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Biochemistry 2EE3 Metabolism and Physiological Chemistry 2002 Course Outline Instructor: Dr. Boris S. Zhorov (HSC-4H29, ext. 22049; E- mail: [email protected]) Purpose: To provide a brief introduction to proteins, enzymes and gene expression followed by a more detailed treatment of energy and intermediary metabolism with emphasis on physiological chemistry Learning objectives: Understanding principles of structure and function of biological macromolecules, energy production and utilization by living orga nisms, metabolic pathways, and mechanisms of integration and regulation of metabolism Evaluation of student performance will be based on two tests and a final examination. The final grade will be calculated as follows: first test 30%; second test, 30%, final examination, 40%. Percentage grade will be converted to a final letter (see Table below) % Letter % Letter % Letter % Letter 100-90 A+ 79 - 77 B+ 69 - 67 C+ 59-57 D+ 89 - 85 A 76 - 73 B 66 - 63 C 56-53 D 84 - 80 A72 - 70 B60-62 C52-50 DAll percentage grades within 0.5% of the next letter grade will be reviewed % 49-0 Letter F Questions: Students are encouraged to ask questions in the class and during office hours. Textbook: Fundamentals of Biochemistry. D.Voet, J.G.Voet, and C.W.Pratt. Wiley & Sons Inc. 2001. The textbook contains Biochemical Interactions, a CD ROM providing animations and interactive 3D molecular graphics displays. Lecture notes: http://www.science.mcmaster.ca/biochem Lecture notes are not a substitute for the textbook Academic ethics : Students are asked to reread two documents provided on registration, the Senate Statement on Academic Ethics and the Senate Resolutions on Academic Dishonesty. Students should be sure that they understand the expectations the University has of its scholars, and the possible consequences when these expectations are not met. Schedule of lectures, tests, and class tutorials Place: BSB-147. Time: 5:30 – 6:20 p.m. on Mondays, Wednesdays, and Thursdays Textbook Test Date Lecture # and topic a chapters Biological molecules Mo Jan 7 1. Origin of life. Cell. We Jan 9 2. Energy and molecular interactions Th Jan 10 3. Amino acids Mo Jan 14 4. Structure and function of proteins We Jan 16 5. Nucleic acids 1 1, 6 2, 4, 5 6, 7 3 Lecture # and topic a Date Th Mo We Th Mo We Th Mo We Th Mo We Th Mo We Th Mo We Th Mo We Th Mo We Th Mo We Th Mo We Th Mo We a b Jan Jan Jan Jan Jan 17 21 23 24 28 Textbook chapters 6. Gene expression 7. Carbohydrates 8. Lipids and membranes 9. Enzymes 10. Coenzymes Cell-to-cell communication Jan 30 11. Neurons and neurotransmitters Jan 31 12. Hormones and Receptors Feb 4 13. Ion channels Feb 6 Feb 7 Metabolism Feb 11 14. Overview. High-energy compounds Feb 13 15. Redox reactions Feb 14 16. Glucose catabolism I Mid-term recess 3 8 9, 10 11 Feb 25 Feb 27 Feb 28 Mar 4 Mar 6 Mar 7 Mar 11 Mar 13 Mar 14 Mar 18 Mar 20 Mar 21 Mar 25 Mar 27 Mar 28 Apr 1 Apr 3 Apr 4 Apr 8 Apr 10 14 15 16 16 17 17 17 17. Glucose catabolism II 18. Glycogen metabolism 19. Citric acid cycle I 20. Citric acid cycle II 21. Mitochondrion and electron transport 22. Oxidative phosphorylation 23. ATP. Aerobic metabolism implications 24. Lipid metabolism I 25. Lipid metabolism II 26. Lipid metabolism III 27. Amino acid metabolism I 28. Amino acid metabolism II 29. Amino acid metabolism III 30. Nucleotide metabolism I 31. Organ specialization in metabolism 32. Interorgan metabolic pathways 33. Hormonal control of metabolism Test b Sample questions handing out b E-mailing queries b b Class tutorial Test 13 13 14 19 19 19 20 20 20 22 22 21 21 Topics of some lectures may be subject to change. Material from several chapters of the textbook will be used. Test returning Sample questions handing out E-mailing queries Class tutorial Test Test returning Sample questions handing out E-mailing queries Class tutorial Final examination