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Download PATHOGEN SAFETY DATA SHEET Herpes Simplex Virus
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Office of Research Compliance PATHOGEN SAFETY DATA SHEET Herpes Simplex Virus CHARACTERISTICS Morphology Growth Conditions HSV-1 and HSV-2 are members of the Herpesviridea family. Are double stranded DNA viruses enclosed within an icosahedral capsid. Cell Culture HEALTH HAZARDS Host Range Modes of Transmission Signs and Symptoms Humans Direct contact with infected secretions or mucous membranes or skins with lesions. Cold sores: Mainly caused by HSV-1. Gingivostomatitis, fever, sore throat, mucosal edema, and painful lesions Genital herpes: Sexually transmitted disease mainly caused by HSV-2. Bilateral, painful, and extensive genital ulcers, which heal without scarring within 12 days. Infectious Dose Incubation Period Unknown. 1 to 26 days. MEDICAL PRECAUTIONS/TREATMENT Prophylaxis Vaccines None None Treatment Surveillance MSU Requirements Antiviral drugs like acyclovir, foscarnet valacyclovir, famciclovir, and penciclovir. Monitor for symptoms. Report any exposures. LABORATORY HAZARDS Laboratory Acquired Infections (LAIs) None. Sources Virus is shed from saliva, cervix, and urethra. CONTAINMENT REQUIREMENTS BSL2 For all procedures involving known or potentially infected cultures. ABSL2 For all procedures utilizing infected animals SPILL PROCEDURES Small Notify others working in the lab. Remove and don new PPE. Cover area of the spill with absorbent material and add 10 % Bleach. Allow 30 minutes hour of contact time. After 30 minutes and then cleanup and dispose of materials. Large For assistance, contact MSU's Biosafety Officer (406994-6998) or Safety and Risk Management (406-9942711). EXPOSURE PROCEDURES Mucous membrane Other Exposures Reporting Medical Follow-up VIABILITY Flush eyes, mouth or nose for 5 minutes at eyewash station. Wash area with soap and water for 5 minutes. Immediately report incident to supervisor, complete a first report of injury report, and submit to Safety and Risk Management. During business hours: Montana Occupational Health 2075 Charlotte St. Suite 3 Bozeman, MT After business hours: Bozeman Deaconess Hospital Emergency Room 915 Highland Blvd Bozeman, MT Disinfection Susceptible to 10 % Bleach, and 70 % ethanol. Inactivation Inactivated by dry heat (1 hour at 160-170oC). SUPPLEMENTAL REFERENCES Survival Outside Host Unknown. Canadian MSDS: PERSONAL PROTECTIVE EQUIPMENT (PPE) BMBL:5th Edition CDC http://www.phac-aspc.gc.ca/lab-bio/res/psdsftss/index-eng.php http://www.cdc.gov/biosafety/publications/bmbl5/BM BL.pdf http://www.cdc.gov/std/herpes/stdfact-herpes.htm Minimum PPE Requirements Additional Precautions At minimum, gloves, closed toed shoes, lab coat, and appropriate face and eye protection prior to working with Herpes Simplex Virus. Additional PPE may be required depending on lab specific SOPs. None.