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SoonChunHyang University:
SoonChunHyang Institute of Medi-Bio Science (SIMS)
4661 – Advanced Molecular Biology I (3 units)
Spring 2016
Course Director : Youngjo Kim and Jaeseok Han
Email: [email protected], [email protected]
Course Description : The course objective is to consider both principles and current
topics in Molecular Biology in depth. This course primarily deals with nucleic acids and
proteins and how these molecules interact within the cell to promote proper growth,
division, and development. Especially this course will emphasize the molecular
mechanisms of DNA replication, repair, transcription, protein synthesis, and gene
regulation in different organisms. Students are expected to learn the basic concepts and
experimental techniques used to discern these mechanisms, referring to text book and
the original scientific articles, respectively. Reading assigned textbook is strongly
recommended for this course.
Course requirement : Each class consists of the lecture by the instructor and in class
discussion. Therefore, class attendance is required to participate in the discussion.
Students will prepare a presentation to be given during class. Original research articles
relevant to the topics of each class will be posted ahead of the class.
Grading Procedure : The final grade is based on class attendance (10%), class
participation (20%), midterm exam (30%), and the final exam (40%).
Class Schedule
Weeks
Topic
1
Introduction to course, A brief history
2
Nucleic acids, proteins and analysis tools
3
Methods in Molecular Biology
4
DNA replication, DNA damage and repair
5
DNA replication II: Detailed Mechanism
Weeks
Topic
6
Homologous recombination
7
Introduction to Genomics
8
Midterm exam
9
Eukaryotic transcription I
10
Eukaryotic transcription II
11
Chromatin structure & its effects on transcription
12
RNA processing
13
Post-transcriptional control of gene expression
14
Translation I
15
Translation II
16
Final exam