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Office of Research Compliance PATHOGEN SAFETY DATA SHEET Streptococcus agalactiae CHARACTERISTICS Morphology Growth Conditions Gram-positive facultative anaerobe that is usually found in pairs or chains. Can be placed in various growth media and incubated at 37oC. HEALTH HAZARDS Host Range Modes of Transmission Signs and Symptoms Infectious Dose Incubation Period: Humans and Animals. Hand-to-mouth and aerosol transmission is common. 10-30% of women are positive in their genital tracts although the bacterium is normally a resident of the gastrointestinal tract. Shaking chills, chest pain, dyspnea, fever, productive cough, and sinusitis. Can cause middle ear infections. Can progress to pneumonia, bacteremia, meningitis. Unknown For early onset disease, less than 7 days. For late onset disease, the incubation period is unknown. MEDICAL PRECAUTIONS/TREATMENT Prophylaxis Vaccines Penicillin or ampicillin have been shown to reduce transmission and morbidity to the neonate None. Treatment Surveillance MSU Requirements Antibiotic treatment. Monitor for symptoms of infection. Report any exposures LABORATORY HAZARDS Laboratory Acquired Infections (LAIs) Sources 78 documented cases since 1999 Sputum, blood, respiratory secretions, throat swabs, parenteral inoculation. SUPPLEMENTAL REFERENCES Canadian MSDS: BMBL:5th Edition CDC http://www.phac-aspc.gc.ca/lab-bio/res/psdsftss/index-eng.php http://www.cdc.gov/biosafety/publications/bmbl5/BM BL.pdf http://www.cdc.gov/groupbstrep/clinicians/clinicaloverview.html CONTAINMENT REQUIREMENTS BSL2 For all procedures involving known or potentially infected cultures. ABSL2 For all procedures utilizing infected animals SPILL PROCEDURES Small Notify others working in the lab. Remove and don new PPE. Cover area of the spill with absorbent material and add 10 % Bleach. Allow 30 minutes hour of contact time. After 30 minutes and then cleanup and dispose of materials. Large For assistance, contact MSU's Biosafety Officer (406994-6998) or Safety and Risk Management (406-9942711). EXPOSURE PROCEDURES Mucous membrane Other Exposures Reporting Medical Follow-up VIABILITY Disinfection Inactivation Survival Outside Host Flush eyes, mouth or nose for 5 minutes at eyewash station. Wash area with soap and water for 5 minutes. Immediately report incident to supervisor, complete a first report of injury report, and submit to Safety and Risk Management. During business hours: Montana Occupational Health 2075 Charlotte St. Suite 3 Bozeman, MT After business hours: Bozeman Deaconess Hospital Emergency Room 915 Highland Blvd Bozeman, MT Susceptible to 10 % Bleach, 70 % ethanol, and 2 % gluteraldehyde. Inactivated by moist heat (15 minutes at 121oC) and dry heat (1 hour at 160-170oC). Has been found to survive months in dry dust in buildings. It can survive in milk at -20oC for 4 weeks and in fish tissues at 700C for at least 9 months. PERSONAL PROTECTIVE EQUIPMENT (PPE) Minimum PPE Requirements Additional Precautions At minimum, gloves, closed toed shoes, lab coat, and appropriate face and eye protection prior to working with S. agalactiae. Additional PPE may be required depending on lab specific SOPs. All procedures that may produce aerosols, or involve high concentrations or large volumes should be conducted in a biological safety cabinet (BSC).