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Introducing InforSense
Kanishka Karunanayake
[email protected]
Why Scientific Workflow?
Today researchers and decision-makers need
effective and timely access to the right information,
expertise and derived knowledge to fuel innovation
and drive productivity
The Workflow Paradigm
 Describes the process of transforming and analysing data to
deliver the desired insights
 And provides the glue to integrate distributed applications
Proprietary and Confidential © InforSense Ltd
What does InforSense do?
We provide a workflow engine that:
 Provides an open Integrative Analytics environment
that ties together your information resources and
software applications across domains and functions
 Supports innovation and capture of the best work
practices of your scientific/business decision making
 Leverages the scalability of Oracle
We provide workflow warehousing to:
 Manage decision making processes across your
organisation
 Construct an enterprise process/workflow knowledge
bank where it is easy to modify and reuse workflows
We provide flexible workflow deployment
engines to:
 Turn your workflows into reusable decision services in
a manner best suited to your users (web services,
client/server, portals, or .net clients)
 Provide the appropriate capabilities to your
researchers, informaticians, and managers
Proprietary and Confidential © InforSense Ltd
Ubiquitous Workflows, Warehouses
and Deployment Engines
Workflow
Warehouse
Deployed
Applications
Expert User
/Analyst
Integrative Analytics Workflow Environment
Analytics
Experiment
& design
Enumeration &
descriptors
Lab &
analytical
data
ID Business
Solutions
Compound &
activity data
Databases &
documents
Visualization
Heterogeneous Data, Applications, Analytic Components
Proprietary and Confidential © InforSense Ltd
InforSense Architecture Overview
J2EE JBoss
App Server Tier
Client Tier
Third Tier Services
InforSense Client
InforSense .net Client
RMI
SOAP
3rd Party Clients
RMI/SOAP
Deployment Strategies
InforSense EJBs
Userspace
Execution
Data management
Node SDK
Server API
RDBMS
JDBC
SOAP
Webservices
RMI
Command Line Strategy
Java Component Strategy
Inforsense
Web Service
Engine
JAAS
Web Services Strategy
HTTP/HTTPS
Native
Executables
Batch
Systems
Workflow
Warehousing
Sun Grid Engine, LSF
Authentication
services
Browser
JAAS e.g. LDAP,
ActiveDirectory
Oracle
Proprietary and Confidential © InforSense Ltd
Openness: Working with any
vendors
Searching Oracle DB
using JChem Cartridge
Output SD
file
Combine PP data
columns with
ongoing analysis
Analyse in
PP
Input list to
pipeline pilot
Retrieve data
from ABase
Analyse in Spotfire
and return results
set to KDE for
further analysis
Add derived
columns from
xls file
Output list of
IDs for
screening
Proprietary and Confidential © InforSense Ltd
Deployment: Building Personal
Applications
Deployment : Vertical applications created from
workflows
Create workflow using InforSense client
Deploy by point and click GUI
Molecular Input
View Result
Deployed Workflow
 Define properties
 Define actions
 Deploy
Proprietary and Confidential © InforSense Ltd
Deployment: Building Personal
Applications
Proprietary and Confidential © InforSense Ltd
ChemAxon Integration Path
Proprietary and Confidential © InforSense Ltd
Workflows incorporating ChemAxon
Technology
<Workflow Movies>
Proprietary and Confidential © InforSense Ltd
Analysis of Lymphoma Genomic Data -Searching for Relevant Genes and New Drugs
Demo implements an expanded version of an original method
reported in: Shipp et al Nature Medicine January 2002 Volume 8
Number 1 pp 68 – 74.
Methodology
Data Acquisition
Multiple Types of Analysis
Relevant Results
• Genes
Visualization
Gene Expression
Data
Relevant Genes
• Papers
Literature Search/Text Mining
Candidate Drug Search
Prediction Model
Patient Data
Cellular Pathway Analysis
• Pathways
• Candidate Drugs
E.g. Eli Lily’s
Protein Kinase C
Inhibitor LY317615
Sequence Analysis
Proprietary and Confidential © InforSense Ltd
Proprietary and Confidential © InforSense Ltd
Proprietary and Confidential © InforSense Ltd
Drug Search
Proprietary and Confidential © InforSense Ltd
ROI - Integrative Analysis Example
Without InforSense
•3 People
Novel Indication for existing
Protein Kinase C Inhibitor LY317615
•90 Days
•1000’s of lines of customised code
With InforSense
•1 Person
•10 Days
•60 Nodes
Novel Discovery & Knowledge
•Share reusable workflows and data
•Collaborate on all aspects of work
•Flexibility, automation and reproducibility
•Rapid application deployment
Workflows
Proprietary and Confidential © InforSense Ltd
InforSense Introduction &
Mission
Company founded Nov 1999 to
commercialize Imperial College large
scale integrative analytics IP
London (HQ)
Shanghai
Cambridge,
MA
European
Field Office
Japanese
Distributors
50 staff plus 20 developers in Shanghai
6 out of top 15 pharma are customers
Mission:
Provide market leading integrative
analytics software to enable
enterprises to create, integrate, and
leverage decision making knowledge
more effectively
Windber Research Institute
Proprietary and Confidential © InforSense Ltd
Customer Comments…
“... The challenge is both to facilitate this dynamic and iterative [decision
making] process, and at the same time, capture the key decisions that are
made so they can be improved over time.”
“… InforSense workflow technology provides a scalable integration
solution, enabling our scientists to develop, enhance and share discovery
services. With InforSense, we will ensure that the technology we build our
infrastructure upon is an industry standard.”
– Stephen Calvert, Vice President, Cheminformatics, GSK.
“… [InforSense’s] proven multi-platform integration will enable
us to exploit our existing informatics investment and provide a
highly extensible discovery environment for the future."
– Dr. Herbert Köppen, Head of Chemoinformatics, Boehringer Ingelheim
“I believe this is the best software for analysis, visualization and
integration …”
– Dr. Keisuke Imai, Chief Technical Scientist, Fujisawa Pharmaceutical Co.
Proprietary and Confidential © InforSense Ltd
Contact InforSense
InforSense Limited
459a Fulham Road
London SW10 9UZ (UK)
InforSense LLC
25 Moulton Street
Cambridge, MA 02138 (USA)
t: +44 (0) 20 7808 9500
f: +44 (0) 20 7808 9501
t: +1 617 547 2500
f: +1 617 547 2772
Additional information can be found at
www.inforsense.com
For enquiries, product information and collaboration, please email me at:
[email protected]
Proprietary and Confidential © InforSense Ltd