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Transcript
Structural basis for quinine-dependent antibody binding to
platelet integrin αIIbβ3
by Jianghai Zhu, Jieqing Zhu, Daniel W. Bougie, Richard H. Aster, and Timothy A.
Springer
Blood
Volume 126(18):2138-2145
October 29, 2015
©2015 by American Society of Hematology
Alignment of 314.1 and 314.3 V domains and corresponding germline sequences.
Jianghai Zhu et al. Blood 2015;126:2138-2145
©2015 by American Society of Hematology
Crystal structures of Fabs 314.1 and 314.3 and their complexes with quinine.
Jianghai Zhu et al. Blood 2015;126:2138-2145
©2015 by American Society of Hematology
Details of quinine binding.
Jianghai Zhu et al. Blood 2015;126:2138-2145
©2015 by American Society of Hematology
Quinine-Fab binding.
Jianghai Zhu et al. Blood 2015;126:2138-2145
©2015 by American Society of Hematology
Models for DDAb binding to a cell-surface molecule.
Jianghai Zhu et al. Blood 2015;126:2138-2145
©2015 by American Society of Hematology