* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Download Assn5
Survey
Document related concepts
Proteolysis wikipedia , lookup
Oxidative phosphorylation wikipedia , lookup
Plant nutrition wikipedia , lookup
Fatty acid metabolism wikipedia , lookup
Biochemical cascade wikipedia , lookup
Fatty acid synthesis wikipedia , lookup
Genetic code wikipedia , lookup
Evolution of metal ions in biological systems wikipedia , lookup
Natural product wikipedia , lookup
Deoxyribozyme wikipedia , lookup
Citric acid cycle wikipedia , lookup
Nitrogen cycle wikipedia , lookup
Metalloprotein wikipedia , lookup
Peptide synthesis wikipedia , lookup
Oligonucleotide synthesis wikipedia , lookup
Biochemistry wikipedia , lookup
Artificial gene synthesis wikipedia , lookup
Transcript
Biochemistry 411/602 ASSIGNMENT 5 Due week of April 26 1. Show the biochemical pathway for each of the following: a) the synthesis of L-proline starting with L-arginine b) the synthesis of L-cysteine starting with L-methionine c) the synthesis of L-serine starting with L-asparagine d) the synthesis of norepinephrine starting with L-phenylalanine 2. How many amino acids are required to synthesize creatine? Draw the structure of creatine and show the contribution of each to the structure. 3. The biosynthesis of purines and pyrimidines requires 5-phosphoribosyl--pyrophosphate (5’PRPP). Starting with glucose, show how 5’-PRPPis synthesized. 4. Starting with 5’-UMP, show the pathway for the biosynthesis of 2-deoxycytidine-5’monophosphate (5’-dCMP). 5. Describe a biochemical procedure that selectively inhibits DNA synthesis, but has no affect on RNA synthesis. Answer this question by identifying a compound that inhibits one of the enzymes you showed in question 4. 5 Point Bonus 1. Beginning with NaNO2, trace the path of nitrogen into the structure of ATP and CTP in lima beans. List all stable nitrogenous intermediates in the pathways. The final steps should show the nitrogen donors for each of nitrogen atoms in these molecules. (HINT: Work backwards. You will use the same donor more then once and in multiple reactions. You need not show the synthesis of carbon skeletons for Krebs cycle compounds. Be sure you account for all of the amino group donors)