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1 Genome-wide pharmacogenetic investigation of a hepatic adverse event without clinical signs of immunopathology suggests an underlying immune pathogenesis Supplementary note 1. The highest-ranking SNP (rs2858869) in Phase 1 of EXGEN was not included in the set of 250,000 tag SNPs selected for the GWS. Hence, if DRB1 had not been included as a candidate gene, the highest-ranking SNP in the HLA region from the tag SNP set would have been rs707937 (p=1.95 x 10-4), which is 14kb from VARS2 and 841kb from rs2858869. According to the strategy followed in this study, this SNP did not meet the threshold for follow-up (p10-5) and hence was not selected for further study. If, however, we had followed only a GWS strategy using these tag SNPs, this and other SNPs in the MHC class II region would have been among the top-ranked 650 associations, and hence would likely have been carried forward for subsequent fine mapping. The increased density of SNPs across the MHC region would then have uncovered the primary association with the DRB1 and DQA1 genes. Similarly, if the GWS and candidate gene study results had been combined and analysed together, the rs2858869 SNP would still have been among the highest-ranked and would have been carried forward for further fine mapping studies. It is likely, however, that the FDR and other analyses may not have been as clear-cut, with the signal-to-noise ratio being lower in the combined SNP set. We conclude that the details of our analysis strategy were not vital in discovering the primary association with the DRB1 and DQA1 genes, and that alternative strategies would likely have resulted in the same discovery. We do recommend, however, that a dense map of markers be used for initial screening (particularly in gene-dense areas like the HLA region) and that fine mapping with an increased density of markers be carried out in the same sample set, before selection of the highest-ranked markers for replication testing in an independent sample set. 2 Supplementary table 1 Patient population and disposition for EXGEN Cases N=78 Controls N=131 Intermediate N=39 Total N=248 73 1 36 5 16 24 5 3 0 7 142 9 55 8 34 130 a 130 (99%) 131 39 39 (100) 39 243 243 (98%) 248 70 (25 to 88) 77.2(54 to 110) 78 (60) 52 (40) 130 (100) 69 (57 to 87) 78.8(62 to 110) 24 (62) 15 (38) 39 (100) 70 (25 to 89) 76.6(50 to 110) 140 (58) 103 (42) 243 (100) 0.4 (0.2) 0.6 (0.4) 0.5 (0.3) 0.6 (0.2) 1.5 (0.6) 2.7 (3.7) Study SPORTIF III 45 SPORTIF IV 3 ESTEEM 16 THRIVE II 3 THRIVE III 11 Disposition Total 74a N (%) of subjects who completed 74 (95%) Safety population 78 Demographic and baseline characteristicsb Age (years) Mean (range) 71 (25 to 89) Weight (kg) Mean (range) 74.2(50 to 107) Sex (n (%) of Male 38 (51) subjects) Female 36 (49) Race (n (%) of Caucasian 74 (100) subjects) Baseline (preMean (SD) 0.5 (0.3) treatment) ALAT (xULN) Maximum ALAT Mean (SD) 7.1 (4.1) (xULN) 3 Supplementary table 2. Patient population used for the LTT study Groups and numbers Group 1 Ximelagatran exposed individuals who discontinued treatment at ALAT>4xULN Group 2 Ximelagatran exposed individuals who continued treatment at ALAT>4xULN N=13 N=8 Group 3 Ximelagatran exposed individuals with ALAT<1xULN and not exceeding 2x baseline value N=21 Group 4 Test subjects not exposed to ximelagatran N=10 Subjects (cases and matched controls) were preselected from previous long-term treatment studies with ximelagatran: ESTEEM, SPORTIF III, THRIVE III and THRIVE Treatment. The subjects were selected from clinical databases by AstraZeneca. The study was carried out in centres in Sweden. Subjects who had not previously taken part in EXGEN (10 cases from groups 1 & 2 and 16 controls from group 3) were used for replication testing. 4 Supplementary Table 3. 690 candidate genes selected on the basis of (i) the mechanism of ximelagatran, (ii) reported association with elevated liver enzymes and (iii) additional preclinical studies. SNPs were selected for each gene (defined by NCBI build 35), and 10kb flanking sequence. A sliding window approach was used to pick SNPs at a spacing of approximately 6 SNPs every 10kb (a total of 26,613 SNPs). Official Symbol A1BG AASS AATF ABCA1 ABCA10 ABCA12 ABCA13 ABCA2 ABCA3 ABCA4 ABCA5 ABCA6 ABCA7 ABCA8 ABCA9 ABCB1 ABCB10 ABCB11 ABCB4 ABCB5 ABCB6 ABCB7 ABCB8 ABCB9 ABCC1 ABCC10 ABCC11 ABCC12 ABCC13 ABCC2 ABCC3 ABCC4 ABCC5 ABCC6 ABCC8 ABCC9 ABCD1 Gene Name alpha-1-B glycoprotein; zinc finger protein 497 aminoadipate-semialdehyde synthase apoptosis antagonizing transcription factor ATP-binding cassette, sub-family A (ABC1), member 1 ATP-binding cassette, sub-family A (ABC1), member 10 ATP-binding cassette, sub-family A (ABC1), member 12 ATP binding cassette gene, sub-family A (ABC1), member 13 ATP-binding cassette, sub-family A (ABC1), member 2 ATP-binding cassette, sub-family A (ABC1), member 3 ATP-binding cassette, sub-family A (ABC1), member 4 ATP-binding cassette, sub-family A (ABC1), member 5 