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KANWAR
IMMUNOPATHOLOGY REVIEW QUESTIONS
1.
Which of the following is/are the component(s)of the immunoregulatory system
involved in the antigen recognition and postrecognition events:
a.
b.
c.
d.
e.
T-cell antigen receptor (TCR)
CD3+ (cluster determinants) antigens
CD4+ cells
monocytes/macrophage
all of the above
ANSWER = E
2.
What percentage of T cells of peripheral circulation carry CD4 and CD8 molecules
on their surfaces:
a.
b.
c.
d.
e.
50%
50%
30%
60%
50%
and
and
and
and
and
30%
40%
60%
30%
30%
ANSWER = D
3.
Which of the following haplotypes have the highest frequency in patients with
ankylosing spondylitis:
a.
b.
c.
d.
e.
HLA
HLA
HLA
HLA
HLA
A8
DR3
B15
B27
DR2
ANSWER = D
4.
Which of the following disorder(s)represent Type-II hypersensitivity:
a.
b.
c.
d.
e.
erythroblastosis fetalis
Goodpasture's syndrome
drug-induced hemolytic anemia
blood transfusion reactions
all of the above
ANSWER = E
5.
What is the most reliable criterion for the diagnosis of an autoimmune disorder:
a.
b.
c.
d.
e.
ANSWER = D
decreased level of complement in the serum
presence of immunoglobulins in the urine
increased level of immunoglobulins in the serum
presence of autoantibody in the serum
presence of lymphocytes in various organs
6.
In erythroblastosis fetalis the antibodies are directed against which of the
following cells:
a.
b.
c.
d.
e.
mother’s RBCs
father’s WBCs
fetal platelets
fetal RBCs
fetal WBCs
ANSWER = D
7.
Which autoantibody’s levels do not fluctuate with the disease activity:
a.
b.
c.
d.
e.
anti-ssDNA
anti dsDNA
anti-RNP
anti-Sm
anti-histone
ANSWER = D
8.
Which form of lupus glomerulonephritis is likely to have very low levels of serum
complement:
a.
b.
c.
d.
e.
mesangial proliferative nephritis
focal proliferative nephritis
diffuse proliferative nephritis
membranous nephritis
tubulointerstitial nephritis
ANSWER = C
9.
Which one of the following is NOT true of the drug-induced lupus erythematosus:
a.
b.
c.
d.
e.
anti-dsDNA antibodies
anti-ssDNA antibodies
anti-histone antibodies
patients are usually slow acetylators
association with HLA-DR4
ANSWER = A
10.
Which of the following is associated with increased incidence of lymphoma:
a.
b.
c.
d.
e.
systemic lupus erythematosus
progressive systemic sclerosis
polymyositis/dermatositis
Sjogren's syndrome
mixed connective tissue disorders
ANSWER = D
11.
Which one of the following is NOT a feature of amyloidosis:
a.
b.
c.
d.
e.
ANSWER = D
nephrotic range proteinuria
cardiac rhythm disturbances
hepatosplenomegaly
proliferation of the cells around the amyloid deposit
macroglossia
12.
Type-I hypersensitivity reaction involves which of the following antibody:
a.
b.
c.
d.
e.
IgG
IgA
IgM
IgD
IgE
antibody
antibody
antibody
antibody
antibody
ANSWER = E
13.
Type-II hypersensitivity reaction involves which of the following:
a.
b.
c.
d.
e.
complement fixing antibodies
opsonizing antibodies
complement-mediated cytolysis
antibody-mediated cellular toxicity
all of the above
ANSWER = E
14.
Which of the following is/are relevant in the pathogenesis of Grave's disease:
a.
b.
c.
d.
e.
autoantibody recognized as a thyroid-stimulating hormone receptor
increase in the levels of triiodothyroinine
autoantibody which perhaps evolved through idiotypic-anti-idiotypic network
all of the above
none of the above
ANSWER = D
15.
Which of the following is/are the relevant feature(s) of Myasthenia gravis:
a.
b.
c.
d.
e.
relatively low incidence of thymoma
increased muscle contraction
autoantibody directed against acetylcholine receptor
all of the above
none of the above
ANSWER = C
16.
Which of the following is/are the relevant feature(s) of pernicious anemia:
a.
b.
c.
d.
e.
an autoantibody directed against the erythroid precursors of bone marrow
an autoantibody interfering in the absorption of gastric intrinsic factor
increased secretion of hydrochloric acid by the gastric mucosa
all of the above
none of the above
ANSWER = B
17.
