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Automated Gene Synthesis Machines By Austin Burgess What is a Gene • A gene is a unit of heredity that is transferred from a parent to its offspring and is held to determine some characteristics of the, “Proteins coded directly by genes” What They Do • The genes, also known as oligonucleotides , took twenty years to make a automated gene synthesis machine. • They make oligonucleotides of high quality, to do a broad range of applications. Like the MerMade 192E pictured on the first slide. What is Gene Therapy • Gene therapy is correcting genes responsible for disease development. • The most common form of gene therapy is placing a gene in a nonspecific location within the genome to replace a nonfunctioning gene. The Risks of Gene Therapy • It can cause your immune system to attack the virus inserted causing organ failure and inflammation. • The virus may spread through more than one cell causing mutated cells and missing genes. • Finally it may introduce a tumor if they are inserted into the wrong spot in the genome, it could lead to a tumor. How it Helps Gene Therapy • It synthesizes DNA into column format using standard or modified chemistries. • It takes about three hours to synthesize the DNA into its column format. • They can now use them to program what the gene’s function should be through a gene synthesizer.