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Bone Up on Osteoporosis
By Joyce Seabolt, LPN
LPN2007, November/December 2007
2.0 ANCC/AACN contact hours
Online: www.nursingcenter.com
© 2007 by Lippincott Williams & Wilkins. All world rights reserved.
Growing Bones

Osteoblasts: form new bone cells in a process called
remodeling

Osteocytes: maintain bone as a living tissue

Osteoclasts: break down calcium and phosphorus in a
process called resorption
Possible Causes of
Osteoporosis







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personal history of nontraumatic fracture
low peak bone mineral density
body weight less than 27 pounds
unexplained cessation of menstruation
anorexia nervosa
low lifetime calcium intake
vitamin D deficiency
lifestyle lacking weight-bearing exercises
Possible Causes of
Osteoporosis



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alcohol consumption of more than two drinks per day
cigarette smoking
family history of nontramautic fracture (primary relative)
and/or osteoporosis
long-term use (more than 6 months) of corticosteroids,
medroxyprogesterone (Depo-Provera), thyroid
hormones, anticonvulsants, aluminum-containing
antacids, methotradate sodium, cholestryamine
white or Asian race
Risk Factors for Osteoporosis

Age - Older people more likely to develop osteoporosis

Race - White and Asian most susceptible

Sex - Women lose bone more rapidly than men

Heredity - Family history increases chances

Low weight and bone structure

Estrogen deficiency or menopause
Risk Factors for Osteoporosis

Contributing medical conditions/medications - Celiac
disease, corticosteroids, antiseizure medications

Excessive alcohol use or smoking

Diet low in calcium and vitamin D

Inactivity and lack of weight-bearing exercise

Lack of exposure to sunshine
Types of Osteoporosis

Primary - Most common in 95% of cases; occurs
spontaneously

Secondary - Results from a disease such as diabetes or
a medication such as steroids
Diagnosis

Bone mineral density (BMD) test - Best determinant of
bone health
-- Dual energy x-ray absorptiometry (DXA) - gives
information to calculate fracture risk
-- T-score with negative numbers = bone loss
More Diagnostic Tests

Computed tomography scan (CT) - can measure
spinal bone density

Ultrasound - evaluates bones strength using sound
waves to measure bone density
Blood Tests to Evaluate and
Monitor Osteoporosis

calcium levels

estradiol levels

vitamin D levels

follicle-stimulating
hormone

thyroid function

testosterone

osteocalcin levels

parathyroid hormone
levels
Urine Tests

24-hour urine to measure calcium metabolism

NTx, a new biochemical urine test that shows rate of
bone breakdown
Lifestyle Modifications

Eat diet rich in calcium and vitamin D
- 1000 to 1500 mg calcium over 25 years of age
- 400 to 1500 mg calcium in children and young adults
- 400 to 800 international units of vitamin D

Exercise
- as little as 5 to 6 weight-bearing exercises two to three
times a week
- walking, dancing, climbing
Lifestyle Modifications

Fall prevention
- wear low-heeled, nonskid shoes
- remove clutter from walkways
- secure or remove all rugs
- place skid-proof mats next to tubs and sinks
- make sure walkways are lit
Medication Choices

Biphosphonates - slow bone loss
- Fosamax
- Actonel
- Boniva

Selective estrogen receptor modulators - decrease
bone resorption
- Estiva
Medication Choices

Cacitonin-salmon - peptide hormone inhibits bone
breakdown
- Miacalcin
- Calcimar
- Fortical
- Cibacalcin

Hormone replacement therapy - decreases bone
breakdown in menopausal women (discuss with health
care provider due to many adverse effects)
Scary Statistics

10 million Americans over age 50 have osteoporosis.

About 1.5 million people have an osteoporosis-related
fracture each year.

About 20% of people with a hip fracture end up in a
nursing home within the year.

About 20% of people with a hip fracture will die within the
year due to complications.
Scary Statistics

The World Health Organization reported that 50% of
people with hip fractures become permanently disabled;
they expect the number of hip fractures due to
osteoporosis to triple by the year 2050, bringing the
worldwide total number of hip fractures to 6 million.

The lifetime risk of fracture in a 50-year-old woman is
about 40%.