Download 4-YEAR DEGREE PROGRAMME I BIOCHEMISTRY YEAR I A

4-YEAR DEGREE PROGRAMME I BIOCHEMISTRY
YEAR I
A. Faculty & University Requirement
Compulsory Courses
Course Code
FSC 101
FSC 102
FSC 103
FSC 104
FSC 105
GST 105
Title Units
Introductory Biology
Introductory Chemistry
Introductory Computer Science
Introductory Mathematics
Introductory Physics
Use of English I
3
3
3
3
3
2
Total 17
B. Other Requirements for Biochemistry Majors
Compulsory Course
Course Code
BCH 102/CHM 101
BCH 103/CHM 102
BCH 101/BTN 101
or
BCH 106/ZLY 101
BCH 105/PHS 101
or
BCH 104/MAT 102
GST 106
Title Units
Introductory Chemistry II
Experimental Chemistry I
General Biology I
4
2
3
General Biology II
Introductory Physics II
3
2
Calculus
Use of English II
2/3
2
Total 13/14
C. Optional
PHS 102
PHS 103
Introductory Physics III
Practical Physics
3
2
Course selection at this level
1. All students must register for all FSC courses in the first semester.
2. All Biochemistry majors must register for all compulsory courses for majors in the
second semester in addition to any optional course to meet semester requirement.
YEAR II
A. Compulsory for Biochemistry Majors
Course Code
Title
BCH 201
Introductory Biochemistry (A)
BCH 205/CHM 203
Basic Organic Chemistry
BCH 206/CHM 204
Experimental Chemistry II (Physical & inorganic)
GAS 201
General African Studies
BCH 202
Introductory Biochemistry (B)
BCH 203/BIY 201
Cell Biology
BCH 204/CHM 202
Basic Physical Chemistry
BCH 207/CHM 205
Experimental Chemistry III (Organic)
GAS 202
General African Studies
Total 23
B. Optional
Course Code
Title
CHM 201
Basic Inorganic Chemistry
PHS 202
Thermodynamics
ZLY 201
General Invertebrate Zoology
BIY 202/MIC 202
Introductory Development Biology
BIY 203
Introduction to the Biology of Micro organisms.
MAT 213
Pure Mathematics I
ZLY 202
Vertebrate Zoology
BIY 227
Plant Physiology
BIY 210
Biological Techniques
PHS 204
Modern Physics II
PHS 205
Oscillation & Waves
PHS 207
Optics
MIC 201
Introductory Microbiology
Units
2
4
2
2
2
3
4
2
2
Units
4
2
3
2
2
2
3
2
2
2
2
2
2
Courses can be selected from section B or other subject areas to meet the degree
requirements.
YEAR III
A. Compulsory for Biochemistry Majors
Course Code
Title
BCH 301
Chemistry of Macromolecules I (Protein & Nucleic acid).
BCH 302
Chemistry of macromolecules II
BCH 303
(Carbohydrates Lipid & Membrane)
BCH 307
Techniques in Biochemical Research
BCH 311/CHM 304 Organic reactions
BCH 312/CHM 306 Chemical Thermodynamics
BCH 313/CHM 314 Experimental Chemistry V
FSC 301
History & Philosophy of Science
Total
Units
2
2
2
2
3
2
2
2
17
BCH 304
BCH 305
BCH 306
BCH 309
FSC 302
Intermediary Metabolism
Experimental Biochemistry II
Introductory Enzymology
Introductory Molecular Biology
Language (French/German)
Total
3
2
2
2
2
11
Elective: At least 4 units including MAT 317.
Course Code
Title
MAT 317
Statistics for Biologists
BCH 308
Basic immunology
BCH 300
General Biochemistry (Non-Majors)
BCH 310
Biochemical Pharmacology
ZLY 307
Comparative Animal Physiology
BIY 302
Genetics
ZLY 310
Animal behaviour
Units
3
2
3
2
4
2
2
OTHERS
Course Code
CHM 303
CHM 305
CHM 307
CHM 308
CHM 313
Units
2
2
2
2
2
Title
Methods of Chemical Analysis
Applied Spectroscopy
Chemical Kinetics
Electrochemistry
Expt. Chemistry IV (Physical Inorganic)
Courses can be selected from section B to meet the degree requirements.