Which autoantibody(ies) is/are diagnostic for systemic lupus erythematosus:
a.
b.
c.
d.
e.
ANSWER = D
anti-dsDNA
anti-Sm
anti-histone
a and b
a, b and c
18.
Which of the following is characteristic of mixed connective tissue disorders:
a.
b.
c.
d.
e.
immunofluorescence of extracellular matrices
nucleolar immunofluorescence
homogeneous nuclear immunofluorescence
peripheral nuclear immunofluorescence
speckled nuclear immunofluorescence
ANSWER = E
19.
Which of the following proteins DO NOT undergo proteolytic cleavage prior to
deposition:
a.
b.
c.
d.
e.
immunoglobulin light kappa chain
serum amyloid associated protein
immunoglobulin light lambda chain
transthyretin
all of the above
ANSWER = D
20.
What is/are the essential component(s) of a typical amyloid deposit:
a.
b.
c.
d.
e.
AL or AA fibril protein
amyloid-P component
glycosaminoglycans
all of the above
none of the above
ANSWER = D
21.
Type-III hypersensitivity reaction is characterized by which of the following:
a.
b.
c.
d.
e.
IgE antibody-mediated blood vessel damage
IgA antibody-mediated damage to pharynx
immune-complex-mediated damage to the kidney
allergy to drugs, e.g., penicillin
tuberculosis of lungs
ANSWER = C
22.
Which of the following association(s)is/are correct:
a.
b.
c.
d.
e.
class I HLA antigens : mixed lymphocyte reaction
gamma interferon : activation of mononuclear macrophage
class II HLA antigens : complement deficiencies
ankylosing spondylitis : HLA-D27
all of the above
ANSWER = B
23.
Which of the following match(es) is/are correct:
a.
b.
c.
d.
e.
ANSWER = D
allergic rhinitis: dephosphorylation of mast cell perigranular membrane
Goodpasture syndrome: circulating immune-complex-mediated disease
systemic lupus erythematosus: type II hypersensitivity disease
erythroblastosis fetalis: antibody-mediated disease
all of the above
24.
Which antibody(ies) is/are prevalent in systemic lupus erythematosus patients:
a.
b.
c.
d.
e.
anti-RNP (Sm, Smith)
anti-dsDNA
anti-DNA topoisomerase I
a and b
a, b and c
ANSWER = D
25.
Which of the following clinico-pathological correlation (s) is/are NOT correct:
a.
b.
c.
d.
e.
progressive systemic sclerosis : "honeycomb" appearance of the lungs
Grave's disease : retrobulbar (orbital) mucoid degeneration
Sjögren's syndrome : high incidence of B-cell lymphoma
Thyrotoxicosis : antibody directed against thyroxine
all of the above
ANSWER = D
26.
Asthma exemplifies which of the following type of hypersensitivity reaction:
a.
b.
c.
d.
e.
type-I
type-II
type-III
type-IV
all of the above
ANSWER = A
27.
Which one of the following clinico-pathological correlations is NOT correct:
a.
b.
c.
d.
e.
drug-induced lupus erythematosus : N-acetyltransferase deficiency
systemic lupus erythematosus : Libman-Sacks endocarditis
polyarteritis nodosa : anti-HBsAg & HBsAg:HBsAB in the tissues
progressive systemic sclerosis : ischemic ulcers
mixed connective tissue disorders : presence of anti-Sm antibodies
ANSWER = E
28.
Which one of the following is NOT a diagnostic parameter for an autoimmune
disorder:
a.
b.
c.
d.
e.
presence of autoantibodies in the serum
increased number of plasma cells and lymphocytes in target organs
increased concentration of immunoglobulins in the serum
increased excretion of light chains of immunoglobulins in the urine
responsiveness to steroid treatment
ANSWER = D
29.
Systemic lupus erythematosus involves which of the following organs:
a.
b.
c.
d.
e.
ANSWER = E
skin
kidney
joints
blood vessels
all of the above
30.
Systemic lupus erythematosus is characterized by which of the following:
a.
b.
c.
d.
e.
allergic reactions to drugs
allergy to pollens
anti-dsDNA antibodies in blood
IgE antibody-mediated mucosal damage
delayed hypersensitivity reaction
ANSWER = C
31.
