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Patch Clamp Technique Patch Clamp Technique is a laboratory technique in electrophysiology that allows the study of single or multiple ion channels in cells. This discovery made it possible to record the currents of single ion channels for the first time, proving their involvement in fundamental cell processes such as action potential conduction. Erwin Neher and Bert Sakmann developed the patch clamp in the late 1970s and early 1980s.They received the Nobel Prize in Physiology and Medicine in 1991 for this work. Patch Clamp technique can be applied to a wide variety of cells, but is especially useful in the study of excitable cells such as neurons, cardiomyocytes, muscle fibers and pancreatic beta cells. It can also be applied to the study of bacterial ion channels in specially prepared giant spheroplasts.