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The neurotransmitter phenotype of central neurons is controlled by basic helix-loop-helix transcription factors. A. In the cerebral cortex GABAergic and
glutamatergic neurons derive from different proliferative zones and are specified by different basic helix-loop-helix (bHLH) transcription factors.
Glutamatergic pyramidal neurons derive from the cortical ventricular zone, and their differentiation depends on the activities of neurogenin-1 and -2. The
differentiation of GABAergic interneurons in the ganglionic eminences of the ventral telencephalon depends on the bHLH protein Mash1. These neurons
migrate dorsally to supply the cerebral cortex with most of its inhibitory interneurons (see Figure 53–8).
B. In the developing
cerebellum and
GABAergic
glutamatergic
neurons
also derive
fromFifth
different
Source: Differentiation
Survival and
of Nerve
Cells, Principles
of Neural
Science,
Editon proliferative zones and are specified by bHLH
transcription factors. Glutamatergic granule cells migrate into the cerebellum from the rhombic lip, settle in the inner granular layer (IGL), and are specified
Citation: Kandel ER, Schwartz JH, Jessell TM, Siegelbaum SA, Hudspeth AJ, Mack S. Principles of Neural Science, Fifth Editon; 2012 Available
by the bHLH protein Math-1. GABAergic Purkinje neurons migrate from the deep cerebellar proliferative zone, settle in the Purkinje cell layer (PCL), and
at: http://mhmedical.com/ Accessed: May 10, 2017
are specified by the bHLH protein Ptf1a.
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