The protein which does not undergo proteolytic cleavage prior to the formation an
amyloid deposit:
a.
b.
c.
d.
e.
amyloid light chain (AL)
amyloid associated (AA) protein
prealbumin
thyrocalcitonin
proinsulin
ANSWER = C
32.
In which one of the following does one observe HBsAG:HBsAb immune complexes:
a.
b.
c.
d.
e.
systemic lupus erythematosus
polyarteritis nodosa
mixed connective tissue diseases
idiopathic dermatomyositis
progressive systemic sclerosis
ANSWER = B
33.
Which one of the following is NOT a feature of mixed connective tissue diseases:
a.
b.
c.
d.
e.
speckled nuclear immunofluorescence
absence of anti-Sm (Smith) antibody
absence of anti-dsDNA antibody
presence of high titers of anti-RNP antibody
presence of anti-centromere antibody
ANSWER = E
34.
Which one of the following is encoded between HLA- A -B & -D loci of MHC complex:
a.
b.
c.
d.
e.
class I antigens
class II antigens
2-microglobulin
complement components (C2 and C4)
a and b polypeptide chains
ANSWER = D
35.
The patient's serum autoantibody exhibits speckled nuclear fluorescence, and it
is nonreactive towards dsDNA & Smith(Sm) antigens. The most likely diagnosis is:
a.
b.
c.
d.
e.
ANSWER = D
systemic lupus erythematosus
discoid lupus erythematosis
Sjögren's syndrome
mixed connective tissue disorders
scleroderma
36.
Hypergammaglobulinemia with electrophoretic monoclonal peak is diagnostic of:
a.
b.
c.
d.
e.
cirrhosis of liver
chronic infection
multiple myeloma
Sjögren's syndrome
systemic lupus erythematosus
ANSWER = C
37.
Which one of the following associations is NOT correct:
a.
b.
c.
d.
e.
Hashimoto thyroiditis: Hürthle cells
polyarteritis nodosa: necrotizing panarteritis
Wegener's granulomatosis: necrotizing nasopharyngeal granulomas
Goodpasture's syndrome: crescentic glomerulonephritis
scleroderma: necrotizing pulmonary granulomas
ANSWER = E
38.
Which of the following associations is/are NOT correct:
a.
b.
c.
d.
e.
transcobalamin deficiency: selective leukopenia
DiGeorge syndrome: hypoplasia of thymus
severe combined immunodeficiency: defective interactions of pre-T cells
with thymic epithelium
Bruton's X-linked agammaglobulinemia: defective maturation of pre-B cells
myasthenia gravis: thymoma
ANSWER = A
39.
Which form of lupus nephritis is most likely to present as nephrotic syndrome:
a.
b.
c.
d.
e.
focal lupus nephritis
diffuse proliferative lupus nephritis
mesangial lupus nephritis
membranous lupus nephritis
none of the above
ANSWER = D
40.
Which of the following is/are feature(s) of drug-induced lupus erythematosus:
a.
b.
c.
d.
e.
patients are "slow acetylators"
patients develop anti-single stranded DNA (ssDNA) antibodies
patients on anticonvulsant therapy can develop lupus-like syndrome
patients develop antinuclear antibodies
all of the above
ANSWER = E
41.
Low complement levels are seen in which form of lupus glomerulonephritis:
a.
b.
c.
d.
e.
ANSWER = D
membranous form
mesangial-proliferative
focal proliferative
diffuse proliferative
all of the above
42.
Which of the following is/are NOT a feature of drug-induced lupus erythematosus:
a.
b.
c.
d.
e.
patients develop antihistone antibodies
patients are "slow acetylators"
patients exclusively develop anti double-stranded DNA (dsDNA) antibodies
patients develop anti single-stranded DNA (ssDNA) antibodies
patient’s symptoms disappear with the discontinuation of the offending drug
therapy
ANSWER = C
43.
Which of the following association(s) is/are correct:
a.
b.
c.
d.
e.
speckled nuclear immunofluorescence: mixed connective tissue diseases
nucleolar immunofluorescence: scleroderma
peripheral nuclear immunofluorescence: diagnostic of SLE
a and b
a, b and c
ANSWER = E
44.
Which of the following is/are NOT usual characteristic(s) of lupus erythematosus:
a.
b.
c.
d.
e.
Liquefactive degeneration of the basal layers of epidermis
hypocomplementemia
interstitial pulmonary fibrosis
nonbacterial verrucous (Libman-Sacks) endocarditis
nonerosive synovitis
ANSWER = C
45.
