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Transcript
A Lipid-Clustering Mechanism to Trigger Actin Assembly in Cell Extracts Paul A. Janmey and Dennis Discher Filaments in the cytoplasm that constitute a three dimensional cytoskeleton are formed by polymerization of the protein actin, which is initiated at distinct sites near the cell membrane. Negatively charged lipids in the membrane corm clusters when intracellular calcium increases, and these lipid clusters activate proteins that initiate actin assembly. Support: Primary NSF MRSEC DMR-11-20901 80 nm
