Download Peak @ 1h Duration 4-8h Plasma Half

PO,PR,SYRUP,IV
-WorksbyinhibitingtheCOX(cyclooxyrgenase)enzymes,whichconvertarachidonicacidtoprostaglandinH2(PGH2).
-PGH2,isconvertedtoseveralotherprostaglandins(whicharemediatorsofpain,inflammation,andfever)
-AlsoconvertedtothromboxaneA2whichstimulatesplateletaggregation,leadingtotheformationofbloodclots.
-Non-selectiveCOXinhibitionof1&2.
-Antipyreticeffectsmaybeduetoactiononthehypothalamus=increasedperipheralbloodflow,vasodilation,andheatdissipation
-InhibitionofCOX-1isthoughttocausetheS/Eofgastrointestinalulceration.
-Ibuprofenisadministeredasaracemicmixture.TheS-enantiomer=morepharmacologicallyactive.
30-60minonset
Peak@1h
Duration4-8h
PlasmaHalf-life=2h
99%proteinbound
HepaticOxidation
Thereisananalgesicceilingdoseof400mg(1200mgdaily)
(i.e:600mgwillnotconferadditionalANALGESIAperdose)
Urineexcretion(asA&Binactivemetabolites)
DOSE-ADULTandCHILDover12years,300–400mg3–4timesdaily;increasedif
necessarytomax.2.4gdaily;maintenanceof0.6–1.2gdailymaybeadequate
Adverseeffectsinclude:
Nausea,dyspepsia,diarrhea,constipation,gastrointestinalulceration/bleeding,
headache,dizziness,rash,saltandfluidretention,andhypertension.
Infrequentadverseeffectsincludeoesophagealulceration,heartfailure,
hyperkalemia,renalimpairment,confusion,andbronchospasm.
CanbeusedtocloseaPDAinaneonate!
Ibuprofencanexacerbateasthma,sometimesfatally.
*https://dx.doi.org/10.1136%2Febnurs-2011-100439
*http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956584/
http://www.drugs.com/ppa/ibuprofen.html