Which of the following is/are the secondary mediator(s) of inflammation:
a.
b.
c.
d.
e.
histamine
heparin
eosinophilic chemotactic factor of anaphylaxis (ECF-A)
leukotriene
none of the above
ANSWER = D
46.
Which of the following associations is NOT correct:
a.
b.
c.
d.
e.
Hashimoto's thyroiditis: consistently increased serum levels of thyroxin
myasthenia gravis: easy fatigability of muscles
Grave's disease: anti-thyroid stimulating immunoglobulins
pernicious anemia: degeneration of spinal dorsal and lateral tracts
Goodpasture syndrome: anti-basement membrane antibody
ANSWER = A
47.
Which of the following associations is NOT correct:
a.
b.
c.
d.
e.
ANSWER = D
anti-ssDNA: drug-induced lupus erythematosus
excessive production of collagen: progressive systemic sclerosis
(scleroderma)
fibrinoid necrosis: polyarteritis nodosa
anti IgG/anti-Kappa chain: amyloidosis
anti-tRNA synthetase: polymyositis
48.
Which of the following associations is NOT correct:
a.
b.
c.
d.
e.
lupus erythematosus: anti-dsDNA antibody
scleroderma: anti-Scl 70 antibody
myasthenia gravis: anti-acetylcholine receptor antibody
Wegener's granulomatosis: antineutrophil cytoplasmic antibody
Hashimoto's thyroiditis: anti-thyroid stimulating hormone (TSH) receptor
antibody
ANSWER = E
49.
Pulmonary tuberculosis is characterized by which of the following:
a.
b.
c.
d.
e.
damage to lungs by repeated asthamtic attacks
antibody mediated damage to the lungs
damage to lungs caused by primary mediators of inflammation
delayed cell-mediated damage to the lungs
all of the above
ANSWER = D
50.
Drug-induced lupus erythematosus is characterized by which of the following:
a.
b.
c.
d.
e.
patients develop anti-ssDNA antibodies
patients have deficiency of liver N-acetyltransferase
patients develop anti-histone antibodies
patients become asymptomatic after drug withdrawl
all of the above
ANSWER = E
51.
Crithidia lucilae protozoan test is used in the diagnosis of systemic lupus
erythematosus since it utilizes the presence of dsDNA in the following:
a.
b.
c.
d.
e.
in
in
in
in
in
its
its
its
its
its
cytoplasm diffusely
plasma membrane
undulating membrane
kinetoplast
flagella
ANSWER = D
52.
A positive indirect Coomb’s indicates the following:
a.
b.
c.
d.
e.
presence of antibody
presence of antibody
presence of antibody
presence of antibody
all of the above
on
on
on
in
the plasmalemma of RBCs
the plasmalemma of leukocytes
erythryoid precursor cells
the serum
ANSWER = D
53.
Immunodeficiency of T-cells is associated with:
a.
b.
c.
d.
e.
ANSWER = E
susceptibility to
susceptibility to
susceptibility to
susceptibility to
all of the above
viral infections
fungal infections
mycobacterial infections
protozoal infections
54.
Which one of following is NOT a feature of acquired immune deficiency syndrome:
a.
b.
c.
d.
e.
association of Kaposi’s sarcoma
pneumocystic carini infection
CD4+ T-cell to CD8+ T-cell ratio more than two
central nervous disorders
lymphadenopathy
ANSWER = C
55.
CD4+T-cells have receptors for which of the following antigens of human
immunodeficiency virus:
a.
b.
c.
d.
e.
p41
p24
p18
gp120
gp21
ANSWER = D
57.
Which of the following statement(s) is/are correct:
a.
b.
c.
d.
e.
CD4+T cell has a receptor for p24 protein of human immunodeficiency virus
(HIV)
a reversal of CD4+ to CD8+ T cells is observed in HIV infection
plasma cells or mature B cells are always seen in organs affected by
amyloidosis associated with immunocytic dyscrasias
proteolytic cleavage of the precursor protein is an absolute requirement
for the formation of amyloid deposit in the target tissues
all of the above
ANSWER = B
58.
52-year-old white male was admitted to the hospital for organ transplant. After
engraftment, he received rigorous immunosuppressive therapy. He then developed
low-grade fever, and chest X-ray revealed diffuse alveolar infiltrates. Which
protozoal organism is likely to be present in the lung biopsy specimen:
a.
b.
c.
d.
e.
