Download CHEE 3466 (Required) Biological and Physical Chemistry

CHEE 3466 (Required)
Biological and Physical Chemistry
Catalog Data: Biological and Physical Chemistry Cr. 4. (4-0). Introduction to
biochemistry. Physical-chemical topics including kinetics and adsorption.
Prerequisites: CHEE 3333 and CHEM 3332.
Instructor: Dr. Peter G. Vekilov,
Professor of Chemical and Biomolecular Engineering
Office: S233, phone: (713) 743-4315; e-mail: [email protected]
Assistants:
Book:
Ye Li
,
Anupam Aich
Ivan Liadi
S232 [email protected]
S232 [email protected]
S194 [email protected]
Physical Chemistry: With Applications to the Life Sciences by David S.
Eisenberg, Donald M. Crothers Addison-Wesley Pub Co; ISBN:
080532402X
Additional text:
Lehninger's Principles of Biochemistry, Third Edition, by David
Nelson, and Michael Cox, W.H. Freeman, NY 2000
Additional text:
J. M. Smith, H. C. Van Ness and M. M. Abbot,
Introduction to Chemical Engineering Thermodynamics,
McGraw-Hill Book Company, Boston
Homework: will be assigned every lecture and collected at the beginning of the
Monday class in the following week. Work on the homework is a prerequisite
for a successful passage of all tests and exams.
Tests: three tests on material taught in the class will be given through the semester:
Test I – on February 14, Test II – on March 9, Test III – on April 25.
Spring Break: March 14-19
Last class: Monday, May 2, 2011
Final Examination: Friday, May 6, 2011, 11 am-2 pm, in this auditorium
Grading: 10 % homework, 50 % midterm tests, and 40 % final exam
Prerequisites by topics:
 Theory of chemical bond
 Fundamentals of organic chemistry
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Theory of acids and bases
Thermodynamics of multicomponent systems
Non-ideality
Calculus and elementary differential equations
Expected Student Outcomes
Demonstrate understanding of the physico-chemical principles underlying the structures
and functions of biological macromolecules (a).
Demonstrate ability to use of techniques for analyzing the response of biological
systems to pH changes (a).
Demonstrate understanding of the thermodynamic concepts associated with
hydrophobicity (a)
Demonstrate proficiency with the fundamentals of statistical thermodynamics (a).
Demonstrate proficiency with the fundamentals of chemical kinetics (a)
Demonstrate understanding (limitations and capabilities) of chemically reacting
systems kinetics (a)
Planned Lecture Outline
1. Biomolecules: structure and function; chirality
2. Water, weak interactions, acidity and buffers
3. Nucleotides and nucleic acids
4. Biological applications of thermodynamics
5. Chemical and biochemical kinetics
6. Equilibrium constant
7. Reaction mechanisms
8. Entropy and enthalpy of activation
9. Diffusion limited kinetics
10. Catalyses and enzyme kinetics
11. Fundamentals of statistical mechanics
12. The virial expansion
13. Discussion and preparation for final examination
Prepared by: Peter Vekilov
January 2011
Appendix
ABET Outcome, Criterion 3
(a) an ability to apply knowledge
of mathematics,
science and engineering.
(b) an ability to design and
conduct experiments as well as to
analyze and interpret data.
(c) an ability to design a system,
component, or process to meet
desired needs within realistic
constraints such as economic,
environmental, social, political,
ethical, health & safety,
manufacturability, and
sustainability.
(d) an ability to function on
multi-disciplinary teams.
(e) an ability to identify,
formulate and solve engineering
problems.
Program-Specific Outcomes
• Use chemistry and physics concepts to set up and solve chemical
engineering problems
• Use mathematical tools to solve chemical engineering problems
• Select appropriate experimental equipment and techniques
necessary to solve a given problem
• Evaluate and interpret experimental results using statistical tools
and chemical engineering concepts
• Apply material and energy balance concepts to design a unit
operation
• Define objectives and perform the design of an integrated chemical
process under realistic constraints
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(f) an understanding of
professional and ethical
responsibility.
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(g) an ability to communicate
effectively.
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(h) the broad education necessary
to understand the impact of
engineering solutions in a global,
economic, environmental, and
societal context.
(i) a recognition of the need for
and an ability to engage in lifelong learning.
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(j) a knowledge of contemporary
issues.
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(k) an ability to use the
techniques, skills, and modern
engineering tools necessary for
engineering practice.
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Define roles and responsibilities to align with capabilities of team
members and fulfill project requirements
Develop and carry out a project plan through team work
Translate an engineering problem into a mathematical model or
other suitable abstraction
Use mathematical model or other suitable abstraction to solve an
engineering problem and interpret results
Demonstrate knowledge of professional code of ethics.
Identify ethical issues and make decisions for a chemical
engineering problem.
Make presentations that are factual and tailored to the audience
Can communicate in writing to non-technical and technical
audiences
Understand the impact of chemical engineering solutions in a
global, economic, environmental, and societal context.
Recognize the importance of advanced education and development
opportunities
Identify, retrieve, and organize information necessary to solve
open-ended problems
Know the interplay between current technical and societal issues
Know the recent history, current status, and future trends of
chemical engineering
Use modern software to solve chemical engineering problems
Understand how to operate equipment relevant to chemical
engineering systems