YEAR IV
A. Compulsory for Biochemistry Majors
Course Code
Title
BCH 401
Chemistry of Bio-polymer
BCH 402
Mechanism of Enzyme Action
BCH 403
Metabolism & Regulation
BCH 405
Experimental Biochemistry III
BCH 408
Seminars & Biochemical Literature
BCH 409
Bio membranes
BCH 404
Biochemical Genetics
BCH 420
Project
Total 19
B. Electives: At least 12 units selected from
Course Code
Title
BCH 407
Nutritional Biochemistry
BCH 417
Biochemistry of Viruses
Units
3
3
3
2
2
2
2
4
Units
2
1
BCH 406
BCH 410
BCH 411
BCH 412
BCH 413
BCH 414
BCH 415
BCH 416
BCH 417
Biochemistry of hormones
Plant Biochemistry
Introduction to Biotechnology
Food Biochemistry
Advanced Immunology
Biochemistry of Parasites
Clinical Biochemistry
Biochemistry of selected organs & tissues
Biochemistry of viruses
2
2
2
2
2
2
2
1
1
Courses can be selected from section B or other subject areas to meet the degree
requirement.
COURSE DESCRIPTIO
200 Level Courses
BCH 201:
Introduction Biochemistry I
2 Units
Prerequisite: BCH 102, BTN 101 or ZLY 101.
General considerations on the biological molecules of life (protein, carbohydrates, lipid,
nucleic acid). General properties of enzymes as biological catalysts. Buffer and Buffer
systems. Energy generation and storage in biological systems.
Text:
(i) Harper, H.A. Review of Physiological Chemistry.
(ii) Karlson P. Introduction to Modern Biochemistry.
BCH 202:
Introductory Biochemistry II
2 Units
Prerequisite: BCH 201
Introduction of Metabolism and bioenergetics.
Breakdown of biological molecules and their uses as fuels. Biological oxidation: Electron
transport Chain, Phosphorylation, Physiological functions of hormones, Vitamins and cofactors, their importance in nutrition and metabolism. Unit and diversity in biochemistry.
Text:
(i) Harper, H.A. Review of Physiological Chemistry.
(ii) Karlson, P. Introduction to Modern Biochemistry (Academic Press).
(iii) Conn & Stumpf. Outlines of Biochemistry. (Wiley & Sons).
300 Level Courses
BCH 300:
General Biochemistry (on-Majors)
3 Units
General outlines of basic chemistry of biological Polymers, carbohydrates, proteins,
lipids, nucleotides and polynucleotides.
Elementary enzyme kinetics. Metabolism of lipids, amino acids and proteins. Metabolism
of Carbohydrates, Glycolysis, TCA, etc Vitamins & cofactors. Special topics to include
photosynthesis, hormones (plant & animal) detoxification mechanisms.
Text:
(i) Conn & Stumpf. Outlines of Biochemistry.
(ii) Sutie, J. W. Introduction to Biochemistry.
(iii) Lehninger A. Principles of Biochemistry.
BCH 301:
Chemistry of Macromolecules
2 Units
Prerequisite: BCH 201, BCH 202, CHM 203
General study of chemistry of proteins and nucleic acids. Functions of proteins, amino
acid composition of proteins structure and properties. Classification of proteins based on
solubility and structural organisation, determination of primary structure of proteins; N
terminal and C terminal amino acids determination. Structure function-relationship of
named proteins. Denaturation of proteins etc. Function of nucleic acids, evidence for
DNA as genetic material, primary structure of nucleic acids, structure of RNA & DNA.
Properties of DNA in solution. Degradation of nucleic acids and sequencing of DNA.
Texts:
(i) Stryer, L. Biochemistry.
(ii) Lehninger, A. Principles of Biochemistry.
(iii) Wood, Wilson, Benbow & Wood.
Biochemistry: A problem approach.
(iv) McGilvery, R. W. Biochemical Concept.
BCH:
302 Chemistry of Macromolecules II
2 Units
Prerequisite: As for BCH 301
A general study of the Chemistry of Carbohydrates and lipids, including membrane
lipids, including membrane lipids: classification and nomenclature of carbohydrates.
Stereochemistry of carbohydrates, chemical reactions of carbohydrates, chemistry of
polysaccharides.