Candida albicans
Aspergillus fumigatus
Pneumocystis carini
Histoplasma capsulatum
Giardia lamblia
ANSWER = C
59.
Which cell type undergoes morphologic differentiation prior to the production of
immunoglobulin like IgE?
a.
b.
c.
d.
e.
ANSWER = C
Mast cell
Basophil
B-cell
T-cell
Plasma cell
60.
Cells that are capable of receptor or non-receptor mediated phagocytosis of
particulate matter include:
a.
b.
c.
d.
e.
Lymphocytes, mast cells
T-cells
Basophils, stem cells
Endothelial cells, plasma cells
Neutrophils, macrophages, eosinophils
ANSWER = E
61.
Which cell type contains metachromatic granules and is distributed in the
tissues?
a.
b.
c.
d.
e.
Eosinophil
Basophil
Macrophage
Mast cell
Neutrophil
ANSWER = D
62.
Which one of the following descriptions best characterizes class II MHC complex?
a.
b.
c.
d.
e.
it
it
it
it
it
is made up of a single transmembrane polypeptide chain
includes human leukocyte antigen (HLA) loci A, B and C
includes HLA loci DR, DP and DQ
has 2-microglobulin as part the heterodimeric glycoprotein
restricts the expansion/activation of CD8+ T cells
ANSWER = C
63.
Which one of the following statements best describes systemic lupus
erythematosus?
a.
b.
c.
d.
e.
The clinical presentation is limited to one or two organs only
Immune complex deposition is rather sparse
Autoantibodies are restricted to antibodies against dsDNA
SLE is associated with deficiencies of complement component C2 and C4
Damage in various organs is predominantly mediated by natural killer cells
ANSWER = D
64.
Which one of the following immunopathologic mechanisms is predominantly involved
in autoimmune hemolytic anemia?
a.
b.
c.
d.
e.
Immune complex mediated hemolysis of RBCs
IgE-mediated hypersensitivity
Cell-mediated cytotoxicity
Delayed-type hypersensitivity
Antibody-mediated cytotoxicity
ANSWER = E
65.
Which antibody is relatively more specific for Sjogren syndrome?
a.
b.
c.
d.
e.
ANSWER = C
Antinuclear antibody (ANA)
Anti-Smith antigen
Anti-SSb
Anti-tRNA synthetase
Anti-Scl-70
66.
Which one of the following does NOT cause increased vascular permeability during
an inflammatory response?
a.
b.
c.
d.
e.
Bradykinin
Histamine
Platelet activating factor (PAF)
Complement C5b67
Leukotriene C4
ANSWER = D
67.
Polyclonal B cell activators include:
a.
b.
c.
d.
e.
Lipopolysaccharides
Epstein-Barr virus (EBV)
Cytomegalovirus (CMV)
Protein A
All of the above
ANSWER = E
68.
Which of the following(s) are secreted by mononuclear macrophages?
a.
b.
c.
d.
e.
Tumor necrosis factor
Interleukin-1
Arachidonic acid metabolites
Plasminogen activators
All of the above
ANSWER = E
69.
Which one of the following does NOT represent type-II hypersensitivity reaction?
a.
b.
c.
d.
e.
Tuberculosis
Graves disease
Transfusion reaction
Myasthenia gravis
Hemolytic anemia
ANSWER = A
70.
Which of the following are applicable to type-II hypersensitivity reaction?
a.
b.
c.
d.
e.
Activation of complement and formation of C3b opsonin
Generation of membrane attack complex (C5-9)
Antibody-dependent cell-mediated toxicity
Fc receptor-mediated phagocytosis of the bacteria
All of the above
ANSWER = E
71.
Which one of following is NOT a characteristic of the Arthus reaction where the
lesions resemble those seen in immune complex-mediated vasculitis?
a.
b.
c.
d.
e.
ANSWER = D
Deposition of complement
Leukocytic infiltration
Fibrinoid necrosis
Necrosis associated with granuloma formation
Deposition of the antibody
72.
Autoimmune diseases may NOT be associated with which of the following:
a.
b.
c.
d.
e.
Diminished T suppressor cell function
Abnormal B cell function
Enhanced T helper cell function
Polyclonal B-cell activation
Accentuated activity of mononuclear-macrophage
ANSWER = E
73.
More than 75% of the patients with systemic lupus erthematosus show evidence of:
a.
b.
c.
d.
e.