ATP-binding cassette, sub-family A (ABC1), member 6 ATP-binding cassette, sub-family A (ABC1), member 7 ATP-binding cassette, sub-family A (ABC1), member 8 ATP-binding cassette, sub-family A (ABC1), member 9 ATP-binding cassette, sub-family B (MDR/TAP), member 1 ATP-binding cassette, sub-family B (MDR/TAP), member 10 ATP-binding cassette, sub-family B (MDR/TAP), member 11 ATP-binding cassette, sub-family B (MDR/TAP), member 4 ATP-binding cassette, sub-family B (MDR/TAP), member 5 ATP-binding cassette, sub-family B (MDR/TAP), member 6 ATP-binding cassette, sub-family B (MDR/TAP), member 7 ATP-binding cassette, sub-family B (MDR/TAP), member 8; amiloride-sensitive cation channel 3 ATP-binding cassette, sub-family B (MDR/TAP), member 9 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 ATP-binding cassette, sub-family C (CFTR/MRP), member 10 ATP-binding cassette, sub-family C (CFTR/MRP), member 11 ATP-binding cassette, sub-family C (CFTR/MRP), member 12 ATP-binding cassette, sub-family C (CFTR/MRP), member 13 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 ATP-binding cassette, sub-family D (ALD), member 1 5 ABCD2 ABCD3 ABCD4 ABCE1 ABCF1 ABCF2 ABCF3 ABCG1 ABCG2 ABCG4 ABCG5 ABCG8 ACAA2 ACACA ACAT1 ACAT2 ACATE2 ACDC ACE ACF ACHE ACLY ACOX1 ACOX2 ACOX3 ACSL1 ADIPOR1 ADIPOR2 ADRA1A AF1Q AGT AKR1B10 ALDH1A1 ALDH1A2 ALDH1A3 ALDH1B1 ALDH2 ALDH3A1 ALDH3A2 ALDH3B1 ALDH3B2 ALDH4A1 ALDH5A1 ALDH6A1 ATP-binding cassette, sub-family D (ALD), member 2 ATP-binding cassette, sub-family D (ALD), member 3 ATP-binding cassette, sub-family D (ALD), member 4 ATP-binding cassette, sub-family E (OABP), member 1 ATP-binding cassette, sub-family F (GCN20), member 1 ATP-binding cassette, sub-family F (GCN20), member 2 ATP-binding cassette, sub-family F (GCN20), member 3 ATP-binding cassette, sub-family G (WHITE), member 1 ATP-binding cassette, sub-family G (WHITE), member 2 ATP-binding cassette, sub-family G (WHITE), member 4 ATP-binding cassette, sub-family G (WHITE), member 5 (sterolin 1) ATP-binding cassette, sub-family G (WHITE), member 8 (sterolin 2) acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase) acetyl-Coenzyme A carboxylase alpha acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase) likely ortholog of mouse acyl-Coenzyme A thioesterase 2, mitochondrial adipocyte, C1Q and collagen domain containing angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 apobec-1 complementation factor acetylcholinesterase (YT blood group) ATP citrate lyase acyl-Coenzyme A oxidase 1, palmitoyl acyl-Coenzyme A oxidase 2, branched chain acyl-Coenzyme A oxidase 3, pristanoyl acyl-CoA synthetase long-chain family member 1 adiponectin receptor 1 adiponectin receptor 2 adrenergic, alpha-1A-, receptor ALL1-fused gene from chromosome 1q angiotensinogen (serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 8) aldo-keto reductase family 1, member B10 (aldose reductase) aldehyde dehydrogenase 1 family, member A1 aldehyde dehydrogenase 1 family, member A2 aldehyde dehydrogenase 1 family, member A3 aldehyde dehydrogenase 1 family, member B1 aldehyde dehydrogenase 2 family (mitochondrial) aldehyde dehydrogenase 3 family, memberA1 aldehyde dehydrogenase 3 family, member A2 aldehyde dehydrogenase 3 family, member B1 aldehyde dehydrogenase 3 family, member B2 aldehyde dehydrogenase 4 family, member A1 aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase) aldehyde dehydrogenase 6 family, member A1 6 ALDH7A1 ALDH8A1 ALDH9A1 ANGPTL4 ANKRD28 APBA1 APOA1 APOA2 APOB APOBEC1 APOC2; APOC4 APOC3 APOE AREG ARMET ARNT ARNT2 ASB13 ASL aldehyde dehydrogenase 7 family, member A1 aldehyde dehydrogenase 8 family, member A1 aldehyde dehydrogenase 9 family, member A1 angiopoietin-like 4 ankyrin repeat domain 28 amyloid beta (A4) precursor protein-binding, family A, member 1 (X11) apolipoprotein A-I apolipoprotein A-II apolipoprotein B (including Ag(x) antigen) apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 apolipoprotein C-II; apolipoprotein C-IV apolipoprotein C-III apolipoprotein E amphiregulin (schwannoma-derived growth factor) arginine-rich, mutated in early stage tumors aryl hydrocarbon receptor nuclear translocator aryl-hydrocarbon receptor nuclear translocator 2 ankyrin repeat and SOCS box-containing 13 argininosuccinate lyase butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine BBOX1 hydroxylase) 1 BCHE butyrylcholinesterase branched chain keto acid dehydrogenase E1, beta polypeptide (maple syrup BCKDHB urine disease) BHLHB2 basic helix-loop-helix domain containing, class B, 2 BHMT betaine-homocysteine methyltransferase BLNK B-cell linker BMP2 bone morphogenetic protein 2 BTC betacellulin BTEB1 basic transcription element binding protein 1 CAMK2G; calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma; NNDST2 deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 CARM1 coactivator-associated arginine methyltransferase 1 CAT catalase CCL2 chemokine (C-C motif) ligand 2 CCNG1 cyclin G1 CD109 CD109 antigen (Gov platelet alloantigens) CD44 CD44 antigen (homing function and Indian blood group system) CDO1 cysteine dioxygenase, type I CDT6 angiopoietin-like factor CEP57 translokin Cep70 p10-binding protein cystic fibrosis transmembrane conductance regulator, ATP-binding cassette CFTR (sub-family C, member 7) CHN2 chimerin (chimaerin) 2 CLYBL citrate lyase beta like 7 CML2 COBLL1 COMT COQ3 COQ4 COQ6 COQ7 CORIN CPT2 CREB3L2 CRYAA CSF1 CUTL2 CYB5 CYB5R2 CYP1A1 CYP1A2 CYP1B1 CYP2A6 CYP2B6 CYP2C19; CYP2C18 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP39A1 CYP3A4 CYP3A5; CYP3A5P2 CYP4A11; CYP4A22 CYP51A1 CYP7A1 CYR61 DDT DECR1 DEPDC7 DHCR7 DIA1 DIO1 DNMT1 DNMT2 DNMT3A DNMT3B DOC1 putative N-acetyltransferase Camello 2 COBL-like 1 catechol-O-methyltransferase coenzyme Q3 homolog, methyltransferase (yeast) coenzyme Q4 homolog (yeast) coenzyme Q6 homolog (yeast) coenzyme Q7 homolog, ubiquinone (yeast) corin, serine protease carnitine palmitoyltransferase II cAMP responsive element binding protein 3-like 2 crystallin, alpha A colony stimulating factor 1 (macrophage) cut-like 2 (Drosophila) cytochrome b-5 cytochrome b5 reductase b5R.2 cytochrome P450, family 1, subfamily A, polypeptide 1 cytochrome P450, family 1, subfamily A, polypeptide 2 cytochrome P450, family 1, subfamily B, polypeptide 1 cytochrome P450, family 2, subfamily A, polypeptide 6; egl nine homolog 2 (C. elegans) cytochrome P450, family 2, subfamily B, polypeptide 6 cytochrome P450, family 2, subfamily C, polypeptide 19; cytochrome P450, family 2, subfamily C, polypeptide 18 cytochrome P450, family 2, subfamily C, polypeptide 8 cytochrome P450, family 2, subfamily C, polypeptide 9 cytochrome P450, family 2, subfamily D, polypeptide 6 cytochrome P450, family 2, subfamily E, polypeptide 1 cytochrome P450, family 39, subfamily A, polypeptide 1 cytochrome P450, family 3, subfamily A, polypeptide 4 cytochrome P450, family 3, subfamily A, polypeptide 5; cytochrome P450, family 3, subfamily A, polypeptide 5 pseudogene 2 cytochrome P450, family 4, subfamily A, polypeptide 11; cytochrome P450, family 4, subfamily A, polypeptide 22 cytochrome P450, family 51, subfamily A, polypeptide 1 cytochrome P450, family 7, subfamily A, polypeptide 1 cysteine-rich, angiogenic inducer, 61 D-dopachrome tautomerase 2,4-dienoyl CoA reductase 1, mitochondrial novel 58.3 KDA protein 7-dehydrocholesterol reductase diaphorase (NADH) (cytochrome b-5 reductase) deiodinase, iodothyronine, type I DNA (cytosine-5-)-methyltransferase 1 DNA (cytosine-5-)-methyltransferase 2 DNA (cytosine-5-)-methyltransferase 3 alpha DNA (cytosine-5-)-methyltransferase 3 beta downregulated in ovarian cancer 1 8 DOC-1R DPP4 DPYD DSIPI DTR ECHS1 EEF1A2 EGF EGFR EI24 ELA2 ELOVL6 ELOVL6 EMP2 EPHX1 tumor suppressor deleted in oral cancer-related 1 dipeptidylpeptidase 4 (CD26, adenosine deaminase complexing protein 2) dihydropyrimidine dehydrogenase delta sleep inducing peptide, immunoreactor diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor) enoyl Coenzyme A hydratase, short chain, 1, mitochondrial eukaryotic translation elongation factor 1 alpha 2 epidermal growth factor (beta-urogastrone) epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) etoposide induced 2.4 mRNA elastase 2, neutrophil ELOVL family member 6, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast) epithelial membrane protein 2 epoxide hydrolase 1, microsomal (xenobiotic) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma ERBB2 derived oncogene homolog (avian); chromosome 17 open reading frame 37 protein disulfide isomerase related protein (calcium-binding protein, intestinalERP70 related) ETFDH electron-transferring-flavoprotein dehydrogenase F10 coagulation factor X F11 coagulation factor XI (plasma thromboplastin antecedent) F2 coagulation factor II (thrombin) F2R coagulation factor II (thrombin) receptor F5 coagulation factor V (proaccelerin, labile factor) F7 coagulation factor VII (serum prothrombin conversion accelerator) F8 coagulation factor VIII, procoagulant component (hemophilia A) coagulation factor IX (plasma thromboplastic component, Christmas disease, F9 hemophilia B) fatty acid binding protein 5 (psoriasis-associated); fatty acid binding protein 5-like 3; similar to Fatty acid-binding protein, epidermal (E-FABP) (Psoriasis-associated FABP5 fatty acid-binding protein homolog) (PA-FABP) FADS1 fatty acid desaturase 1 FADS2 fatty acid desaturase 2 FADS3 fatty acid desaturase 3 FAM13A1 family with sequence similarity 13, member A1 FAM34A family with sequence similarity 34, member A FAM46C family with sequence similarity 46, member C FASN fatty acid synthase FDFT1 farnesyl-diphosphate farnesyltransferase 1 farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, FDPS dimethylallyltranstransferase, geranyltranstransferase) FGF13 fibroblast growth factor 13 FGF2 fibroblast growth factor 2 (basic) FGF21 fibroblast growth factor 21 9 FGF23 fibroblast growth factor 23 fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer FGFR2 syndrome, Jackson-Weiss syndrome) FKBP5 FK506 binding protein 5; hypothetical protein LOC285847 FLJ14981 hypothetical protein FLJ14981 FLJ20701 hypothetical protein FLJ20701 FLRT3 fibronectin leucine rich transmembrane protein 3 FOXO3A forkhead box O3A FRZB frizzled-related protein FTHFD formyltetrahydrofolate dehydrogenase FXN frataxin G6PD glucose-6-phosphate dehydrogenase GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1; ubiquitin D GAMT guanidinoacetate N-methyltransferase GARS glycyl-tRNA synthetase GAS2 growth arrest-specific 2 GFPT1 glutamine-fructose-6-phosphate transaminase 1 GGPS1 geranylgeranyl diphosphate synthase 1 GHR growth hormone receptor GLCE glucuronyl C5-epimerase GLUL glutamate-ammonia ligase (glutamine synthase) GLYAT glycine-N-acyltransferase GNMT glycine N-methyltransferase GNS glucosamine (N-acetyl)-6-sulfatase (Sanfilippo disease IIID) GOT1 glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1) GPAM glycerol-3-phosphate acyltransferase, mitochondrial GPHN gephyrin G protein-coupled receptor 125; similar to single stranded DNA binding protein 4; GPR125 dispatched homolog 2 (Drosophila) GPR177 putative NFkB activating protein 373 GPRC5B G protein-coupled receptor, family C, group 5, member B GPT glutamic-pyruvate transaminase (alanine aminotransferase) GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 GPX1 glutathione peroxidase 1 GPX2 glutathione peroxidase 2 (gastrointestinal) GPX3 glutathione peroxidase 3 (plasma) GPX4 glutathione peroxidase 4 (phospholipid hydroperoxidase) GPX5 glutathione peroxidase 5 (epididymal androgen-related protein) GPX6 glutathione peroxidase 6 (olfactory) GPX7 glutathione peroxidase 7 GPXP2 GSN gelsolin (amyloidosis, Finnish type) GSR glutathione reductase GSS glutathione synthetase GSTA2 glutathione S-transferase A2 GSTA3 glutathione S-transferase A3 10 GSTA4 GSTA5 GSTK1 GSTM1 GSTM3 GSTM5 GSTO1 GSTO2 GSTP1 GSTT1 GSTT2 GSTZ1 GYS1 GYS2 GZMK glutathione S-transferase A4 glutathione S-transferase A5 glutathione S-transferase kappa 1 glutathione S-transferase M2 (muscle); glutathione S-transferase M4; glutathione S-transferase M1 glutathione S-transferase M3 (brain) glutathione S-transferase M5 glutathione S-transferase omega 1 glutathione S-transferase omega 2 glutathione S-transferase pi glutathione S-transferase theta 1 glutathione S-transferase theta 2 glutathione transferase zeta 1 (maleylacetoacetate isomerase) glycogen synthase 1 (muscle) glycogen synthase 2 (liver) granzyme K (serine protease, granzyme 3; tryptase II) hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit hepatocellular carcinoma-associated antigen 112 chromosome 14 open reading frame 68 hemochromatosis hepatocyte growth factor (hepapoietin A; scatter factor) hypothetical protein FLJ22761 major histocompatibility complex, class I, A major histocompatibility complex, class I, B; major histocompatibility complex, class I, C HADHA HCA112 HDMCP HFE HGF HKDC1 HLA-A HLA-B; HLA-C HLA-DRB1; HLA-DRB3; HLA-DRB5; HLA-DRB2; HLA-DQB1; major histocompatibility complex, class II, DR beta 1; major histocompatibility HLA-DQB2; complex, class II, DR beta 3; major histocompatibility complex, class II, DR beta HLA-DRB4; 5; major histocompatibility complex, class II, DR beta 2; major histocompatibility HLA-DRB6 complex, c HLA-DRB5 major histocompatibility complex, class II, DR beta 5 HLF hepatic leukemia factor HMBS hydroxymethylbilane synthase 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase HMGCL (hydroxymethylglutaricaciduria) HMGCR 3-hydroxy-3-methylglutaryl-Coenzyme A reductase HMGCS1 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) HMGCS2 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial) HNF4A hepatocyte nuclear factor 4, alpha; hypothetical protein FLJ39654 HPN hepsin (transmembrane protease, serine 1) HRIHFB21 22 Tara-like protein HS2ST1 heparan sulfate 2-O-sulfotransferase 1; hypothetical protein LOC339524 HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1 11 HS3ST2 HS3ST3B1 HS3ST4 HS3ST5 HS6ST1 HS6ST2 HS6ST3 HSPA5 HSPC280 HTRA3 HYAL1 HYOU1 ICMT ID1 IDH2 IDI1 IER3 IFNG IGF1 IGF1R IGF2 IGF2R IGFBP3 IGFBP4 IL17RB IL1A IL1B IL6 INMT INSR IRS1 IRS2 IRS4 JUB KAZALD1 KCTD14 KDELR2 KDELR3 KIS KLB KLK1 KLK10 KLK11 KLK12 KLK13 heparan sulfate (glucosamine) 3-O-sulfotransferase 2 heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1 heparan sulfate (glucosamine) 3-O-sulfotransferase 4 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 heparan sulfate 6-O-sulfotransferase 1 heparan sulfate 6-O-sulfotransferase 2 heparan sulfate 6-O-sulfotransferase 3 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) chromosome 6 open reading frame 115 serine protease HTRA3 hyaluronoglucosaminidase 3; hyaluronoglucosaminidase 1; N-acetyltransferase 6 hypoxia up-regulated 1 isoprenylcysteine carboxyl methyltransferase inhibitor of DNA binding 1, dominant negative helix-loop-helix protein isocitrate dehydrogenase 2 (NADP+), mitochondrial isopentenyl-diphosphate delta isomerase immediate early response 3 interferon, gamma insulin-like growth factor 1 (somatomedin C) insulin-like growth factor 1 receptor insulin-like growth factor 2 (somatomedin A) insulin-like growth factor 2 receptor insulin-like growth factor binding protein 3 insulin-like growth factor binding protein 4 interleukin 17 receptor B interleukin 1, alpha interleukin 1, beta interleukin 6 (interferon, beta 2) indolethylamine N-methyltransferase insulin receptor insulin receptor substrate 1 insulin receptor substrate 2 insulin receptor substrate 4 jub, ajuba homolog (Xenopus laevis) Kazal-type serine protease inhibitor domain 1 potassium channel tetramerisation domain containing 14 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2; KCCR13L KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 kinase interacting with leukemia-associated gene (stathmin) klotho beta like kallikrein 1, renal/pancreas/salivary kallikrein 10 kallikrein 11 kallikrein 12 kallikrein 13 12 KLK14 KLK15 KLK2 KLK3 KLK4 KLK5 KLK6 KLK7; KLK8 KLK9 KLKB1 KRT8 LDLR LECT2 LGALS1 LGALS4 LIPC LIPG LOC12387 6 LOC14970 3 LOXL4 LPL LRRC8 LSS MAC30 MAFB MAGI1 MAN1C1 MANEA MAP2 MARCKS kallikrein 14 kallikrein 15 kallikrein 2, prostatic kallikrein 3, (prostate specific antigen) kallikrein 4 (prostase, enamel matrix, prostate) kallikrein 5 kallikrein 6 (neurosin, zyme) kallikrein 7 (chymotryptic, stratum corneum); kallikrein 8 (neuropsin/ovasin) kallikrein 9 kallikrein B, plasma (Fletcher factor) 1 keratin 8 low density lipoprotein receptor (familial hypercholesterolemia) leukocyte cell-derived chemotaxin 2 lectin, galactoside-binding, soluble, 1 (galectin 1) lectin, galactoside-binding, soluble, 4 (galectin 4) lipase, hepatic lipase, endothelial hypothetical protein LOC123876 hypothetical protein LOC149703 lysyl oxidase-like 4 lipoprotein lipase leucine rich repeat containing 8 lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) hypothetical protein MAC30 v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian) membrane associated guanylate kinase interacting protein-like 1 mannosidase, alpha, class 1C, member 1 mannosidase, endo-alpha microtubule-associated protein 2 myristoylated alanine-rich protein kinase C substrate mannan-binding lectin serine protease 1 (C4/C2 activating component of RaMASP1 reactive factor); mannan-binding lectin serine protease 1 pseudogene 1 MASP2 mannan-binding lectin serine protease 2 MBTPS1 membrane-bound transcription factor protease, site 1 membrane-bound transcription factor protease, site 2; hypothetical protein MBTPS2 LOC203411; YY2 transcription factor ME1 malic enzyme 1, NADP(+)-dependent, cytosolic ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial MEIS1 Meis1, myeloid ecotropic viral integration site 1 homolog (mouse) MFRP membrane frizzled-related protein MGC4083 tubulin beta MGC4083 MGC4677 hypothetical protein MGC4677 MGST1 microsomal glutathione S-transferase 1 13 MGST2 MGST3 MIG-6 MME MMP12 MSP MT1X MTP MTR MUSTN1 MVD MVK MYH9 MYO5B NAT1 NAT2 NAT5 NAT8 NCB5OR NCOA2 NDST1 NDST3 NDST4 NK4 NNMT NOS1 NQO1 NQO2 NR1H2 NR1H3 NR1I2 NR1I3 NR2F2 NR3C1 NUCB2 OAF OAT OSTalpha P11 PANK1 PAPSS2 PBX1 PCDH20 microsomal glutathione S-transferase 2 microsomal glutathione S-transferase 3 mitogen-inducible gene 6 membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10) matrix metalloproteinase 12 (macrophage elastase) mosaic serine protease metallothionein 1X microsomal triglyceride transfer protein (large polypeptide, 88kDa) 5-methyltetrahydrofolate-homocysteine methyltransferase; hypothetical protein LOC149448 musculoskeletal, embryonic nuclear protein 1; Similar to RIKEN cDNA 1810038N08 gene; inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein) mevalonate (diphospho) decarboxylase mevalonate kinase (mevalonic aciduria) myosin, heavy polypeptide 9, non-muscle myosin VB N-acetyltransferase 1 (arylamine N-acetyltransferase) N-acetyltransferase 2 (arylamine N-acetyltransferase) N-acetyltransferase 5 (ARD1 homolog, S. cerevisiae) N-acetyltransferase 8 (camello like) NADPH cytochrome B5 oxidoreductase nuclear receptor coactivator 2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 natural killer cell transcript 4 nicotinamide N-methyltransferase NAD(P)H dehydrogenase, quinone 1 NAD(P)H dehydrogenase, quinone 2 nuclear receptor subfamily 1, group H, member 2 nuclear receptor subfamily 1, group H, member 3 nuclear receptor subfamily 1, group I, member 2 nuclear receptor subfamily 1, group I, member 3 nuclear receptor subfamily 2, group F, member 2 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) nucleobindin 2 NS5ATP13TP2 protein ornithine aminotransferase (gyrate atrophy) organic solute transporter alpha 26 serine protease pantothenate kinase 1 3'-phosphoadenosine 5'-phosphosulfate synthase 2 pre-B-cell leukemia transcription factor 1 protocadherin 20 14 PCDH9 PCK1 PCMT1 PDE4DIP PDK4 PEG10 PF4 PGD; KIF1B PIK3R1 PKLR PKM2 PLA2G12A PLA2G2A PLAT PLAU PLAUR PLEK2 PLG PMM2 PMVK PNLIP PNMT PON1 POR PPARA PPARD PPARG PPIB PPP1R3C PR1 PRG2 PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 PRLR PRMT7 PRO1855 PROC PROCR PRSS1 PRSS11 protocadherin 9 phosphoenolpyruvate carboxykinase 1 (soluble) protein-L-isoaspartate (D-aspartate) O-methyltransferase phosphodiesterase 4D interacting protein (myomegalin) pyruvate dehydrogenase kinase, isoenzyme 4 paternally expressed 10 platelet factor 4 (chemokine (C-X-C motif) ligand 4) phosphogluconate dehydrogenase; kinesin family member 1B phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha) pyruvate kinase, liver and RBC pyruvate kinase, muscle phospholipase A2, group XIIA phospholipase A2, group IIA (platelets, synovial fluid) plasminogen activator, tissue plasminogen activator, urokinase plasminogen activator, urokinase receptor pleckstrin 2 plasminogen phosphomannomutase 2 phosphomevalonate kinase pancreatic lipase phenylethanolamine N-methyltransferase paraoxonase 1 P450 (cytochrome) oxidoreductase peroxisome proliferative activated receptor, alpha peroxisome proliferative activated receptor, delta peroxisome proliferative activated receptor, gamma peptidylprolyl isomerase B (cyclophilin B) protein phosphatase 1, regulatory (inhibitor) subunit 3C voltage-dependent calcium channel gamma subunit-like protein proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein); solute carrier family 43, member 3 protein kinase, AMP-activated, alpha 1 catalytic subunit protein kinase, AMP-activated, alpha 2 catalytic subunit protein kinase, AMP-activated, beta 1 non-catalytic subunit protein kinase, AMP-activated, beta 2 non-catalytic subunit protein kinase, AMP-activated, gamma 1 non-catalytic subunit protein kinase, AMP-activated, gamma 2 non-catalytic subunit protein kinase, AMP-activated, gamma 3 non-catalytic subunit prolactin receptor protein arginine N-methyltransferase 7 hypothetical protein PRO1855 protein C (inactivator of coagulation factors Va and VIIIa) protein C receptor, endothelial (EPCR) protease, serine, 1 (trypsin 1) protease, serine, 11 (IGF binding) 15 PRSS12 PRSS15 PRSS2 PRSS22 PRSS23 PRSS25 PRSS3 PRSS33 PRSS35 PRSS7 PSTPIP2 PTEN PTP4A1 PVRL2 PXMP2 RARA RARB RARG RBP1 RBP2 RBP3 RBP4 RBP5 RBP7 RDH5 REPS1 RETN RHOF RORA RORA RPESP RWDD3 RXRA RXRB RXRG SARA2 SC5DL SCAP SCARB1 SCD SCD4 SCDR10 SCDR9 SCGN SDC2 protease, serine, 12 (neurotrypsin, motopsin) protease, serine, 15 protease, serine, 2 (trypsin 2) protease, serine, 22 protease, serine, 23 protease, serine, 25 protease, serine, 3 (mesotrypsin) protease, serine, 33 protease, serine, 35 protease, serine, 7 (enterokinase) proline-serine-threonine phosphatase interacting protein 2 phosphatase and tensin homolog (mutated in multiple advanced cancers 1) protein tyrosine phosphatase type IVA, member 1 poliovirus receptor-related 2 (herpesvirus entry mediator B) peroxisomal membrane protein 2, 22kDa retinoic acid receptor, alpha retinoic acid receptor, beta retinoic acid receptor, gamma retinol binding protein 1, cellular retinol binding protein 2, cellular retinol binding protein 3, interstitial retinol binding protein 4, plasma retinol binding protein 5, cellular; complement component 1, r subcomponent; complement component 1, r subcomponent-like retinol binding protein 7, cellular retinol dehydrogenase 5 (11-cis and 9-cis); biogenesis of lysosome-related organelles complex-1, subunit 1 RALBP1 associated Eps domain containing 1 resistin ras homolog gene family, member F (in filopodia) RAR-related orphan receptor A RPE-spondin; hypothetical protein LOC286191 hypothetical protein FLJ31842 retinoid X receptor, alpha retinoid X receptor, beta retinoid X receptor, gamma SAR1a gene homolog 2 (S. cerevisiae) sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, fungal)-like SREBP CLEAVAGE-ACTIVATING PROTEIN scavenger receptor class B, member 1 stearoyl-CoA desaturase (delta-9-desaturase) stearoyl-CoA desaturase 4 short-chain dehydrogenase/reductase 10 short-chain dehydrogenase/reductase 9 secretagogin, EF-hand calcium binding protein syndecan 2 (heparan sulfate proteoglycan 1, cell surface-associated, fibroglycan) 16 SDCBP2 SEC61A1 SERPINA1 SERPINA1 0 SERPINA1 1 SERPINA1 2 SERPINA1 3 SERPINA2 SERPINA3 SERPINA4 SERPINA5 SERPINA6 SERPINA7 SERPINA9 SERPINB1 SERPINB1 0 SERPINB1 1 SERPINB1 2 SERPINB1 3 SERPINB2 SERPINB3 SERPINB4 SERPINB5 SERPINB6 SERPINB7 SERPINB8 SERPINB9 SERPINC1 SERPIND1 syndecan binding protein (syntenin) 2 Sec61 alpha 1 subunit (S. cerevisiae) serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 13 serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2 serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 1 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 10 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 11 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 12 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 13; UV-B repressed sequence, HUR 7 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 2 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 3 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 4 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 6 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 7 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 8 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 9 serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1 serine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member 1 serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator SERPINE1 inhibitor type 1), member 1 serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator SERPINE2 inhibitor type 1), member 2 serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment SERPINF1 epithelium derived factor), member 1 17 serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment SERPINF2 epithelium derived factor), member 2 serine (or cysteine) proteinase inhibitor, clade G (C1 inhibitor), member 1, SERPING1 (angioedema, hereditary) serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member SERPINH1 1, (collagen binding protein 1) SERPINI1 serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 1 SERPINI2 serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 2 SFN stratifin SFRP1 secreted frizzled-related protein 1 SFRP2 secreted frizzled-related protein 2 SFRP4 secreted frizzled-related protein 4 SFRP5 secreted frizzled-related protein 5 SHB SHB (Src homology 2 domain containing) adaptor protein B SIAT10 sialyltransferase 10 (alpha-2,3-sialyltransferase VI) SIPA1L2 signal-induced proliferation-associated 1 like 2 SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter family), member 1 SLC10A2 solute carrier family 10 (sodium/bile acid cotransporter family), member 2 SLC22A7 solute carrier family 22 (organic anion transporter), member 7 SLC22A8 solute carrier family 22 (organic anion transporter), member 8 SLC22A9 solute carrier family 22 (organic anion/cation transporter), member 9 SLC27A1 solute carrier family 27 (fatty acid transporter), member 1 SLC27A2 solute carrier family 27 (fatty acid transporter), member 2 SLC27A5 solute carrier family 27 (fatty acid transporter), member 5 SLC29A1 solute carrier family 29 (nucleoside transporters), member 1 SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 SLC35C1 solute carrier family 35, member C1 SLC38A4 solute carrier family 38, member 4 SLCO1A2 solute carrier organic anion transporter family, member 1A2 SLCO1B1 solute carrier organic anion transporter family, member 1B1 SLCO1B3 solute carrier organic anion transporter family, member 1B3 SLCO1C1 solute carrier organic anion transporter family, member 1C1 SLCO2A1 solute carrier organic anion transporter family, member 2A1 SLCO2B1 solute carrier organic anion transporter family, member 2B1 SLCO3A1 solute carrier organic anion transporter family, member 3A1 SLCO4A1 solute carrier organic anion transporter family, member 4A1 SLCO4C1 solute carrier organic anion transporter family, member 4C1 SLCO5A1 solute carrier organic anion transporter family, member 5A1 SLCO6A1 solute carrier organic anion transporter family, member 6A1 SOD1 superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) SOD2 superoxide dismutase 2, mitochondrial SOD3 superoxide dismutase 3, extracellular SOX4 SRY (sex determining region Y)-box 4 SP1 Sp1 transcription factor SPINK1 serine protease inhibitor, Kazal type 1 18 SPINK2 SPINK4 SPINK5 SPINLW1 SPINT1 SPINT2 SPINT3 SPP2 SPRY4 SPTAN1 SPTBN1 SQLE SREBF1 SREBF2 ST14 ST3GAL1 SULT1A1 SULT1A2 SULT1B1 SULT1C1 SULT1C2 SULT1E1 SULT2A1 SULT2B1 SULT4A1 TAGLN2; NESG1 TAP1 TAP2 TAT TBX15 TCEA2 TCF1 TDE2L TDO2 TF TGFA TGFB1 TGFBI TGM2 THRA serine protease inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) serine protease inhibitor, Kazal type 4 serine protease inhibitor, Kazal type 5 serine protease inhibitor-like, with Kunitz and WAP domains 1 (eppin) serine protease inhibitor, Kunitz type 1 serine protease inhibitor, Kunitz type, 2 serine protease inhibitor, Kunitz type, 3 secreted phosphoprotein 2, 24kDa trophoblast-derived noncoding RNA spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) spectrin, beta, non-erythrocytic 1 squalene epoxidase sterol regulatory element binding transcription factor 1 sterol regulatory element binding transcription factor 2 suppression of tumorigenicity 14 (colon carcinoma, matriptase, epithin) sialyltransferase 4A (beta-galactoside alpha-2,3-sialyltransferase); hypothetical protein LOC286167 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 sulfotransferase family, cytosolic, 1B, member 1 sulfotransferase family, cytosolic, 1C, member 1; hypothetical protein LOC151234 sulfotransferase family, cytosolic, 1C, member 2 sulfotransferase family 1E, estrogen-preferring, member 1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA) preferring, member 1 sulfotransferase family, cytosolic, 2B, member 1 sulfotransferase family 4A, member 1 transgelin 2; nasopharyngeal epithelium specific protein 1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) tyrosine aminotransferase T-box 15 transcription elongation factor A (SII), 2 transcription factor 1, hepatic; LF-B1, hepatic nuclear factor (HNF1), albumin proximal factor tumor differentially expressed 2-like tryptophan 2,3-dioxygenase transferrin transforming growth factor, alpha transforming growth factor, beta 1 (Camurati-Engelmann disease); hypothetical protein MGC4093 transforming growth factor, beta-induced, 68kDa transglutaminase 2 (C polypeptide, protein-glutamine-gammaglutamyltransferase) thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian) 19 THRSP thyroid hormone responsive (SPOT14 homolog, rat) TMEM100 hypothetical protein FLJ10970 TMEM106B hypothetical protein FLJ11273 TMEM7 transmembrane protein 7 TMPRSS2 transmembrane protease, serine 2 TMPRSS3 transmembrane protease, serine 3 TMPRSS4 transmembrane protease, serine 4 TMPRSS5 transmembrane protease, serine 5 (spinesin) TMPRSS6 transmembrane protease, serine 6 TMPRSS7 transmembrane serine protease 7 TMPRSS9 transmembrane serine protease 9 TNA tetranectin (plasminogen binding protein) TNF tumor necrosis factor (TNF superfamily, member 2) TNFRSF1A tumor necrosis factor receptor superfamily, member 1A TNFRSF1B tumor necrosis factor receptor superfamily, member 1B TNFRSF21 tumor necrosis factor receptor superfamily, member 21 TP53I3 tumor protein p53 inducible protein 3 TPMT thiopurine S-methyltransferase; thiopurine S-methyltransferase pseudogene TPSAB1; TPSB2 tryptase alpha/beta 1; tryptase beta 2 TPSD1 tryptase delta 1 TPSG1; TPSB2; TPSAB1 tryptase gamma 1; tryptase beta 2; tryptase alpha/beta 1 TUBA3; KALPHA-1 tubulin, alpha 3; tubulin, alpha, ubiquitous TUBA6 tubulin alpha 6 TUBB; TUBB2 tubulin, beta polypeptide; tubulin, beta polypeptide 2 UCP1 uncoupling protein 1 (mitochondrial, proton carrier) UCP2 uncoupling protein 2 (mitochondrial, proton carrier) UCP3 uncoupling protein 3 (mitochondrial, proton carrier) UGCG UDP-glucose ceramide glucosyltransferase UGT1A3; UGT1A6; UGT1A7; UGT1A1; UGT1A8; UGT1A9; UDP glycosyltransferase 1 family, polypeptide A3; UDP glycosyltransferase 1 UGT1A4; family, polypeptide A6; UDP glycosyltransferase 1 family, polypeptide A7; UDP UGT1A10; glycosyltransferase 1 family, polypeptide A1; UDP glycosyltransferase 1 family, UGT1A5 polypeptide A8; UDP g UGT2A1 UDP glycosyltransferase 2 family, polypeptide A1 UGT2B10 UDP glycosyltransferase 2 family, polypeptide B10 UGT2B11 UDP glycosyltransferase 2 family, polypeptide B11 UGT2B17 UDP glycosyltransferase 2 family, polypeptide B17 UGT2B28 UDP glycosyltransferase 2 family, polypeptide B28 UGT2B4; FLJ21934 UDP glycosyltransferase 2 family, polypeptide B4; hypothetical protein FLJ21934 20 UGT2B7 UGT8 UNQ9391 USP15 VDR VEGF VEGFB VEGFC VIL1 WBSCR14 WNT1 WNT10A WNT10B WNT11 WNT16 WNT2 WNT2B WNT3 WNT3A WNT4 WNT5A WNT5B WNT6 WNT7A WNT8A WNT8B WNT9A WNT9B XPNPEP2 ZBTB16 ZCCHC6 ZCWCC2 ZFP1 ZYX UDP glycosyltransferase 2 family, polypeptide B7 UDP glycosyltransferase 8 (UDP-galactose ceramide galactosyltransferase) tryptophan/serine protease ubiquitin specific protease 15 vitamin D (1,25- dihydroxyvitamin D3) receptor vascular endothelial growth factor vascular endothelial growth factor B vascular endothelial growth factor C villin 1 Williams Beuren syndrome chromosome region 14 wingless-type MMTV integration site family, member 1 wingless-type MMTV integration site family, member 10A wingless-type MMTV integration site family, member 10B wingless-type MMTV integration site family, member 11 wingless-type MMTV integration site family, member 16 wingless-type MMTV integration site family member 2 wingless-type MMTV integration site family, member 2B wingless-type MMTV integration site family, member 3 wingless-type MMTV integration site family, member 3A wingless-type MMTV integration site family, member 4 wingless-type MMTV integration site family, member 5A wingless-type MMTV integration site family, member 5B wingless-type MMTV integration site family, member 6 wingless-type MMTV integration site family, member 7A wingless-type MMTV integration site family, member 8A wingless-type MMTV integration site family, member 8B wingless-type MMTV integration site family, member 9A wingless-type MMTV integration site family, member 9B X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound zinc finger and BTB domain containing 16 zinc finger, CW type with coiled-coil domain 2 zinc finger protein 1 homolog (mouse) zyxin 21 Supplementary Figure 1. Genotype case-control test p-values of matched vs. unmatched analysis for the top 500 SNPs (selection based on p_min) in the candidate gene study. In the comparison of the matched and unmatched analyses, 464 of the top 500 ranked SNPs from both analyses were included in both lists, showing strong agreement between the matched and unmatched analysis. Supplementary Figure 1 shows the log p-value (minimum of the two genotype case-control tests including/excluding intermediates) of the matched and unmatched analyses for the top 500 SNPs, selected on the basis of the minimum p-value of all 6 single locus analyses. The majority of SNPs show good concordance between matched and unmatched analyses.