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Download Acetate Acetylcholine (ACh)
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Transcript
ACETYLCHOLINE (ACh) Widely used at synapses in the peripheral nervous system. Released at the terminals of: All motor neurons activating skeletal muscle. Many neurons of the autonomic nervous system especially those of the parasympathetic branch. Some synapses in the central nervous system. Acetylcholine is removed from the synapse by enzymatic breakdown into inactive fragments. The enzyme used is acetylcholinesterase. Nerve gases used in warfare (e.g., sarin) and the organophosphate insecticides (e.g., parathion) achieve their effects by inhibiting acetylcholinesterase thus allowing ACh to remain active. Atropine is used as an antidote because it blocks ACh receptors.
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