Libman-Sacks endocarditis
Glomerulonephritis
Central nervous involvement
Raynauds disease
Peripheral neuritis
ANSWER = B
74.
Which of the following is NOT a feature of primary form of Sjogren disease?
a.
b.
c.
d.
e.
Keratoconjunctivitis sicca
Predilection for females
Crescentic glomerulonephritis
Xerostomia
Presence of SSa and SSb antibodies
ANSWER = C
75.
Which of the following is NOT a feature of scleroderma?
a.
b.
c.
d.
e.
Increase of collagen in the reticular dermis
Thickening of the epidermis
Variable lymphoid infiltrates in the dermis
Hyalinization of arterioles
Atrophy of the skin appendages
ANSWER = B
76.
Which of the following statement is NOT true of graft-versus-host disease?
a.
b.
c.
d.
f.
Donor cells recognize the recipient’s HLA antigens as being foreign
Recipient cells recognize the donor’s HLA antigens as being foreign
Anti-recipient CD4+ and CD8+ T cells are generated
Epithelia of skin, liver and intestine are affected
Secondary cytomegalovirus infection may be occur
ANSWER = B
77.
Birefringence of amyloid deposits can be enhanced by polarizing microscopy in
tissues stained with
a.
b.
c.
d.
e.
ANSWER = D
Trichrome Masson stain
Hematoxylin & Eosin stain
Lugol’s iodine stain
Congo red stain
Periodic Acid Schiff (PAS) stain
78.
Restriction-fragment-length polymorphism (RFLP) would be helpful to determine the
genetic abnormalities in which one of the following amyloid fibrillary protein?
a.
b.
c.
d.
e.
Immunoglobulin light chains
Serum amyloid associated protein
2-microglobulin
Calcitonin
Transthyretin
ANSWER = E
79.
Which one of the following autoantibodies is seen in patients with megaloblastic
anemia?
a.
b.
c.
d.
e.
Anti-tRNA synthetase antibody
Anti-gastric parietal cell antibody
Anti-DNA antibody
Anti-microperoxidase antibody
Anti-erythrocyte antibody
ANSWER = B
80.
Which one of the following is true of pernicious anemia?
a.
b.
c.
d.
e.
Anemia is due to the deficiency Vitamin B6
Patients present with increased secretion of hydrochloric acid
Anemia is due to the hemolysis of RBCs
Gastric mucosa lacks parietal epithelial cells
Hemoglobin synthesis is abnormal
ANSWER = D
81.
Which one of the following diseases may not associated with any respiratory
difficulties?
a.
b.
c.
d.
e.
Myasthenia gravis
Scleroderma
Graves disease
Wegener’s granulomatosis
Asthma
ANSWER = C
82.
Which one of the following may not be the feature of Reiter’s syndrome?
a.
b.
c.
d.
e.
Arthritis
Myocarditis
Urethritis
Conjunctivitis
Cervicitis
ANSWER = B
83.
Which of following diseases may be associated with reactive systemic amyloidosis?
a.
b.
c.
d.
e.
ANSWER = E
Pulmonary tuberculosis
Ankylosing spondylitis
Rheumatoid arthritis
Regional enteritis
All of the above
Matching format questions. Please be kind to search the answers in your notes and text books also.
84.
A.
B.
C.
D.
E.
T-Cells
B-Cells
Natural Killer Cells
Macrophage/monocyte
Killer Cells
D.
C.
A.
E.
B.
produce interleukin-1
express Fc receptors
produce interleukin-2
immune surveillance
express Fc & C3b receptors
85.
A.
B.
C.
D.
Interleukin-2
Interleukin-1
Gamma interferon
Tumor necrosis factor alpha
B.
A.
D.
C.
activates the resting T cells
rapidly activates Natural Killer cells
induces acute phase reactions
antiviral activity
86.
A.
B.
C.
D.
Class I antigens
Class II antigens
Class III antigens
T-cell receptor antigens
B.
C.
D.
A.
activation of helper cells
encode for certain complement proteins
regulate antigen recognition events
regulate functions of cytotoxic cells
87.
A.
B.
C.
D.
Type-I hypersensitivity
Type-II hypersensitivity
Type-III hypersensitivity
Type-IV hypersensitivity
C.
A.
D.
B.
activation of Hageman factor
phosphorylation of granular membrane
MHC class I restricted cytotoxicity
antibody dependent cellular cytotoxicity
88.
