Download Population genetics and vaccines - Lectures For UG-5

VACCINOLOGY (BIO-301)
Credit Hrs 3(2-1)
Dr. Aneela javed
Objectives
The aim of the course is to
•Introduce students to the various disciplines associated with
vaccinology including
•vaccine development
•The relevant basic sciences such as immunology, microbiology and
molecular biology
•clinical trials
•vaccine safety, ethics
•vaccine-economics
•vaccination strategies and evaluation of vaccines.
Course Contents
•An introduction to Vaccinology
•Vaccine history and types
•Epidemiologic basis of Vaccinology
•Role of combination vs. single vaccines
•The immune responses to the pathogen & vaccine
development
•Immunology of Vaccines
•Antigen and Vaccine Delivery Strategies
•Determinants of Vaccine Availability
•Vaccine development strategies: New approaches
•Live versus attenuated vaccines
•Role of multinational companies in vaccines production
•DNA as vaccine
•Peptide & Subunits vaccine
•Adjuvants in vaccines
•Population Genetic analysis: immunity
to vaccine
•Recombinant vaccine
•Animal models of vaccine testing
•Vaccine Delivery Systems
•Practical issues in relation to trials
•Ethical issues related to clinical
evaluation of vaccines
•Vaccine safety
•Review of vaccines in current use
•Vaccine-economics
•Future of Vaccines/Vaccination
Course Contents
PART 1 : INTRODUCTION
•
Definition
•
History
•
Types
•
Combination vs single vaccine
Part 2: Principles of Vaccine Design
Immunologic Memory: T and B Cells memory
• Antigen Processing and Presentation by MHC Class I, II, and Nonclassical Molecules
• Understanding the Mucosal Immune System for Better Mucosal Vaccine Design
Part 3: ANIMAL MODELS FOR VACCNE TESTING
• Utility of Mouse Models in Vaccine Design and Development,
• Utility of Nonhuman Primate Models for Vaccines,
Part 4: Delivery Systems
•Transcutaneous Immunization via Vaccine Patch Delivery System
•Needle-free Jet Injection for Vaccine Administration
•Oral Vaccines: An Old Need and Some New Possibilities
Adjuvants:
Part 5: Evaluating Vaccine Efficacy
• Trials in human and practical issues
Part 6: Regulatory Considerations
•Regulatory Issues
•Role of international companies
•Vaccine economics
PART 7: Population genetics and vaccines
• Ethical issues
• Vaccine safety
Antigen Engineering
Sequence-Based Computational Approaches to Vaccine Discovery and Design
Antigen Discovery for Vaccines Using High-throughput Proteomic Screening
Technologies,
Phage Libraries
Attenuated Bacterial Vaccines
Virus-like Particles as Antigen Scaffolds
Recombinant MVA vaccines: Optimization, Preclinical, and Product Development
Recombinant Adenoviruses for Vaccination
Recombinant Avipoxviruses,
Intracellular Facultative Bacterial Vectors for Cancer Immunotherapy
Nucleic Acid Vaccination,
Artificial Antigen-presenting Cells: Large Multivalent Immunogens
BOOKS
Recommended Books:
The Vaccine Controversy: The History, Use, and Safety of Vaccinations by
Kurt Link; Praeger.
Novel Vaccination Strategies by Stefan H. E. Kaufmann.
Vaccinia, Vaccination, Vaccinology - Jenner, Pasteur and Their Successors
by Pasteur, B. Fantini, S.A. Plotkin
Progress in Vaccinology by Richard Moxon.
The Virus and the Vaccine: Contaminated Vaccine, Deadly Cancers, and
Government Neglect by Debbie Bookchin and Jim Schumacher.
Rules
1. 2 OHTs….skip rule…. makeup
2. 6 quiz/surprise test…no makeup
3. Class participation….
4. Assignments/Presentation /project
•Review of vaccines in current used in pakistan
PRE- REQUISITE(s)
Cell Biology, Microbiology and Virology, Basic
Immunonology
REVISION
Cell Biology, Microbiology and Virology, Basic
Immunonology
HISTORY
1796
TYPES
infectious bovine rhinotracheitis (IBR)
Bovine viral diarrhoea virus (BVDV)
TOXICITY
ANTIGENICITY
FORMALIN
ADVANTAGES