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Download SOMAmer® anti-Interleukin-6 receptor subunit alpha
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SOMAmer® anti-Interleukin-6 receptor subunit alpha Reagent DESCRIPTION SOMAmer Reagent No. Protein Target Target UniProt ID Species Reactivity 5’ Functional Mod. Target Source Formulation B-4139-71_2 Interleukin-6 receptor subunit alpha P08887 Human Biotinylated Synthetic Oligonucleotide R&D Systems®, PN 227-SR-025/CF Buffered SOMAmer reagent delivered at 10 μM in 5 mM HEPES, 1 mM EDTA, pH 8 ACTIVITY SOMAmer reagents have been qualified for target affinity capture in conjunction with numerous downstream applications. Specific protocols should be determined for the intended use. General application notes are available on our website (http://www.somalogic.com/resources/app-notes/). Specificity No closely related human proteins were available for specificity testing. Affinity The Kd for Interleukin-6 receptor subunit alpha binding to the SOMAmer -11 reagent, measured by Zorbax Affinity method, is typically 1 x 10 M. See Certificate of Analysis for details. HANDLING and STORAGE Handling Shipping Stability & Storage Heat/cool treatment on material ready for use (not stocks) is recommended (e.g. heat the reagent to 95 °C for 5 minutes, then cool to assay temperature). The product is shipped frozen. Upon receipt, store it immediately at the temperature recommended below. For long term use, aliquotting is recommended to avoid freeze-thaw cycles. 2 years from date of receipt at -20 °C to -70 °C, as supplied 3 months at 4 °C TARGET FUNCTION Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity. (Source: The UniProt Consortium, Activities at the Universal Protein Resource (UniProt), Nucleic Acids Res. 42: D191-D198 (2014).) SomaLogic, Inc. • 2945 Wilderness Place Boulder, CO 80301 • www.somalogic.com Technical Support 800-324-0783 • Main Number 303-625-9000 570-00006, Rev 0, DCN 15-326 Effective Date: 10/5/2015 2015 SomaLogic, Inc.
