1 of 3
File Name: 111S00201
Previous Name: N/A
NATIONAL
111S00201
Administration
The ABO group of the platelet concentrate should preferably be compatible with that
of the patient but this is not essential. Platelet concentrate contains a few red cells
and when prepared from Rh(D) positive donors may result in the production of antiRh(D) antibodies in Rh(D) negative patients.
Where the product is labelled as Rh(D) Positive and given to an Rh(D) negative
female of reproductive years or younger, consideration should be given to
prophylaxis with anti-D.
Platelets must be transfused intravenously through an infusion set with an in-line
170-200 micron filter. The infusion should generally be completed within 30 minutes.
It is a legal requirement that all details of blood component infusion are documented
in the patient’s case notes (eg, date and time of issue, product number, ordering
medical officer, given by, checked by, time started).
CONTRAINDICATIONS, WARNINGS, ADVERSE REACTIONS
Contraindications
Platelet transfusions have been implicated in severe adverse reactions in patients
with thrombotic thrombocytopenic purpura and heparin induced thrombocytopenia.
Platelet concentrate may cause adverse reactions particularly to patients with history
of non-haemolytic transfusion reactions though this type of reaction is less common
with leucodepleted components.
Recipients with severe cellular immune-deficiency and those receiving transfusions
from related donors should be transfused with irradiated platelets.
Warning
Acute transfusion reactions may occur if incompatible, wrongly stored or bacterially
contaminated platelets are transfused.
Non-haemolytic transfusion reactions can present as urticaria, fever and rarely as
anaphylaxis. Symptoms include chills, rigors, fever, chest tightness, hypotension.
The transfusion should be stopped immediately and the cause investigated. The
implicated component should be returned to the blood bank.
Prepared by: Susanta Ghosh
Authorised by: Peter Flanagan
QA Approved by: Nick Smith
Effective Date: 11/01/02
Copy No:
Page 2 of 3
File Name: 111S00201
Previous Name: N/A
NATIONAL
111S00201
Adverse Reactions
Immune: Immunisation to leucocyte antigens and platelet antigens can make the
patient refractory to subsequent platelet transfusion, though this complication is less
frequent than with non-leucodepleted component. Small numbers of red cells
present in platelet concentrate may occasionally lead to immunisation to red cell
antigens.
Transfusion related lung injury might occur if antibodies to recipient’s granulocytes
are present in donor plasma.
Transfusion of non-irradiated products can cause graft versus host disease in
patients with severe cellular immune deficiency or in those receiving transfusion from
genetically related donors.
Haemodynamic:
overload.
Transfusion of excessive volumes may lead to circulatory
Infective: Every care is taken in donor selection and in blood collection, processing
and storage to reduce the risk of infection but there is a small but definite risk of
transmitting bacterial, viral and other infections. Platelet pools usually involve
exposure to several donors and this may increase the risk of infection.
Risk of bacterial contamination is higher with platelets as they are stored at room
temperature. Reaction to bacterially contaminated platelets usually develops within
minutes and consists of chills, rigors, fever, nausea, vomiting, diarrhea, abdominal
and muscle pain, hypotension, haemoglobinaemia and disseminated intravascular
coagulation.
Recipients showing signs and symptoms consistent with septic reaction should be
treated for septic shock before laboratory results are available. Haemostatic failure
may develop in these recipients and they may require appropriate support.
STORAGE AND PRECAUTIONS
Store at 20 °C to 24 °C with agitation. If platelets have been pooled use within 6
hours or within the expiry time stated on the bag. Do not use if the material is clotted
or the bag is damaged. Discard all used or partially used bags. All unused bags
should be returned to the Blood Bank. Avoid skin contact with this preparation.
FURTHER INFORMATION
Each unit conforms to the NZBS specification for donor selection and collection
procedure. Each unit has tested negative for HBsAg, Anti-HIV-I and -II, anti-HCV
and syphilis. This component has also tested negative for HCV and HIV viral RNA
using NAT method.
Prepared by: Susanta Ghosh
Authorised by: Peter Flanagan
QA Approved by: Nick Smith
Effective Date: 11/01/02
Copy No:
Page 3 of 3
File Name: 111S00201
Previous Name: N/A