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Nonspecific immune defenses
The immune system protects your body
from pathogens
Resistance
• Resistance is your bodies ability to defend
against pathogens.
• Your immune system gives you resistance.
physical barriers to disease
• Nonspecific
defense.
– Sweat, oils, &
waxes.
– Mucous
membranes.
– HCL of stomach.
Why you get a fever
• Pathogens that
attack human body
like 98.6° F best.
• Raising temperature
of body increases
effectiveness of
white blood cells.
• Decreases
effectiveness of
pathogen.
Interferon
• Chemical released
by cells infected by
viruses.
• Causes surrounding
cells to resist
infection.
Inflammatory Response
•Inflammatory response occurs when pathogen
penetrates the skin.
• Symptoms:
– Redness
– Heat
– Swelling, pain
• What occurs:
– Damaged cells
release
histamines.
– Causes
vasodialation
– Causes increase
in permeability.
Pair share: explain this picture to your partner.
What is happening in each frame?
Neutrophils
• Most common
white blood cell
• Kill pathogens
using phagocytosis.
• Circulate in blood
stream.
• Migrate towards
site of infection.
• Move out of the
blood stream
Macrophages
• Stationed in certain tissues.
• Destroy by phagocytosis.
• Rid the body of debris and damaged cells.
Natural Killer Cells
• Attack cells
which have been
infected by
pathogen.
• Kills cancer cells.
• Kills by
puncturing cell
membrane.
White board Review
1. List 3 nonspecific
defense barriers.
2. List 3 symptoms of
the inflammatory
response.
3. What do
macrophages do?
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