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CHM 708
Medicinal Chemistry
DNA
Stereochemistry
Definitions
Autoreceptor
A receptor that regulates the synthesis and/or
release of its own endogenous ligand
Affinity
The ability of a drug to bind to the receptor
Efficacy
The relative intensity of the response produced
by a drug binding to a given number of receptors
with the same affinity
Potency
The dose of drug required to produce a specific
effect.
ED50
The median effective dose; the dose required to
produce half the maximum effect, or a given effect
in half the experimental animals or organisms.
EC50
The median effective concentration; used instead
of ED50 for in vitro experiments
Definitions (contd.)
IC50
The median inhibitory concentration; defined the
same way as EC50, but for antagonists
TD50
The median toxic dose; the dose that produces a
given toxic response in half the experimental
animals or organisms.
LD50
The median lethal dose
Therapeutic
Index
The ratio TD50 / ED50
Tolerance
The decrease of the intensity of the response to
a given dose over a period of time.
Inverse agonist
A drug that binds to the same site as an agonist,
but produces the opposite effect.