* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Download 200-Level Biochemistry
Survey
Document related concepts
Artificial gene synthesis wikipedia , lookup
Protein structure prediction wikipedia , lookup
History of genetic engineering wikipedia , lookup
Synthetic biology wikipedia , lookup
Biotechnology wikipedia , lookup
Endogenous retrovirus wikipedia , lookup
Protein adsorption wikipedia , lookup
Western blot wikipedia , lookup
Two-hybrid screening wikipedia , lookup
Interactome wikipedia , lookup
Bioinformatics wikipedia , lookup
Metabolic network modelling wikipedia , lookup
Chemical biology wikipedia , lookup
History of biotechnology wikipedia , lookup
Gene Disease Database wikipedia , lookup
Transcript
200-Level Biochemistry NEW ZEALAND For a BIOCHEMISTRY major in a BSc degree you need to take three 200-level BIOC papers, BIOC 221, BIOC 222 and BIOC 223. For a BIOCHEMISTRY minor you need to take two of BIOC 221, BIOC 222 and BIOC 223. These Biochemistry 200-level papers can be included in other majors in a BSc, BBiomedSc, BAppSc, BCApSc, or crosscredited to other degrees (e.g. Arts, Commerce or Law). Below you will find a brief description of each of the three 200-level BIOC papers, followed by the paper prescriptions and some information on the pre-requisites and recommended combinations of papers. Additional information relating to timetabling, paper restrictions and major subject requirements can be found in your Guide to Enrolment, or visit the following website: www.otago.ac.nz/subjects/bioc.html#major For further information contact Tony Zaharic in the BIOC 192 office, or see http://biochem.otago.ac.nz/courses/index.html (for information on courses and papers) http://biochem.otago.ac.nz/courses/undergrad.html (for information on pathways of study) BIOC 221 Molecular Biology First Semester Molecular biology is the study of biology at a molecular level and has revolutionized our understanding of how cells and organisms function. In this paper you will learn how information is stored in DNA, how it is retrieved and how it can be manipulated. Discoveries in molecular biology are profoundly changing the world we live in - from the sequencing of the human genome, which is leading to new ways to diagnose and treat disease, to genetically modified microbes and plants. BIOC 221 is a required first semester paper if you are thinking of majoring in Biochemistry, and is highly recommended for Genetics. In fact, there is probably no field of biology that does not utilise the knowledge or techniques of molecular biology, and this paper is therefore useful for students majoring in any of the life sciences. In BIOC 221 we will look at the genomes of bacteria, fungi, plants and animals, and discuss how genetic information is encoded, replicated, packaged, and can be analysed using the tools of molecular biology. Next, we focus on the structure and regulation of individual genes and follow the flow of information into protein synthesis. Throughout the course, emphasis will be placed on genetic engineering and how we can identify and manipulate genes using new technologies developed for the genome projects. The project-based, modular laboratory course will reinforce the lecture material and provide hands on experience in molecular biology research. BIOC 222 Proteins and Biotechnology Second Semester Biotechnology is seen as a new industrial revolution, with the smoke stacks, factories and mines of the 19th Century being replaced with a knowledge-based industry of biochemical processes and information relating to genes, proteins and metabolism. In this course we will introduce you to the fundamental properties of proteins, with a focus on how ‘sequence determines structure’ and ‘structure determines function’. We will also explore the mechanisms by which cells control and modify protein function. We will examine how a protein’s lifetime is regulated and how a protein’s activity can be stimulated or repressed by different modifications. The basic properties of enzymes will also be introduced and we will study specific examples of catalysis. How proteins and enzymes can be engineered, and the industrial application of enzymes and their use as drug targets will also be studied. Common techniques used to study proteins will be reviewed. The course will conclude by bringing together this knowledge using examples of specific new biotechnological processes and how these will influence medicine, agriculture and biodiversity. The lecture course is complemented by a practical course that will provide experience in the experimental techniques used to purify and characterize proteins. You will apply experimental techniques, research the scientific literature and search databases to fully characterize isolated proteins. BIOC 223 Cellular Biochemistry and Metabolism Second Semester This paper focuses on the way that living systems obtain their energy and how this energy is captured and used to maintain the cell, and for growth. We examine how different fuels are utilised, how core metabolic molecules are produced and the way in which nitrogen is metabolised. Finally, we look at signalling systems that integrate and control all of these different processes. The topics covered include aerobic and anaerobic energy metabolism; metabolism of fasting and fed states (particularly in humans); carbon fixation in photosynthesis including the assimilation of the sugars produced in this process; how nitrogen is acquired, used, and disposed of; and the role of hormones such as insulin, glucagon, cortisol and adrenaline in human metabolism. We will also discuss the metabolic basis of a number of diseases including diabetes, metabolic syndrome, and the effects of trauma. The lecture course is integrated with a series of three laboratory blocks that provide an experimental insight into the lecture material, including the role of blood metabolites during exercise and disease, and the biochemical role of some sports drinks, and nitrogen metabolism. The laboratory course involves considerable experimental work and will give you practical experience of in acquiring and analysing biochemical information. The following information was taken from the 2010 Guide to Enrolment. BIOC 221 Molecular Biology (first semester) 18 points From gene to protein. How genetic information is stored and determines biological function. Principles and applications of genetic engineering. Impact of molecular biology on health, agriculture and New Zealand society. Prerequisites: CELS 191 & CHEM 191 & 36 further points Recommended preparation: BIOC 192 Recommended concurrent study: BIOC 222 GENE 221 Proteins and Biotechnology (second semester) 18 points Proteins are drivers of all life processes. The diversity of protein structure and function, and how the shape of proteins determines their function. How biotechnology solves medical and industrial problems. Prerequisites: BIOC 192 & CELS 191 & CHEM 191 & 18 further points Recommended preparation: BIOC 221, GENE 221 Recommended concurrent study: BIOC 223 BIOC 223 Cellular Biochemistry and Metabolism (second semester) 18 points Metabolism provides the fuels and molecules for life. How metabolic processes are regulated and coordinated in animals and plants. Human disease states that arise from metabolic imbalances. Prerequisites: BIOC 192 & CELS 191 & CHEM 191 & 18 further points Recommended preparation: BIOC 221 Recommended concurrent study: BIOC 222