Download Chapter 11 LT

Learning Targets Chapter 11: Cell Signaling
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I can summarize what is occurring in the three stages of cell communication: reception,
transduction and response.
I can distinguish between hydrophilic and hydrophobic ligands and identify where the
receptors for each type are located.
I can describe how the following receive cell signals and start transduction:
G-protein coupled receptors
tyrosine kinase receptors
ion channels
I can identify and describe the role of second messengers such as cyclic AMP and Ca2+
I can describe how a cell signal is amplified by a phosphorylation cascade.
I can describe how a cellular response in the nucleus differs from a cellular response in
the cytoplasm.
I can explain what apoptosis means and why it is important for normal functioning of
multicellular organisms.
Video:
http://www.bozemanscience.com/036-evolutinary-significance-of-cell-communication
Bozeman Cell communication http://www.bozemanscience.com/037-cell-communication
Bozeman Signal Transduction Pathways http://www.bozemanscience.com/038-signaltransduction-pathways
Bozeman Effect of Changes in the Pathways http://www.bozemanscience.com/039-effects-ofchanges-in-pathways
Extra link:
Prezi on Cell signaling
POGIL Cell communication
Quorum Sensing:
Bonnie Bassler on TED
Finish reflection from Bassler video:
What 2 important ideas did you learn from the work that Bassler is doing with regard to quorum
sensing in bacteria? Explain why each of these ideas are important and relevant.
Focus questions:
1. Why do cells need to communicate?
2. Explain what happens during the three phases of signal transduction.
3. What is the purpose of second messengers?
4. Diagram the epinephrine signaling pathway. Diagram signal reception, transduction and
response.
5. Define each of the following phenomena, identify the organisms that they occur in, and
explain how cellular signaling is used in each of them:
 Quorum Sensing
 Apoptosis
6.
Why do you think cellular signaling pathways and mechanisms are so universal among
life’s domains?
7. The similarities and differences in G-Protein, Tyrosine Kinase, and ligand-gated ion
channel signaling pathways.
8. How does a signaling pathway lead to an amplification of the response to the signal.
9. How can a signaling pathway have multiple physiological effects on a cell or organism?