Text: As for BCH 301
BCH 303:
Experimental Biochemistry I
2 Units
Prerequisite: As for BCH 302 and CHM 304
Buffer and buffer systems, pH indicators. Measuring techniques in Biochemistry cell
fraction extraction, analysis and partial characterisation of macromolecules. Basic
chromatographic techniques; approach for characterisation of macromolecules.
BCH 304:
Intermediary Metabolism
3 Units
Prerequisite: BCH 302
Detailed metabolism of Carbohydrates and lipids, Gluconeogensis. Glyoxylate cycle.
Hexosemono-phosphate shunt, fatty acid and triglyceride oxidation.
Fatty acid and triglyceride synthesis, detailed treatment of the metabolism of amino acids
degradation and biosynthesis; inborn errors of metabolism.
Nucleoside, nucleotide and nucleic acid synthesis. One carbon metabolism,
Transmethylation. Protoporphyrin Synthesis in animals and plants. Hormones and
regulatory role in intermediary metabolism.
Text: As for BCH 301
BCH 305:
Experimental Biochemistry II
2 Units
Prerequisite: As for BCH 304
An introduction into methods of study of intermediary metabolism. Experimental
approaches, synthesis of lipids, carbohydrate protein metabolism, lipid metabolism
nucleic acid, metabolism, Electron transport and oxidative phosphorylation.
Text:
Bruening, G. Biochemical Experiments. Criddel, R.
BCH 306:
Introduction to Enzymology
2 Units
History of Enzymology, definition, enzyme as catalyst, general characteristics,
nomenclature, nature of enzymes. Levels of structural organisation; active site, nature of
active site, enzyme kinetics, analytical enzymes - isolation, purification and
characterisation of enzymes and measurement of enzyme activity - methods and
principles.
Text:
(i) Fersht. Enzyme structure & mechanism.
(ii) Cornish-Bowden. Fundamentals of Enzyme Kinetics.
(iii) Dawes, E.A. Quantitative Problem Biochem.
BCH 307:
Techniques in Biochemical Research
2 Units
Prerequisite: CHM 205
Separation techniques in biochemistry. The Principles, procedures, and application of
centrifugation, chromatographic separation and analytical techniques. The principles,
instrumentation, and application of manometric, spectrofluorimetric spectrophotometric
and radioisotope and analytical techniques.
Text:
(i) Cooper, T.G. Tools of Biochemistry. John Wiley & Sons N.Y.
(ii) Stock, R. & Rice, C.B.F. Chromatographic Methods. Chapman & Hall Ltd, London.
BCH 308:
Basic Immunology
2 Units
Prerequisite: BCH 301, BCH 302
Basic immunobiology, Antigens, antibodies and their reactions.
Classification and structural motifs of immunoglobulins.
Antibody combining sites and structure function relationship complement system and
fixation, organisation of immunoglobulin genes. Molecular basis of antibody diversity.
Production, detection and uses of monoclonal antibodies. Concepts of clinical
immunology; immune tolerance factors affecting immune response.
Text: Roitt: Essential Immunology (Blackwell Scientific publications).
BCH 309:
Introductory Molecular Biology
Prerequisite: BIY 201; BCH 301/BCH 302
2 Units
A study of the structure and function of the genetic material in relation to genetic
expression and control in prokaryotes and eukaryotes, including Cellular ultra structure:
Chromosome structure and Gene expression:
Text:
(i) Haggis, G.K. Introduction to Molecular Biology. (Longmans London).
(ii) Hood, Wilson & Wood.
Molecular Biology of Eukaryotic cells.
Benjamin/Cummings Pub. Coy.
BCH 310:
Biochemical Pharmacology
2 Units
Prerequisite: BCH 301, BCH 302
Introduction to pharmacological concepts. Emphasis on drug metabolism and drug
interactions
Ref: Mayer, Jawette & Goldher. Review of Medical Pharmacology.
BCH 401:
Chemistry of Biological Polymers
2 Units
Prerequisite: BCH 301, BCH 302
A comprehensive study of the structure and physico-chemical properties in solution of
bio molecules. Amino acid structure and properties, primary structure of protein
conformation and methods of analysis. Protein structure - function relationship. Review
of Nucleic acid structure, nucleoproteins and nucleic acid isolation properties and
conformation, polynucleotide sequencing, Polysaccharide and lipid structure, properties
and analysis. Structural features of protoglycans, peptidoglycans, lipo-proteins and
lipopolysaccharides. Membrane structure and integrity.
