Download Orange2 Thesis Poster - Rachel Starr - Chemistry

Method Development for Synthesis of the
Allal-Derived 2-Amino Free Reducing Sugar
Rachel Starr
Wednesday, 4/20
2:00-2:50 pm
Altschul 805
Synthesizing amino sugar libraries for practical applications is a challenge in organic synthesis. Amino
sugars are biologically important molecules that differ from normal other sugars by an amino
substitution. They drive essential biological functions in bacterial, plant, and mammalian cells.
Modifying these sugars changes the properties of the molecules to which they are attached, an
approach especially relevant in drug discovery. Glycodiversification is the synthesis of analogues of
naturally occurring carbohydrates. By Through optimizing glycodiversification, libraries of amino
sugars can be synthesized and tested on drug scaffolds for to optimize drug properties such as
potency and toxicity. This thesis work focuses on amidoglycosylation, deprotection, and
neoglycosylation reactions, toward the goal of glycodiversification.