Download Bioengineering and Applied Life Sciences

Bioengineering and Applied Life Sciences
Fabrication of Open Pores Biodegradable Nano-Fibrillar /Micro-Fibrillar
Devices for Controlled Drug Delivery
Background:
Drug delivery systems can employ polymeric carriers for
enhancing controlled delivery of a given pharmaceutical
compound. Current methodologies employ the usage of
non-elongated polymeric particles for such delivery.
Such particles are subject to the frequent complication
where individual fibers puncture cell walls at the delivery
target area. The number of products on the market
based on polymeric micro or nano-particles is limited.
This is due to the cititoxocity of polymers and the lack
of a suitable large-scale production method.
Description of Invention:
This invention relates to the provision of elongated polymeric fibers as delivery
vehicles. The technologies consists of two steps – creation and isolation of open
pore nano and micro-fibrils of biodegradable PLA, PGA PLGA and other polymers of
interest, and second the loading of the porous nano and micro-fibrils with drugcontaining lipids or biological active substances.
Advantages:
The novel structure renders superior delivery performance because the aspect ratio of
the elongated fiber prevents any puncturing of cells in the target area. The PLA
material used is well documented with respect to its applicability for such purposes.
The manufacture excludes the use of toxic solvents or similar reagents enabling the
use of bioactive additives in the devices. The loading of fibrils with the drugcontaining lipid is more effective due to the large number of deep cavities and pores.
Business Opportunity:
Partners are sought to commercialize the technology.
Patent Status:
A U. S. patent application is pending.
Technology Contact
Professor Jing Wu
Chemical Engineering Department
New Jersey Institute of Technology
Newark, NJ 07102
(973)-596-7064 [email protected]
Business Contact
Judith Sheft, Asst Vice President Technology
Development
University Heights., GITC 3404
New Jersey Institute of Technology
Newark, NJ 07102
(973) 596-5825 [email protected]
New Jersey Institute of Technology