Text:
(i) Lehninger, A. L. Principles of Biochemistry.
(ii) Stryer, A.L. Biochemistry.
(iii) Baker, R. Organic chemistry of biological compounds.
BCH 402:
Special Topics in Enzymology
2 Units
Prerequisite: BCH 306
Enzyme structure and properties, structure of enzymes, enzyme assemblages, enzyme
kinetics, principles of catalysis, multienzyme systems, allosterism, enzyme inhibition.
Regulation of enzyme activity; chemical modification of enzyme activity, enzyme
reaction mechanism.
Text:
(i) Fersht. Enzyme Structure & Mechanism
(ii) Cornish-Bowden. Fundamentals of Enzyme Kinetics.
(iii) Dawes, E.A. Quantitative Problem in Biochemistry.
BCH 403:
Advanced Intermediary Metabolism and Regulation
3 Units
Prerequisite: BCH 304
Advanced studies in degradation and synthesis of biological compounds. Carbohydrate
degradation and synthesis and regulatory processes. Lipid, protein, purines and
pyrimidine degradation and synthesis and regulatory process. Endocrine system and
mechanism of hormone control of metabolism.
Text:
(i) Larner, J. Intermediary metabolism.
(ii) Stryer. Biochemistry.
(iii) Lehninger, A.L. Principles of Biochemistry.
BCH 404:
Biochemical Genetics
2 Units
Prerequisite: BCH 309
A more comprehensive study of the pathway of biological information transfer processes
comprising detailed analysis of replication, transcription and translation. Mechanism of
infection by virus.
Recombinant - DNA and gene cloning, extra - chromosomal factors, plasmids, episomes.
Text:
(i) Lehninger, A.L. Principles of Biochemistry.
(ii) Stent & Cleender. Molecular Genetics.
(iii) Woods, R.A. Biochemical Genetics. Outlines Studies in Biology.
(iv) Stryer, L. Biochemistry.
(v) Watson, J.D., Hopkins, N.H., Roberts, J.H., Steitz, J.A. and Weiner, A.M.
Molecular Biology of the gene.
BCH 405:
Experimental Biochemistry III
2 Units
Prerequisite: Any two from BCH 303, BCH 305, BCH 307
Sets of experiments in Biochemistry to supplement BCH 401 BCH 402 & BCH 403.
The course is designed to test student's ability in the use of biochemical literature and
their ability to do simple experiments and interpret the resulting data (18
hours/week).
BCH 406:
Biochemistry of Hormones
2 Units
Prerequisite: BCH 403
Evolution of hormone action, classes of hormones, intracellular mediators of hormone,
hormone receptors, binding activity and response. Kinetics of binding, mode of action of
hormones, camp as second messenger, role of calcium and other ions. Amino acid
derived hormones, steroid hormones and polypeptide hormones. Hormone agonists,
antagonists and partial agonists.
Text:
(i) Lehninger, A.L. Principles of Biochemistry.
(ii) Bhagavan, N.V. Biochemistry: A comprehensive Review.
BCH 407:
utritional Biochemistry
2 Units
Prerequisites: BCH 301, 302 and BCH 304
Body composition, nutrients required by man and factors affecting the requirements.
Foodstuff and their energy values and protein quality, food preservation and processing,
food habits and intakes. Digestion, absorption, metabolism and function of carbohydrates,
lipid, proteins and amino acids in man. Consequences of excess and inadequate calorie
intake, protein-energy malnutrition. The vitamins, chemistry, metabolism and function,
the minerals, metabolism and function. Animal and microbial nutrition. Feed formulation,
food toxicants and detoxification mechanisms.
Text:
(i) Stryer, L. Biochemistry.
(ii) Pike, R.L. and Brown, M.L. 4utrition, "An integrated approach".
(iii) Freedland and Briggs. A biochemical approach in 4utrition.
BCH 408:
Seminars & Biochemical Literature
2 Units
Prerequisite: Any five from BCH 301 to BCH 309
Course to cover reading assignments to students which are expected to be completed
during 3-6 hours library studies and later presented as short Seminars. One lecture weekly
on growth and development of Biochemistry emphasizing major breakthrough in
Biochemical research.
