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Postdoctoral Opening - University of Wisconsin-Madison - Molecular Neurotoxicology Laboratory of Dr. Jeffrey A. Johnson The focus of the laboratory is Molecular Neurotoxicology/Neurodegeneration. Oxidative stress is believed to be a principal factor in the development of many chronic neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's and Amyotrophic Lateral Sclerosis. My laboratory’s goal is to discover ways to increase the defense mechanisms in brain by activating multiple antioxidant defense genes simultaneously through activation of the Nrf2-ARE pathway. In addition, there is an interest in how these diseases are modulated through geneenvironment interactions. Present work in the laboratory is focused on: 1) drug discovery with respect to small molecule activators of the Nrf2-ARE neuroprotective pathway; 2) signaling mechanisms responsible for Nrf2-mediated neuroprotection; 3) role of astrocytes in Nrf2mediated neuroprotection; 4) how environmentally relevant levels of chemical exposure alter disease progression in models of disease; and 5) viral-mediated delivery of Nrf2 into animal models of Alzheimer's Disease, ALS, Huntington's Disease and Parkinson's Disease. Jeffrey A. Johnson, Ph.D. Professor, Division of Pharmaceutical Sciences University of Wisconsin-Madison 6125 Rennebohm Hall 777 Highland Avenue Madison, WI 53705-2222 Telephone: (608) 262-2893 Fax: (608) 262-5345 e-mail: [email protected] https://apps.pharmacy.wisc.edu/sopdir/jeffrey_johnson/index.php
