Download Research Scientist Oncology Biology/Translational

Research Scientist Oncology Biology/Translational
Crescendo Biologics (www.crescendobiologics.com) is a leading Cambridge-based
biotechnology company developing next generation Humabody® VH therapeutics derived
from the company’s unique transgenic platform. Crescendo is building an exciting portfolio of
novel oncology products in areas of high unmet need, including both Immuno-Oncology
modulators and Humabody Drug Conjugates (HDCs) that leverage the advantages of the
Humabody format.
We are looking for a Research Scientist with a strong biology background to carry out
preclinical biology and translational pharmacology experiments to help drive Crescendo’s
novel Humabody projects into the clinic.
The role will include:
Developing and delivering low/medium throughput biology assays and datasets to support
the progression of novel Humabody drug discovery projects in Oncology with a focus on
immuno oncology and Humabody drug conjugates.
Developing and performing in vitro and ex-vivo assays to assess the activity and mechanism
of action of Humabody leads and candidates.
Being part of a cross-functional project team by bringing knowledge and understanding of
relevant biological assays and mechanisms to project work to support progression of
projects.
Carrying out a range of in vitro techniques such as ELISA, FACS analysis, functional cell based
assays, immune cell and tumour cell culture.
Performing assays on tissue and plasma samples in order to measure PK and PD endopoints.
Co-ordinating and tracking sample transfer between CROs.
Expertise/Knowledge
The successful candidate will have demonstrated knowledge and experience of some of the
following
Design and execution of a range of in vitro assays eg ELISA, FACS and cell based functional
assays eg cell proliferation, cytokine release, migration, marker upregulation etc.
Experience of cell culture, aseptic technique and experience with culturing tumour cells and
preferably primary immune cells.
Sound knowledge of assay optimisation and performing medium to low throughput assays.
Practical experience of working with tissue and/or plasma samples in in vitro assay systems.
Knowledge of tumour biology or immunology and tumour microenvironment would be an
advantage.
Experience of drug discovery and antibody therapeutics/biologics would be an advantage.
Person Specification
Degree or PhD or equivalent experience in a field relevant to
biology/pharmacology/immunology or oncology.
Excellent organisational skills and ability to work flexibly to meet deadlines
Motivated by science and oncology drug discovery or translational biology
Independent with the ability to work through plans, generate results and come up with
suggestions for next steps/
Highly organised with good attention to detail
Good communicator
Excellent team worker
In addition, candidates will also be expected to:
Co-ordinate and co-operate with other personnel over the day to day running of the
laboratory
Have excellent abilities in record keeping and maintenance of clearly written laboratory
notebooks to a standard required for publications and patent filings
Contribute to company Health & Safety policies and implementation
Crescendo Biologics offers a competitive compensation package including private medical
insurance, life assurance, pension scheme and membership of the company share option
plan. Our premises are located on the Babraham Research Campus to the south of
Cambridge, and staff members have access to Campus facilities including an on-site nursery,
canteen, gym and sports and social club.
Candidates should be legally entitled to work in the UK.