BCH 409:
Bio membranes
2 Units
Prerequisite: BCH 302
Definition, list of functions and membrane types; membrane composition: - Lipid
structure, properties and formation of the bilayer; protein and carbohydrates. Membrane
asymmetry and movements, diffusion, rotation and fluidity. Isolation and identification,
electron microscopy and marker enzyme assays. Introduction to receptor function: antigenicity of membrane components. Cell membranes and toxins, transport processes,
mode of action of polymyxin and ionophores antibiotics. Introduction to
neurotransmission.
Text:
(i) Chairbone and Weissman. Biology of cell membrane.
(ii) Fox, C.F. & Keith, A. Membrane molecular biology.
BCH 410:
Plant Biochemistry
2 Units
Prerequisite: BCH 301, BCH 304
General description of sub cellular components of plant cell and methods of fractionation;
Structure of primary cell wall. Complex carbohydrates of plants. Chemistry and
metabolism. Autotrophy (Photosynthesis) Selected Topics in lipid metabolism. Aspects
of nitrogen metabolism in plant. Mineral metabolism. Plant hormones.
Text: Bonner, J. & Verner, J.E. (Ed). Plant Biochemistry.
BCH 411:
Introduction to Biotechnology
2 Units
Prerequisite: BCH 309
Introduction: Biochemistry of microbial growth, energetics and Kinetics of microbial
growth. Down stream processing in Biotechnology and general instrumentation.
Fermentation of Food related products. Microbial gums and other polymers. Enzyme
production: immobilised enzymes and applications. Pollution control, genetic
engineering; application in Biotechnology.
Text: Wisseman, A. (Ed). Principle of Biotechnology.
BCH 412:
Food Biochemistry
2 Units
Prerequisites: BCH 301/302; BCH 304
Course covers biochemical changes in food - meat, fish, and fruits. Enzymatic browning
and bio deterioration of food products - vegetable and oils, milk & milk products, cereal
formulas and food additives.
Text:
(i) Bell, Smith & Paterson. Textbook of Physiology and Biochemistry (9th edition Livingstone).
(ii) Smith, B. Textbook of Chemistry. (Avis Publication, 1975).
BCH 413:
Advanced Immunology
2 Units
Prerequisite: BCH 302 BCH 304, BCH 308
This course covers the fundamentals of clinical immunology and mechanisms of
immunopathology. Tissue reactions of injury, allergic disease and cancer immunology.
Text: Alexander, J.W. and Rover, A. Good. Fundamentals of Clinical Immunology.
BCH 414:
Biochemistry of Parasites
2 Units
Prerequisite: BCH 301, BCH 302, BCH 304
Metabolism of bio molecules in parasites contrasted with that of the host, Host/parasite
interaction, and parasite nutrient needs. Biochemical mechanisms of drug action against
parasitism. Defence mechanism in parasitism. Bio membranes of parasites.
Text:
(i) W.E. Gutheridge, W.E. & Coombs, G.H.Q. Biochemistry of parasitic protozoa.
(ii) Michael, F. Modern Genetic concepts and Techniques in the study of parasites.
(iii) Hoelzi Wallach, D.F. The membrane pathobiology of Tropical diseases.
BCH 415:
Clinical Biochemistry
2 Units
Prerequisite: BCH 303, BCH 305
Course covers the theoretical biochemical basis of laboratory tests of clinical significance
in diagnosis and management of diseases.
Text: Curtius, B.S. & Roth Marc. Clinical Biochemistry & Principles methods, Vol. II .
Walter De Gruyter, 1974.
BCH 416:
Biochemistry of Selected Organs and Tissues
1 Unit
Prerequisite: BCH 301, BCH 302
Intracellular organisation, structure and functions of specialised tissues - liver, kidney
muscles, adipose tissue, elastin, collagen, brain, Functional aspects of neural
biochemistry membrane potential and ion transport. Neurotransmitters and biogenic
amines in the brain. Constitution and function of blood, lymph and other fluids.
Biochemistry of vision.
BCH 417:
Biochemistry of Viruses
1 Unit
Prerequisite: BCH 301, BCH 309
Survey of structural properties of different classes of viruses. Viral multiplication
mechanisms. Control of viral replication. Interferon.
Text: Styer. Biochemistry.
BCH 420:
Project
4 Units
Prerequisites: Any two from BCH 303, BCH 305, BCH 307,
Literature survey and planned laboratory work to be written up as a project under the
supervision of a member of staff.