A.
B.
C.
D.
Type-I hypersensitivity
Type-II hypersensitivity
Type-III hypersensitivity
Type-IV hypersensitivity
C.
A.
D.
B.
antigen-antibody complexes
cytophilic antibody
lymphotoxins (TNF-)
cytotoxic antibody
89.
A.
B.
C.
D.
Type-I hypersensitivity
Type-II hypersensitivity
Type-III hypersensitivity
Type-IV hypersensitivity
C.
B.
D.
A.
Arthus reaction
erythroblastosis fetalis
Mantoux reaction
allergic rhinitis
90.
A.
B.
C.
D.
E.
Hashimoto's disease
Grave's disease
Myasthenia Gravis
Goodpasture's syndrome
Pernicious anemia
B.
D.
E.
C.
A.
anti-TSH antibody
anti-type IV collagen (NC1) antibody
anti-gastric parietal cell antibody
anti-acetylcholine receptor antibody
anti-thyroglobulin antibody
91.
A.
B.
C.
D.
E.
Hashimoto's disease
Grave's disease
Myasthenia Gravis
Goodpasture's syndrome
Pernicious anemia
B.
D.
A.
E.
C.
hyperactivity of thyroid cells
crescentic glomerulonephritis
presence of Hurthle cells
subacute combined myelin degeneration
myofiber atrophy
92.
A.
B.
C.
D.
Anti-dsDNA
Anti-histone
Anti-RNP
Anti-HBsAg
B.
D.
C.
A.
drug-induced lupus erythematosus
polyarteritis nodosa
mixed connective tissue disorders
systemic lupus erythematosus
93.
A.
B.
C.
D.
Anti-tRNA synthetase
Anti-DNA topoisomerase
Anti-SSb
Anti-centromere
D.
A.
B.
C.
CREST syndrome
Polymyositis/dermatositis
diffuse systemic sclerosis
Sjogren's syndrome
94.
A.
B.
C.
D.
E.
Systemic lupus erythematosus
Drug-induced lupus
Mixed connective tissue disorders
Progressive systemic sclerosis
Sjogren's syndrome
C.
E.
D.
B.
A.
overlapping clinical features
dryness of mucous membranes
claw-like deformities
slow-acetylators
Libman-Sacks endocarditis
95.
A.
B.
C.
D.
E.
Lupus nephritis, diffuse
Lupus nephritis, membranous
Polyarteritis nodosa
Progressive systemic sclerosis
Sjogren's syndrome
D.
B.
E.
A.
C.
honeycomb appearance of the lung
nephrotic syndrome
high incidence of B-cell lymphoma
low levels of complement
aneurysmal dilatation of blood vessels
96.
A.
B.
C.
D.
E.
Bruton's agammaglobulinemia
DiGeorge Syndrome
Transcobalamin II deficiency
HIV infection
Adenosine deaminase deficiency
D.
E.
A.
B.
C.
defective cell-mediated immunity
toxicity of T- & B-Cells
defective humoral immunity
defective 3rd & 4th pharyngeal pouches
pancytopenia
97.
A.
B.
C.
D.
E.
Amyloid light chain
-amyloid protein A4
Amyloid-P
-2 amyloid microglobulin
Transthyretin
E.
C.
A.
B.
D.
familial neuropathic form of amyloidosis
homologous to C-reactive protein
multiple myeloma
Alzheimer's disease
associated with long-term hemodialysis
98.
A.
B.
C.
D.
E.
Coomb's test
Farr's immunoassay
Raji cell assay
Western Blot assay
Flow cytometry
C.
A.
E.
B.
D.
measures circulating immune complexes
used for autoimmune hemolytic anemia
determines the ratio of CD4:CD8-T cells
measures anti-dsDNA
detects the presence of anti-gp120 & -gp41
99.
A.
B.
C.
D.
E.
Interleukin-1
-interferon
TNF-
Interleukin-2
Perforin
D.
A.
E.
B.
C.
made by activated T cells
made by virtually every cell
made by cytotoxic T cell
has antiviral activity
induces fever
100.
A.
B.
C.
D.
E.
Hay fever
Erythroblastosis fetalis
Arthus reaction
Graft-versus-host disease
Intractable arrhythmia
C.
E.
D.
A.
B.
type-III hypersensitivity reaction
Amyloidosis
type-IV hypersensitivity reaction
type-I hypersensitivity reaction
type-II hypersensitivity reaction