Download NLM Informatics Training Conference - 2016

NLM Informatics Training Conference - 2016
ABSTRACT INSTRUCTIONS
Instructions for Plenary/Focus Session/Poster Abstracts
Due: March 7, 2016 – 5:00 p.m. EST
1. Submissions for each presentation should consist of a title, an author list, and an abstract (together on
one page). Example is attached.
2. The title should not exceed 75 characters.
3. The first author will be the presenter at the meeting. He/she must be a trainee currently supported by
the NLM, CDC or VA. Up to four additional authors may be listed. Authors should be listed by first
name, middle initial (optional), last name, and University or Institution—with authors separated by
commas and no period after the middle initial. Do not include academic degrees in the author lists. (In
special cases, trainees who were formerly, but are not currently, supported by NLM may present at the
meeting. In such cases, contact Dr. Florance for clearance before submitting).
4. The abstract should not exceed 200 words.

4a. Below the abstract, indicate whether the work to be presented is proposed
for Plenary, Focus or Poster session.
 4b. Below the abstract, indicate which of the four training tracks is appropriate:
Health care informatics; Bioinformatics/computational biology; Clinical research translational
informatics; Public health informatics
5. Each submission {Together: title, author list, abstract} should be attached as a separate Microsoft Word
document. Example is included below.
6. Submit by e-mail to Christine Ireland ([email protected]) by March 7, 2016, 5:00 p.m. EST. All
submissions should come from the program director or his/her administrative designee (preferably all in
the same e-mail), and not directly from the trainees.
Additional Poster Instructions
Poster dimensions should be 3’ (h) x 5’ (w).
Poster presenters should arrive at the meeting at least half an hour early and check in at the front desk
where they will be assigned a number for their poster, with the coordinating number on their nametag.
Power Point Presentations for Plenary or Focus Sessions
In order to ensure that all presentations are loaded onto the conference room laptops prior to the meeting,
please have all trainees submit their final presentations electronically (in Power Point format) to Christine
Ireland at [email protected] by COB June 16, 2016. Backup files should also be brought to the
meeting on USB format.
(EXAMPLE ABSTRACT)
Computational Modeling of Genome-Wide Targeting of Somatic
Hypermutation
Authors:
Jamie L Duke, Man Liu, David G Schatz, Steven H Kleinstein, Yale University
Abstract:
Activation Induced Cytidine Deaminase (AID) is required for somatic hypermutation (SHM) of
the B cell receptor during normal immune responses. Mistargeting of AID can lead to mutation
of non-immunoglobulin genes and has been proposed as a contributing factor of
tumorigenesis. Through large-scale sequencing, we have shown AID targets a large fraction of
expressed genes in normal B cells and results further suggests the B cell genome is protected by
two distinct processes: targeting of AID to particular genes and gene-specific targeting of highfidelity repair to AID-induced lesions1. From these experiments, we compiled a dataset of 26
Mb of sequence from 180 genes in wild-type and various knockout mouse models. Each gene
exhibits a unique mutation pattern and genomic context offering and unprecedented opportunity
to address several questions concerning AID targeting and mechanism of action.
Our analysis includes a comparison of targeting mechanisms for SHM in non-immunoglobulin
genes versus immunoglobulin genes, and an examination of the potential functional
consequences of aberrant SHM. Additionally, models have been developed to quantitatively
distinguish between genes which are strongly and weakly targeted by AID and SHM with current
results suggesting the mechanism of AID targeting is at least partially shared between
immunoglobulin and non-immunoglobulin genes.
Research Stage: Completed
Proposed for: Plenary or Focus Session; Poster
Research Theme: Bioinformatics/computational biology
E-mail of First Author: _________________________