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Patterns of DNA fragments seen after PCR amplification using primers shown in Fig. 162-11 followed by digestion with SmaI, gel electrophoresis, and ethidium bromide staining. Lanes 3, 6, and 7 show results obtained from DNA of individuals homozygous for the deletion that is illustrated in Fig. 162-11 while 2, 4, and 5 are heterozygous and 1 and 8 to 12 are homozygous for the absence of this deletion.126 Source: Inherited Defects in Growth Hormone Synthesis and Action, The Online Metabolic and Molecular Bases of Inherited Disease Citation: Valle D, Beaudet AL, Vogelstein B, Kinzler KW, Antonarakis SE, Ballabio A, Gibson K, Mitchell G. The Online Metabolic and Molecular Bases of Inherited Disease; 2014 Available at: http://mhmedical.com/ Accessed: August 11, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved