Download Genetic association to ALAT elevations during

1
Genome-wide pharmacogenetic investigation of a hepatic adverse event
without clinical signs of immunopathology suggests an underlying
immune pathogenesis
Supplementary note 1.
The highest-ranking SNP (rs2858869) in Phase 1 of EXGEN was not included in the set of
250,000 tag SNPs selected for the GWS. Hence, if DRB1 had not been included as a
candidate gene, the highest-ranking SNP in the HLA region from the tag SNP set would have
been rs707937 (p=1.95 x 10-4), which is 14kb from VARS2 and 841kb from rs2858869.
According to the strategy followed in this study, this SNP did not meet the threshold for
follow-up (p10-5) and hence was not selected for further study.
If, however, we had followed only a GWS strategy using these tag SNPs, this and
other SNPs in the MHC class II region would have been among the top-ranked 650
associations, and hence would likely have been carried forward for subsequent fine mapping.
The increased density of SNPs across the MHC region would then have uncovered the
primary association with the DRB1 and DQA1 genes.
Similarly, if the GWS and candidate gene study results had been combined and
analysed together, the rs2858869 SNP would still have been among the highest-ranked and
would have been carried forward for further fine mapping studies. It is likely, however, that
the FDR and other analyses may not have been as clear-cut, with the signal-to-noise ratio
being lower in the combined SNP set.
We conclude that the details of our analysis strategy were not vital in discovering the
primary association with the DRB1 and DQA1 genes, and that alternative strategies would
likely have resulted in the same discovery. We do recommend, however, that a dense map
of markers be used for initial screening (particularly in gene-dense areas like the HLA region)
and that fine mapping with an increased density of markers be carried out in the same
sample set, before selection of the highest-ranked markers for replication testing in an
independent sample set.
2
Supplementary table 1
Patient population and disposition for EXGEN
Cases
N=78
Controls
N=131
Intermediate
N=39
Total
N=248
73
1
36
5
16
24
5
3
0
7
142
9
55
8
34
130 a
130 (99%)
131
39
39 (100)
39
243
243 (98%)
248
70 (25 to 88)
77.2(54 to 110)
78 (60)
52 (40)
130 (100)
69 (57 to 87)
78.8(62 to 110)
24 (62)
15 (38)
39 (100)
70 (25 to 89)
76.6(50 to 110)
140 (58)
103 (42)
243 (100)
0.4 (0.2)
0.6 (0.4)
0.5 (0.3)
0.6 (0.2)
1.5 (0.6)
2.7 (3.7)
Study
SPORTIF III
45
SPORTIF IV
3
ESTEEM
16
THRIVE II
3
THRIVE III
11
Disposition
Total
74a
N (%) of subjects who completed
74 (95%)
Safety population
78
Demographic and baseline characteristicsb
Age (years)
Mean (range) 71 (25 to 89)
Weight (kg)
Mean (range) 74.2(50 to 107)
Sex (n (%) of
Male
38 (51)
subjects)
Female
36 (49)
Race (n (%) of
Caucasian
74 (100)
subjects)
Baseline (preMean (SD)
0.5 (0.3)
treatment) ALAT
(xULN)
Maximum ALAT
Mean (SD)
7.1 (4.1)
(xULN)
3
Supplementary table 2. Patient population used for the LTT study
Groups and numbers
Group 1
Ximelagatran exposed
individuals who
discontinued treatment
at ALAT>4xULN
Group 2
Ximelagatran exposed
individuals who
continued treatment at
ALAT>4xULN
N=13
N=8
Group 3
Ximelagatran exposed
individuals with
ALAT<1xULN and not
exceeding 2x baseline
value
N=21
Group 4
Test subjects not
exposed to
ximelagatran
N=10
Subjects (cases and matched controls) were preselected from previous long-term treatment studies
with ximelagatran: ESTEEM, SPORTIF III, THRIVE III and THRIVE Treatment. The subjects were
selected from clinical databases by AstraZeneca. The study was carried out in centres in Sweden.
Subjects who had not previously taken part in EXGEN (10 cases from groups 1 & 2 and 16 controls
from group 3) were used for replication testing.
4
Supplementary Table 3. 690 candidate genes selected on the basis of (i) the mechanism
of ximelagatran, (ii) reported association with elevated liver enzymes and (iii) additional
preclinical studies. SNPs were selected for each gene (defined by NCBI build 35), and
10kb flanking sequence. A sliding window approach was used to pick SNPs at a spacing
of approximately 6 SNPs every 10kb (a total of 26,613 SNPs).
Official
Symbol
A1BG
AASS
AATF
ABCA1
ABCA10
ABCA12
ABCA13
ABCA2
ABCA3
ABCA4
ABCA5
ABCA6
ABCA7
ABCA8
ABCA9
ABCB1
ABCB10
ABCB11
ABCB4
ABCB5
ABCB6
ABCB7
ABCB8
ABCB9
ABCC1
ABCC10
ABCC11
ABCC12
ABCC13
ABCC2
ABCC3
ABCC4
ABCC5
ABCC6
ABCC8
ABCC9
ABCD1
Gene Name
alpha-1-B glycoprotein; zinc finger protein 497
aminoadipate-semialdehyde synthase
apoptosis antagonizing transcription factor
ATP-binding cassette, sub-family A (ABC1), member 1
ATP-binding cassette, sub-family A (ABC1), member 10
ATP-binding cassette, sub-family A (ABC1), member 12
ATP binding cassette gene, sub-family A (ABC1), member 13
ATP-binding cassette, sub-family A (ABC1), member 2
ATP-binding cassette, sub-family A (ABC1), member 3
ATP-binding cassette, sub-family A (ABC1), member 4
ATP-binding cassette, sub-family A (ABC1), member 5
ATP-binding cassette, sub-family A (ABC1), member 6
ATP-binding cassette, sub-family A (ABC1), member 7
ATP-binding cassette, sub-family A (ABC1), member 8
ATP-binding cassette, sub-family A (ABC1), member 9
ATP-binding cassette, sub-family B (MDR/TAP), member 1
ATP-binding cassette, sub-family B (MDR/TAP), member 10
ATP-binding cassette, sub-family B (MDR/TAP), member 11
ATP-binding cassette, sub-family B (MDR/TAP), member 4
ATP-binding cassette, sub-family B (MDR/TAP), member 5
ATP-binding cassette, sub-family B (MDR/TAP), member 6
ATP-binding cassette, sub-family B (MDR/TAP), member 7
ATP-binding cassette, sub-family B (MDR/TAP), member 8; amiloride-sensitive
cation channel 3
ATP-binding cassette, sub-family B (MDR/TAP), member 9
ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ATP-binding cassette, sub-family C (CFTR/MRP), member 10
ATP-binding cassette, sub-family C (CFTR/MRP), member 11
ATP-binding cassette, sub-family C (CFTR/MRP), member 12
ATP-binding cassette, sub-family C (CFTR/MRP), member 13
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
ATP-binding cassette, sub-family D (ALD), member 1
5
ABCD2
ABCD3
ABCD4
ABCE1
ABCF1
ABCF2
ABCF3
ABCG1
ABCG2
ABCG4
ABCG5
ABCG8
ACAA2
ACACA
ACAT1
ACAT2
ACATE2
ACDC
ACE
ACF
ACHE
ACLY
ACOX1
ACOX2
ACOX3
ACSL1
ADIPOR1
ADIPOR2
ADRA1A
AF1Q
AGT
AKR1B10
ALDH1A1
ALDH1A2
ALDH1A3
ALDH1B1
ALDH2
ALDH3A1
ALDH3A2
ALDH3B1
ALDH3B2
ALDH4A1
ALDH5A1
ALDH6A1
ATP-binding cassette, sub-family D (ALD), member 2
ATP-binding cassette, sub-family D (ALD), member 3
ATP-binding cassette, sub-family D (ALD), member 4
ATP-binding cassette, sub-family E (OABP), member 1
ATP-binding cassette, sub-family F (GCN20), member 1
ATP-binding cassette, sub-family F (GCN20), member 2
ATP-binding cassette, sub-family F (GCN20), member 3
ATP-binding cassette, sub-family G (WHITE), member 1
ATP-binding cassette, sub-family G (WHITE), member 2
ATP-binding cassette, sub-family G (WHITE), member 4
ATP-binding cassette, sub-family G (WHITE), member 5 (sterolin 1)
ATP-binding cassette, sub-family G (WHITE), member 8 (sterolin 2)
acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A
thiolase)
acetyl-Coenzyme A carboxylase alpha
acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase)
acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase)
likely ortholog of mouse acyl-Coenzyme A thioesterase 2, mitochondrial
adipocyte, C1Q and collagen domain containing
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
apobec-1 complementation factor
acetylcholinesterase (YT blood group)
ATP citrate lyase
acyl-Coenzyme A oxidase 1, palmitoyl
acyl-Coenzyme A oxidase 2, branched chain
acyl-Coenzyme A oxidase 3, pristanoyl
acyl-CoA synthetase long-chain family member 1
adiponectin receptor 1
adiponectin receptor 2
adrenergic, alpha-1A-, receptor
ALL1-fused gene from chromosome 1q
angiotensinogen (serine (or cysteine) proteinase inhibitor, clade A (alpha-1
antiproteinase, antitrypsin), member 8)
aldo-keto reductase family 1, member B10 (aldose reductase)
aldehyde dehydrogenase 1 family, member A1
aldehyde dehydrogenase 1 family, member A2
aldehyde dehydrogenase 1 family, member A3
aldehyde dehydrogenase 1 family, member B1
aldehyde dehydrogenase 2 family (mitochondrial)
aldehyde dehydrogenase 3 family, memberA1
aldehyde dehydrogenase 3 family, member A2
aldehyde dehydrogenase 3 family, member B1
aldehyde dehydrogenase 3 family, member B2
aldehyde dehydrogenase 4 family, member A1
aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde
dehydrogenase)
aldehyde dehydrogenase 6 family, member A1
6
ALDH7A1
ALDH8A1
ALDH9A1
ANGPTL4
ANKRD28
APBA1
APOA1
APOA2
APOB
APOBEC1
APOC2;
APOC4
APOC3
APOE
AREG
ARMET
ARNT
ARNT2
ASB13
ASL
aldehyde dehydrogenase 7 family, member A1
aldehyde dehydrogenase 8 family, member A1
aldehyde dehydrogenase 9 family, member A1
angiopoietin-like 4
ankyrin repeat domain 28
amyloid beta (A4) precursor protein-binding, family A, member 1 (X11)
apolipoprotein A-I
apolipoprotein A-II
apolipoprotein B (including Ag(x) antigen)
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
apolipoprotein C-II; apolipoprotein C-IV
apolipoprotein C-III
apolipoprotein E
amphiregulin (schwannoma-derived growth factor)
arginine-rich, mutated in early stage tumors
aryl hydrocarbon receptor nuclear translocator
aryl-hydrocarbon receptor nuclear translocator 2
ankyrin repeat and SOCS box-containing 13
argininosuccinate lyase
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine
BBOX1
hydroxylase) 1
BCHE
butyrylcholinesterase
branched chain keto acid dehydrogenase E1, beta polypeptide (maple syrup
BCKDHB urine disease)
BHLHB2
basic helix-loop-helix domain containing, class B, 2
BHMT
betaine-homocysteine methyltransferase
BLNK
B-cell linker
BMP2
bone morphogenetic protein 2
BTC
betacellulin
BTEB1
basic transcription element binding protein 1
CAMK2G; calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma; NNDST2
deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
CARM1
coactivator-associated arginine methyltransferase 1
CAT
catalase
CCL2
chemokine (C-C motif) ligand 2
CCNG1
cyclin G1
CD109
CD109 antigen (Gov platelet alloantigens)
CD44
CD44 antigen (homing function and Indian blood group system)
CDO1
cysteine dioxygenase, type I
CDT6
angiopoietin-like factor
CEP57
translokin
Cep70
p10-binding protein
cystic fibrosis transmembrane conductance regulator, ATP-binding cassette
CFTR
(sub-family C, member 7)
CHN2
chimerin (chimaerin) 2
CLYBL
citrate lyase beta like
7
CML2
COBLL1
COMT
COQ3
COQ4
COQ6
COQ7
CORIN
CPT2
CREB3L2
CRYAA
CSF1
CUTL2
CYB5
CYB5R2
CYP1A1
CYP1A2
CYP1B1
CYP2A6
CYP2B6
CYP2C19;
CYP2C18
CYP2C8
CYP2C9
CYP2D6
CYP2E1
CYP39A1
CYP3A4
CYP3A5;
CYP3A5P2
CYP4A11;
CYP4A22
CYP51A1
CYP7A1
CYR61
DDT
DECR1
DEPDC7
DHCR7
DIA1
DIO1
DNMT1
DNMT2
DNMT3A
DNMT3B
DOC1
putative N-acetyltransferase Camello 2
COBL-like 1
catechol-O-methyltransferase
coenzyme Q3 homolog, methyltransferase (yeast)
coenzyme Q4 homolog (yeast)
coenzyme Q6 homolog (yeast)
coenzyme Q7 homolog, ubiquinone (yeast)
corin, serine protease
carnitine palmitoyltransferase II
cAMP responsive element binding protein 3-like 2
crystallin, alpha A
colony stimulating factor 1 (macrophage)
cut-like 2 (Drosophila)
cytochrome b-5
cytochrome b5 reductase b5R.2
cytochrome P450, family 1, subfamily A, polypeptide 1
cytochrome P450, family 1, subfamily A, polypeptide 2
cytochrome P450, family 1, subfamily B, polypeptide 1
cytochrome P450, family 2, subfamily A, polypeptide 6; egl nine homolog 2 (C.
elegans)
cytochrome P450, family 2, subfamily B, polypeptide 6
cytochrome P450, family 2, subfamily C, polypeptide 19; cytochrome P450,
family 2, subfamily C, polypeptide 18
cytochrome P450, family 2, subfamily C, polypeptide 8
cytochrome P450, family 2, subfamily C, polypeptide 9
cytochrome P450, family 2, subfamily D, polypeptide 6
cytochrome P450, family 2, subfamily E, polypeptide 1
cytochrome P450, family 39, subfamily A, polypeptide 1
cytochrome P450, family 3, subfamily A, polypeptide 4
cytochrome P450, family 3, subfamily A, polypeptide 5; cytochrome P450, family
3, subfamily A, polypeptide 5 pseudogene 2
cytochrome P450, family 4, subfamily A, polypeptide 11; cytochrome P450,
family 4, subfamily A, polypeptide 22
cytochrome P450, family 51, subfamily A, polypeptide 1
cytochrome P450, family 7, subfamily A, polypeptide 1
cysteine-rich, angiogenic inducer, 61
D-dopachrome tautomerase
2,4-dienoyl CoA reductase 1, mitochondrial
novel 58.3 KDA protein
7-dehydrocholesterol reductase
diaphorase (NADH) (cytochrome b-5 reductase)
deiodinase, iodothyronine, type I
DNA (cytosine-5-)-methyltransferase 1
DNA (cytosine-5-)-methyltransferase 2
DNA (cytosine-5-)-methyltransferase 3 alpha
DNA (cytosine-5-)-methyltransferase 3 beta
downregulated in ovarian cancer 1
8
DOC-1R
DPP4
DPYD
DSIPI
DTR
ECHS1
EEF1A2
EGF
EGFR
EI24
ELA2
ELOVL6
ELOVL6
EMP2
EPHX1
tumor suppressor deleted in oral cancer-related 1
dipeptidylpeptidase 4 (CD26, adenosine deaminase complexing protein 2)
dihydropyrimidine dehydrogenase
delta sleep inducing peptide, immunoreactor
diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth
factor)
enoyl Coenzyme A hydratase, short chain, 1, mitochondrial
eukaryotic translation elongation factor 1 alpha 2
epidermal growth factor (beta-urogastrone)
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b)
oncogene homolog, avian)
etoposide induced 2.4 mRNA
elastase 2, neutrophil
ELOVL family member 6, elongation of long chain fatty acids (FEN1/Elo2,
SUR4/Elo3-like, yeast)
epithelial membrane protein 2
epoxide hydrolase 1, microsomal (xenobiotic)
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma
ERBB2
derived oncogene homolog (avian); chromosome 17 open reading frame 37
protein disulfide isomerase related protein (calcium-binding protein, intestinalERP70
related)
ETFDH
electron-transferring-flavoprotein dehydrogenase
F10
coagulation factor X
F11
coagulation factor XI (plasma thromboplastin antecedent)
F2
coagulation factor II (thrombin)
F2R
coagulation factor II (thrombin) receptor
F5
coagulation factor V (proaccelerin, labile factor)
F7
coagulation factor VII (serum prothrombin conversion accelerator)
F8
coagulation factor VIII, procoagulant component (hemophilia A)
coagulation factor IX (plasma thromboplastic component, Christmas disease,
F9
hemophilia B)
fatty acid binding protein 5 (psoriasis-associated); fatty acid binding protein 5-like
3; similar to Fatty acid-binding protein, epidermal (E-FABP) (Psoriasis-associated
FABP5
fatty acid-binding protein homolog) (PA-FABP)
FADS1
fatty acid desaturase 1
FADS2
fatty acid desaturase 2
FADS3
fatty acid desaturase 3
FAM13A1 family with sequence similarity 13, member A1
FAM34A
family with sequence similarity 34, member A
FAM46C family with sequence similarity 46, member C
FASN
fatty acid synthase
FDFT1
farnesyl-diphosphate farnesyltransferase 1
farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase,
FDPS
dimethylallyltranstransferase, geranyltranstransferase)
FGF13
fibroblast growth factor 13
FGF2
fibroblast growth factor 2 (basic)
FGF21
fibroblast growth factor 21
9
FGF23
fibroblast growth factor 23
fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte
growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer
FGFR2
syndrome, Jackson-Weiss syndrome)
FKBP5
FK506 binding protein 5; hypothetical protein LOC285847
FLJ14981 hypothetical protein FLJ14981
FLJ20701 hypothetical protein FLJ20701
FLRT3
fibronectin leucine rich transmembrane protein 3
FOXO3A forkhead box O3A
FRZB
frizzled-related protein
FTHFD
formyltetrahydrofolate dehydrogenase
FXN
frataxin
G6PD
glucose-6-phosphate dehydrogenase
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1; ubiquitin D
GAMT
guanidinoacetate N-methyltransferase
GARS
glycyl-tRNA synthetase
GAS2
growth arrest-specific 2
GFPT1
glutamine-fructose-6-phosphate transaminase 1
GGPS1
geranylgeranyl diphosphate synthase 1
GHR
growth hormone receptor
GLCE
glucuronyl C5-epimerase
GLUL
glutamate-ammonia ligase (glutamine synthase)
GLYAT
glycine-N-acyltransferase
GNMT
glycine N-methyltransferase
GNS
glucosamine (N-acetyl)-6-sulfatase (Sanfilippo disease IIID)
GOT1
glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)
GPAM
glycerol-3-phosphate acyltransferase, mitochondrial
GPHN
gephyrin
G protein-coupled receptor 125; similar to single stranded DNA binding protein 4;
GPR125
dispatched homolog 2 (Drosophila)
GPR177
putative NFkB activating protein 373
GPRC5B G protein-coupled receptor, family C, group 5, member B
GPT
glutamic-pyruvate transaminase (alanine aminotransferase)
GPT2
glutamic pyruvate transaminase (alanine aminotransferase) 2
GPX1
glutathione peroxidase 1
GPX2
glutathione peroxidase 2 (gastrointestinal)
GPX3
glutathione peroxidase 3 (plasma)
GPX4
glutathione peroxidase 4 (phospholipid hydroperoxidase)
GPX5
glutathione peroxidase 5 (epididymal androgen-related protein)
GPX6
glutathione peroxidase 6 (olfactory)
GPX7
glutathione peroxidase 7
GPXP2
GSN
gelsolin (amyloidosis, Finnish type)
GSR
glutathione reductase
GSS
glutathione synthetase
GSTA2
glutathione S-transferase A2
GSTA3
glutathione S-transferase A3
10
GSTA4
GSTA5
GSTK1
GSTM1
GSTM3
GSTM5
GSTO1
GSTO2
GSTP1
GSTT1
GSTT2
GSTZ1
GYS1
GYS2
GZMK
glutathione S-transferase A4
glutathione S-transferase A5
glutathione S-transferase kappa 1
glutathione S-transferase M2 (muscle); glutathione S-transferase M4; glutathione
S-transferase M1
glutathione S-transferase M3 (brain)
glutathione S-transferase M5
glutathione S-transferase omega 1
glutathione S-transferase omega 2
glutathione S-transferase pi
glutathione S-transferase theta 1
glutathione S-transferase theta 2
glutathione transferase zeta 1 (maleylacetoacetate isomerase)
glycogen synthase 1 (muscle)
glycogen synthase 2 (liver)
granzyme K (serine protease, granzyme 3; tryptase II)
hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A
thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit
hepatocellular carcinoma-associated antigen 112
chromosome 14 open reading frame 68
hemochromatosis
hepatocyte growth factor (hepapoietin A; scatter factor)
hypothetical protein FLJ22761
major histocompatibility complex, class I, A
major histocompatibility complex, class I, B; major histocompatibility complex,
class I, C
HADHA
HCA112
HDMCP
HFE
HGF
HKDC1
HLA-A
HLA-B;
HLA-C
HLA-DRB1;
HLA-DRB3;
HLA-DRB5;
HLA-DRB2;
HLA-DQB1; major histocompatibility complex, class II, DR beta 1; major histocompatibility
HLA-DQB2; complex, class II, DR beta 3; major histocompatibility complex, class II, DR beta
HLA-DRB4; 5; major histocompatibility complex, class II, DR beta 2; major histocompatibility
HLA-DRB6 complex, c
HLA-DRB5 major histocompatibility complex, class II, DR beta 5
HLF
hepatic leukemia factor
HMBS
hydroxymethylbilane synthase
3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
HMGCL
(hydroxymethylglutaricaciduria)
HMGCR
3-hydroxy-3-methylglutaryl-Coenzyme A reductase
HMGCS1 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)
HMGCS2 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial)
HNF4A
hepatocyte nuclear factor 4, alpha; hypothetical protein FLJ39654
HPN
hepsin (transmembrane protease, serine 1)
HRIHFB21
22
Tara-like protein
HS2ST1
heparan sulfate 2-O-sulfotransferase 1; hypothetical protein LOC339524
HS3ST1
heparan sulfate (glucosamine) 3-O-sulfotransferase 1
11
HS3ST2
HS3ST3B1
HS3ST4
HS3ST5
HS6ST1
HS6ST2
HS6ST3
HSPA5
HSPC280
HTRA3
HYAL1
HYOU1
ICMT
ID1
IDH2
IDI1
IER3
IFNG
IGF1
IGF1R
IGF2
IGF2R
IGFBP3
IGFBP4
IL17RB
IL1A
IL1B
IL6
INMT
INSR
IRS1
IRS2
IRS4
JUB
KAZALD1
KCTD14
KDELR2
KDELR3
KIS
KLB
KLK1
KLK10
KLK11
KLK12
KLK13
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
heparan sulfate (glucosamine) 3-O-sulfotransferase 4
heparan sulfate (glucosamine) 3-O-sulfotransferase 5
heparan sulfate 6-O-sulfotransferase 1
heparan sulfate 6-O-sulfotransferase 2
heparan sulfate 6-O-sulfotransferase 3
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
chromosome 6 open reading frame 115
serine protease HTRA3
hyaluronoglucosaminidase 3; hyaluronoglucosaminidase 1; N-acetyltransferase 6
hypoxia up-regulated 1
isoprenylcysteine carboxyl methyltransferase
inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
isocitrate dehydrogenase 2 (NADP+), mitochondrial
isopentenyl-diphosphate delta isomerase
immediate early response 3
interferon, gamma
insulin-like growth factor 1 (somatomedin C)
insulin-like growth factor 1 receptor
insulin-like growth factor 2 (somatomedin A)
insulin-like growth factor 2 receptor
insulin-like growth factor binding protein 3
insulin-like growth factor binding protein 4
interleukin 17 receptor B
interleukin 1, alpha
interleukin 1, beta
interleukin 6 (interferon, beta 2)
indolethylamine N-methyltransferase
insulin receptor
insulin receptor substrate 1
insulin receptor substrate 2
insulin receptor substrate 4
jub, ajuba homolog (Xenopus laevis)
Kazal-type serine protease inhibitor domain 1
potassium channel tetramerisation domain containing 14
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2;
KCCR13L
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
kinase interacting with leukemia-associated gene (stathmin)
klotho beta like
kallikrein 1, renal/pancreas/salivary
kallikrein 10
kallikrein 11
kallikrein 12
kallikrein 13
12
KLK14
KLK15
KLK2
KLK3
KLK4
KLK5
KLK6
KLK7;
KLK8
KLK9
KLKB1
KRT8
LDLR
LECT2
LGALS1
LGALS4
LIPC
LIPG
LOC12387
6
LOC14970
3
LOXL4
LPL
LRRC8
LSS
MAC30
MAFB
MAGI1
MAN1C1
MANEA
MAP2
MARCKS
kallikrein 14
kallikrein 15
kallikrein 2, prostatic
kallikrein 3, (prostate specific antigen)
kallikrein 4 (prostase, enamel matrix, prostate)
kallikrein 5
kallikrein 6 (neurosin, zyme)
kallikrein 7 (chymotryptic, stratum corneum); kallikrein 8 (neuropsin/ovasin)
kallikrein 9
kallikrein B, plasma (Fletcher factor) 1
keratin 8
low density lipoprotein receptor (familial hypercholesterolemia)
leukocyte cell-derived chemotaxin 2
lectin, galactoside-binding, soluble, 1 (galectin 1)
lectin, galactoside-binding, soluble, 4 (galectin 4)
lipase, hepatic
lipase, endothelial
hypothetical protein LOC123876
hypothetical protein LOC149703
lysyl oxidase-like 4
lipoprotein lipase
leucine rich repeat containing 8
lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
hypothetical protein MAC30
v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)
membrane associated guanylate kinase interacting protein-like 1
mannosidase, alpha, class 1C, member 1
mannosidase, endo-alpha
microtubule-associated protein 2
myristoylated alanine-rich protein kinase C substrate
mannan-binding lectin serine protease 1 (C4/C2 activating component of RaMASP1
reactive factor); mannan-binding lectin serine protease 1 pseudogene 1
MASP2
mannan-binding lectin serine protease 2
MBTPS1 membrane-bound transcription factor protease, site 1
membrane-bound transcription factor protease, site 2; hypothetical protein
MBTPS2 LOC203411; YY2 transcription factor
ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
ME2
malic enzyme 2, NAD(+)-dependent, mitochondrial
ME3
malic enzyme 3, NADP(+)-dependent, mitochondrial
MEIS1
Meis1, myeloid ecotropic viral integration site 1 homolog (mouse)
MFRP
membrane frizzled-related protein
MGC4083 tubulin beta MGC4083
MGC4677 hypothetical protein MGC4677
MGST1
microsomal glutathione S-transferase 1
13
MGST2
MGST3
MIG-6
MME
MMP12
MSP
MT1X
MTP
MTR
MUSTN1
MVD
MVK
MYH9
MYO5B
NAT1
NAT2
NAT5
NAT8
NCB5OR
NCOA2
NDST1
NDST3
NDST4
NK4
NNMT
NOS1
NQO1
NQO2
NR1H2
NR1H3
NR1I2
NR1I3
NR2F2
NR3C1
NUCB2
OAF
OAT
OSTalpha
P11
PANK1
PAPSS2
PBX1
PCDH20
microsomal glutathione S-transferase 2
microsomal glutathione S-transferase 3
mitogen-inducible gene 6
membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase,
CALLA, CD10)
matrix metalloproteinase 12 (macrophage elastase)
mosaic serine protease
metallothionein 1X
microsomal triglyceride transfer protein (large polypeptide, 88kDa)
5-methyltetrahydrofolate-homocysteine methyltransferase; hypothetical protein
LOC149448
musculoskeletal, embryonic nuclear protein 1; Similar to RIKEN cDNA
1810038N08 gene; inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive
glycoprotein)
mevalonate (diphospho) decarboxylase
mevalonate kinase (mevalonic aciduria)
myosin, heavy polypeptide 9, non-muscle
myosin VB
N-acetyltransferase 1 (arylamine N-acetyltransferase)
N-acetyltransferase 2 (arylamine N-acetyltransferase)
N-acetyltransferase 5 (ARD1 homolog, S. cerevisiae)
N-acetyltransferase 8 (camello like)
NADPH cytochrome B5 oxidoreductase
nuclear receptor coactivator 2
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4
natural killer cell transcript 4
nicotinamide N-methyltransferase
NAD(P)H dehydrogenase, quinone 1
NAD(P)H dehydrogenase, quinone 2
nuclear receptor subfamily 1, group H, member 2
nuclear receptor subfamily 1, group H, member 3
nuclear receptor subfamily 1, group I, member 2
nuclear receptor subfamily 1, group I, member 3
nuclear receptor subfamily 2, group F, member 2
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
nucleobindin 2
NS5ATP13TP2 protein
ornithine aminotransferase (gyrate atrophy)
organic solute transporter alpha
26 serine protease
pantothenate kinase 1
3'-phosphoadenosine 5'-phosphosulfate synthase 2
pre-B-cell leukemia transcription factor 1
protocadherin 20
14
PCDH9
PCK1
PCMT1
PDE4DIP
PDK4
PEG10
PF4
PGD;
KIF1B
PIK3R1
PKLR
PKM2
PLA2G12A
PLA2G2A
PLAT
PLAU
PLAUR
PLEK2
PLG
PMM2
PMVK
PNLIP
PNMT
PON1
POR
PPARA
PPARD
PPARG
PPIB
PPP1R3C
PR1
PRG2
PRKAA1
PRKAA2
PRKAB1
PRKAB2
PRKAG1
PRKAG2
PRKAG3
PRLR
PRMT7
PRO1855
PROC
PROCR
PRSS1
PRSS11
protocadherin 9
phosphoenolpyruvate carboxykinase 1 (soluble)
protein-L-isoaspartate (D-aspartate) O-methyltransferase
phosphodiesterase 4D interacting protein (myomegalin)
pyruvate dehydrogenase kinase, isoenzyme 4
paternally expressed 10
platelet factor 4 (chemokine (C-X-C motif) ligand 4)
phosphogluconate dehydrogenase; kinesin family member 1B
phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha)
pyruvate kinase, liver and RBC
pyruvate kinase, muscle
phospholipase A2, group XIIA
phospholipase A2, group IIA (platelets, synovial fluid)
plasminogen activator, tissue
plasminogen activator, urokinase
plasminogen activator, urokinase receptor
pleckstrin 2
plasminogen
phosphomannomutase 2
phosphomevalonate kinase
pancreatic lipase
phenylethanolamine N-methyltransferase
paraoxonase 1
P450 (cytochrome) oxidoreductase
peroxisome proliferative activated receptor, alpha
peroxisome proliferative activated receptor, delta
peroxisome proliferative activated receptor, gamma
peptidylprolyl isomerase B (cyclophilin B)
protein phosphatase 1, regulatory (inhibitor) subunit 3C
voltage-dependent calcium channel gamma subunit-like protein
proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule
major basic protein); solute carrier family 43, member 3
protein kinase, AMP-activated, alpha 1 catalytic subunit
protein kinase, AMP-activated, alpha 2 catalytic subunit
protein kinase, AMP-activated, beta 1 non-catalytic subunit
protein kinase, AMP-activated, beta 2 non-catalytic subunit
protein kinase, AMP-activated, gamma 1 non-catalytic subunit
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
protein kinase, AMP-activated, gamma 3 non-catalytic subunit
prolactin receptor
protein arginine N-methyltransferase 7
hypothetical protein PRO1855
protein C (inactivator of coagulation factors Va and VIIIa)
protein C receptor, endothelial (EPCR)
protease, serine, 1 (trypsin 1)
protease, serine, 11 (IGF binding)
15
PRSS12
PRSS15
PRSS2
PRSS22
PRSS23
PRSS25
PRSS3
PRSS33
PRSS35
PRSS7
PSTPIP2
PTEN
PTP4A1
PVRL2
PXMP2
RARA
RARB
RARG
RBP1
RBP2
RBP3
RBP4
RBP5
RBP7
RDH5
REPS1
RETN
RHOF
RORA
RORA
RPESP
RWDD3
RXRA
RXRB
RXRG
SARA2
SC5DL
SCAP
SCARB1
SCD
SCD4
SCDR10
SCDR9
SCGN
SDC2
protease, serine, 12 (neurotrypsin, motopsin)
protease, serine, 15
protease, serine, 2 (trypsin 2)
protease, serine, 22
protease, serine, 23
protease, serine, 25
protease, serine, 3 (mesotrypsin)
protease, serine, 33
protease, serine, 35
protease, serine, 7 (enterokinase)
proline-serine-threonine phosphatase interacting protein 2
phosphatase and tensin homolog (mutated in multiple advanced cancers 1)
protein tyrosine phosphatase type IVA, member 1
poliovirus receptor-related 2 (herpesvirus entry mediator B)
peroxisomal membrane protein 2, 22kDa
retinoic acid receptor, alpha
retinoic acid receptor, beta
retinoic acid receptor, gamma
retinol binding protein 1, cellular
retinol binding protein 2, cellular
retinol binding protein 3, interstitial
retinol binding protein 4, plasma
retinol binding protein 5, cellular; complement component 1, r subcomponent;
complement component 1, r subcomponent-like
retinol binding protein 7, cellular
retinol dehydrogenase 5 (11-cis and 9-cis); biogenesis of lysosome-related
organelles complex-1, subunit 1
RALBP1 associated Eps domain containing 1
resistin
ras homolog gene family, member F (in filopodia)
RAR-related orphan receptor A
RPE-spondin; hypothetical protein LOC286191
hypothetical protein FLJ31842
retinoid X receptor, alpha
retinoid X receptor, beta
retinoid X receptor, gamma
SAR1a gene homolog 2 (S. cerevisiae)
sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, fungal)-like
SREBP CLEAVAGE-ACTIVATING PROTEIN
scavenger receptor class B, member 1
stearoyl-CoA desaturase (delta-9-desaturase)
stearoyl-CoA desaturase 4
short-chain dehydrogenase/reductase 10
short-chain dehydrogenase/reductase 9
secretagogin, EF-hand calcium binding protein
syndecan 2 (heparan sulfate proteoglycan 1, cell surface-associated, fibroglycan)
16
SDCBP2
SEC61A1
SERPINA1
SERPINA1
0
SERPINA1
1
SERPINA1
2
SERPINA1
3
SERPINA2
SERPINA3
SERPINA4
SERPINA5
SERPINA6
SERPINA7
SERPINA9
SERPINB1
SERPINB1
0
SERPINB1
1
SERPINB1
2
SERPINB1
3
SERPINB2
SERPINB3
SERPINB4
SERPINB5
SERPINB6
SERPINB7
SERPINB8
SERPINB9
SERPINC1
SERPIND1
syndecan binding protein (syntenin) 2
Sec61 alpha 1 subunit (S. cerevisiae)
serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase,
antitrypsin), member 1
serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase,
antitrypsin), member 10
serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase,
antitrypsin), member 11
serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase,
antitrypsin), member 12
serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase,
antitrypsin), member 13
serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase,
antitrypsin), member 2
serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase,
antitrypsin), member 3
serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase,
antitrypsin), member 4
serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase,
antitrypsin), member 5
serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase,
antitrypsin), member 6
serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase,
antitrypsin), member 7
serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase,
antitrypsin), member 9
serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 1
serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 10
serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 11
serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 12
serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 13; UV-B
repressed sequence, HUR 7
serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 2
serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 3
serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 4
serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5
serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 6
serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 7
serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 8
serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 9
serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1
serine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member 1
serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator
SERPINE1 inhibitor type 1), member 1
serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator
SERPINE2 inhibitor type 1), member 2
serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment
SERPINF1 epithelium derived factor), member 1
17
serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment
SERPINF2 epithelium derived factor), member 2
serine (or cysteine) proteinase inhibitor, clade G (C1 inhibitor), member 1,
SERPING1 (angioedema, hereditary)
serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member
SERPINH1 1, (collagen binding protein 1)
SERPINI1 serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 1
SERPINI2 serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 2
SFN
stratifin
SFRP1
secreted frizzled-related protein 1
SFRP2
secreted frizzled-related protein 2
SFRP4
secreted frizzled-related protein 4
SFRP5
secreted frizzled-related protein 5
SHB
SHB (Src homology 2 domain containing) adaptor protein B
SIAT10
sialyltransferase 10 (alpha-2,3-sialyltransferase VI)
SIPA1L2 signal-induced proliferation-associated 1 like 2
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter family), member 1
SLC10A2 solute carrier family 10 (sodium/bile acid cotransporter family), member 2
SLC22A7 solute carrier family 22 (organic anion transporter), member 7
SLC22A8 solute carrier family 22 (organic anion transporter), member 8
SLC22A9 solute carrier family 22 (organic anion/cation transporter), member 9
SLC27A1 solute carrier family 27 (fatty acid transporter), member 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SLC29A1 solute carrier family 29 (nucleoside transporters), member 1
SLC2A1
solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC2A2
solute carrier family 2 (facilitated glucose transporter), member 2
SLC35C1 solute carrier family 35, member C1
SLC38A4 solute carrier family 38, member 4
SLCO1A2 solute carrier organic anion transporter family, member 1A2
SLCO1B1 solute carrier organic anion transporter family, member 1B1
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SLCO1C1 solute carrier organic anion transporter family, member 1C1
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SLCO2B1 solute carrier organic anion transporter family, member 2B1
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SLCO4C1 solute carrier organic anion transporter family, member 4C1
SLCO5A1 solute carrier organic anion transporter family, member 5A1
SLCO6A1 solute carrier organic anion transporter family, member 6A1
SOD1
superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult))
SOD2
superoxide dismutase 2, mitochondrial
SOD3
superoxide dismutase 3, extracellular
SOX4
SRY (sex determining region Y)-box 4
SP1
Sp1 transcription factor
SPINK1
serine protease inhibitor, Kazal type 1
18
SPINK2
SPINK4
SPINK5
SPINLW1
SPINT1
SPINT2
SPINT3
SPP2
SPRY4
SPTAN1
SPTBN1
SQLE
SREBF1
SREBF2
ST14
ST3GAL1
SULT1A1
SULT1A2
SULT1B1
SULT1C1
SULT1C2
SULT1E1
SULT2A1
SULT2B1
SULT4A1
TAGLN2;
NESG1
TAP1
TAP2
TAT
TBX15
TCEA2
TCF1
TDE2L
TDO2
TF
TGFA
TGFB1
TGFBI
TGM2
THRA
serine protease inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
serine protease inhibitor, Kazal type 4
serine protease inhibitor, Kazal type 5
serine protease inhibitor-like, with Kunitz and WAP domains 1 (eppin)
serine protease inhibitor, Kunitz type 1
serine protease inhibitor, Kunitz type, 2
serine protease inhibitor, Kunitz type, 3
secreted phosphoprotein 2, 24kDa
trophoblast-derived noncoding RNA
spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
spectrin, beta, non-erythrocytic 1
squalene epoxidase
sterol regulatory element binding transcription factor 1
sterol regulatory element binding transcription factor 2
suppression of tumorigenicity 14 (colon carcinoma, matriptase, epithin)
sialyltransferase 4A (beta-galactoside alpha-2,3-sialyltransferase); hypothetical
protein LOC286167
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
sulfotransferase family, cytosolic, 1B, member 1
sulfotransferase family, cytosolic, 1C, member 1; hypothetical protein
LOC151234
sulfotransferase family, cytosolic, 1C, member 2
sulfotransferase family 1E, estrogen-preferring, member 1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA) preferring, member 1
sulfotransferase family, cytosolic, 2B, member 1
sulfotransferase family 4A, member 1
transgelin 2; nasopharyngeal epithelium specific protein 1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
tyrosine aminotransferase
T-box 15
transcription elongation factor A (SII), 2
transcription factor 1, hepatic; LF-B1, hepatic nuclear factor (HNF1), albumin
proximal factor
tumor differentially expressed 2-like
tryptophan 2,3-dioxygenase
transferrin
transforming growth factor, alpha
transforming growth factor, beta 1 (Camurati-Engelmann disease); hypothetical
protein MGC4093
transforming growth factor, beta-induced, 68kDa
transglutaminase 2 (C polypeptide, protein-glutamine-gammaglutamyltransferase)
thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene
homolog, avian)
19
THRSP
thyroid hormone responsive (SPOT14 homolog, rat)
TMEM100 hypothetical protein FLJ10970
TMEM106B hypothetical protein FLJ11273
TMEM7
transmembrane protein 7
TMPRSS2 transmembrane protease, serine 2
TMPRSS3 transmembrane protease, serine 3
TMPRSS4 transmembrane protease, serine 4
TMPRSS5 transmembrane protease, serine 5 (spinesin)
TMPRSS6 transmembrane protease, serine 6
TMPRSS7 transmembrane serine protease 7
TMPRSS9 transmembrane serine protease 9
TNA
tetranectin (plasminogen binding protein)
TNF
tumor necrosis factor (TNF superfamily, member 2)
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TP53I3
tumor protein p53 inducible protein 3
TPMT
thiopurine S-methyltransferase; thiopurine S-methyltransferase pseudogene
TPSAB1;
TPSB2
tryptase alpha/beta 1; tryptase beta 2
TPSD1
tryptase delta 1
TPSG1;
TPSB2;
TPSAB1
tryptase gamma 1; tryptase beta 2; tryptase alpha/beta 1
TUBA3; KALPHA-1 tubulin, alpha 3; tubulin, alpha, ubiquitous
TUBA6
tubulin alpha 6
TUBB;
TUBB2
tubulin, beta polypeptide; tubulin, beta polypeptide 2
UCP1
uncoupling protein 1 (mitochondrial, proton carrier)
UCP2
uncoupling protein 2 (mitochondrial, proton carrier)
UCP3
uncoupling protein 3 (mitochondrial, proton carrier)
UGCG
UDP-glucose ceramide glucosyltransferase
UGT1A3;
UGT1A6;
UGT1A7;
UGT1A1;
UGT1A8;
UGT1A9; UDP glycosyltransferase 1 family, polypeptide A3; UDP glycosyltransferase 1
UGT1A4; family, polypeptide A6; UDP glycosyltransferase 1 family, polypeptide A7; UDP
UGT1A10; glycosyltransferase 1 family, polypeptide A1; UDP glycosyltransferase 1 family,
UGT1A5
polypeptide A8; UDP g
UGT2A1
UDP glycosyltransferase 2 family, polypeptide A1
UGT2B10 UDP glycosyltransferase 2 family, polypeptide B10
UGT2B11 UDP glycosyltransferase 2 family, polypeptide B11
UGT2B17 UDP glycosyltransferase 2 family, polypeptide B17
UGT2B28 UDP glycosyltransferase 2 family, polypeptide B28
UGT2B4;
FLJ21934 UDP glycosyltransferase 2 family, polypeptide B4; hypothetical protein FLJ21934
20
UGT2B7
UGT8
UNQ9391
USP15
VDR
VEGF
VEGFB
VEGFC
VIL1
WBSCR14
WNT1
WNT10A
WNT10B
WNT11
WNT16
WNT2
WNT2B
WNT3
WNT3A
WNT4
WNT5A
WNT5B
WNT6
WNT7A
WNT8A
WNT8B
WNT9A
WNT9B
XPNPEP2
ZBTB16
ZCCHC6
ZCWCC2
ZFP1
ZYX
UDP glycosyltransferase 2 family, polypeptide B7
UDP glycosyltransferase 8 (UDP-galactose ceramide galactosyltransferase)
tryptophan/serine protease
ubiquitin specific protease 15
vitamin D (1,25- dihydroxyvitamin D3) receptor
vascular endothelial growth factor
vascular endothelial growth factor B
vascular endothelial growth factor C
villin 1
Williams Beuren syndrome chromosome region 14
wingless-type MMTV integration site family, member 1
wingless-type MMTV integration site family, member 10A
wingless-type MMTV integration site family, member 10B
wingless-type MMTV integration site family, member 11
wingless-type MMTV integration site family, member 16
wingless-type MMTV integration site family member 2
wingless-type MMTV integration site family, member 2B
wingless-type MMTV integration site family, member 3
wingless-type MMTV integration site family, member 3A
wingless-type MMTV integration site family, member 4
wingless-type MMTV integration site family, member 5A
wingless-type MMTV integration site family, member 5B
wingless-type MMTV integration site family, member 6
wingless-type MMTV integration site family, member 7A
wingless-type MMTV integration site family, member 8A
wingless-type MMTV integration site family, member 8B
wingless-type MMTV integration site family, member 9A
wingless-type MMTV integration site family, member 9B
X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
zinc finger and BTB domain containing 16
zinc finger, CW type with coiled-coil domain 2
zinc finger protein 1 homolog (mouse)
zyxin
21
Supplementary Figure 1.
Genotype case-control test p-values of matched vs. unmatched analysis
for the top 500 SNPs (selection based on p_min) in the candidate gene
study.
In the comparison of the matched and unmatched analyses, 464 of the top 500 ranked SNPs
from both analyses were included in both lists, showing strong agreement between the
matched and unmatched analysis. Supplementary Figure 1 shows the log p-value (minimum
of the two genotype case-control tests including/excluding intermediates) of the matched and
unmatched analyses for the top 500 SNPs, selected on the basis of the minimum p-value of
all 6 single locus analyses. The majority of SNPs show good concordance between matched
and unmatched analyses.