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Download Thomovsky E, et al. Shock pathophysiology. Compend Contin Educ
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Transcript
Thomovsky E, et al. Shock pathophysiology. Compend Contin Educ Vet 2013;35(8). Glucose Anaerobic Metabolism. Pyruvate cannot enter the TCA cycle and enters the Cori cycle to form lactate. Lactate can be used by the brain and heart in the short term for energy, but it is overall an inefficient source of cellular energy. Aerobic Metabolism. Pyruvate is able to enter the TCA cycle and is converted into large amounts of ATP. 2 pyruvate Oxygen TCA cycle Oxygen Cori cycle 2 lactate 36 2 ATP ATP Figure 1. Aerobic versus anaerobic metabolism. TCA = tricarboxylic acid.
