Download Role of blood and synovial fluid inflammatory markers in ARMD

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Role of blood and synovial fluid inflammatory markers in ARMD
diagnostics of patients with MoM hip replacements
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Cobolt (Co) and chromium (Cr) induced adverse reactions to metal debris (ARMD) are common
phenomena in metal-on-metal (MoM) hip arthroplasty. In this study we investigated the correlation of
blood and synovial fluid inflammatory markers with macro- and microscopic findings in ARMD, patients’
symptoms, and synovial fluid and blood Co and Cr levels in a cohort of 196 MoM patients revised for
ARMD at our institution. No significant correlation was found with any of the tested parameters. Over
90 % of the inflammatory markers were at normal range. In conclusion, inflammatory markers do not
seem to have diagnostic value in evaluating the severity of ARMD. Instead, they are useful in
differential diagnostics between prosthetic joint infection and ARMD.