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Circulatory System Words to Know The circulatory system is responsible for delivering food, oxygen, and other needed substances to all cells in all parts of the body while taking away waste products. The basic components of the circulatory system are the heart, the blood vessels, and the blood. As blood circulates around the body, it picks up oxygen from the lungs, nutrients from the small intestine, and hormones from the endocrine glands, and delivers these to the cells. Blood then picks up carbon dioxide and cellular wastes from cells and delivers these to the lungs and kidneys, where they are excreted. The circulatory system is also known as the cardiovascular system, from the Greek word kardia, meaning “heart,” and the Latin vasculum, meaning “small vessel.” The Human Heart In humans, the adult heart is a hollow cone-shaped muscular organ located in the center of the chest cavity. The heart is about the size of a clenched fist and weighs approximately 10 ounces (300 grams). A heart beats more than 100,000 times a day and close to 2.5 billion times in an average lifetime. The pericardium—a triple-layered sac—surrounds, protects, and anchors the heart. The heart is divided into four chambers (see figure 2). A septum, or partition, divides it into a left and right side. Each side is further divided into an upper and lower chamber. The upper chambers, the atria (singular atrium), are thin-walled. They receive blood entering the heart and pump it to the ventricles, the lower heart chambers. The walls of the ventricles are thicker and contain more cardiac muscle than the walls of the atria. These muscles enable the ventricles to pump blood out to the lungs and the rest of the body. Artery A blood vessel that transports oxygenated blood away from the heart to bodily tissues. Atrium Receiving chamber of the heart. Capillary A microscopic blood vessel that transports blood to and from tissues. Hormone A chemical produced by a cell or tissue that sends a message to another part of the body, directing it to act a certain way. Vein A blood vessel that transports deoxygenated blood away from bodily tissues back to the heart. Ventricle Pumping chamber of the heart. Figure 2 Figure 1 1 The left and right sides of the heart function as two separate pumps. The right atrium receives blood carrying carbon dioxide from the body through a major vein, the vena cava, and delivers it to the right ventricle. The right ventricle, in turn, pumps the blood to the lungs via the pulmonary artery. The left atrium receives the oxygen-rich blood from the lungs through the pulmonary veins, and delivers it to the left ventricle. The left ventricle then pumps it into the aorta, the major artery that leads to all parts of the body. The wall of the left ventricle is thicker than the wall of the right ventricle, making it a more powerful pump able to push blood through its longer trip around the body.One-way valves in the heart keep blood flowing in the right direction and prevent backflow. The valves open and close in response to pressure changes in the heart. In the heart, the two atria contract while the two ventricles relax. Then, the two ventricles contract while the two atria relax. Blood Vessels The blood vessels of the body (arteries, capillaries, and veins) make up a closed system of tubes that carry blood from the heart to tissues all over the body and then back to the heart. Arteries carry blood away from the heart, while veins carry blood toward the heart. Large arteries leave the heart and branch into smaller ones that reach out to various parts of the body. These divide still further into smaller vessels called arterioles that penetrate the body tissues. Within the tissues, the arterioles branch into a network of microscopic capillaries. Substances move in and out of the capillary walls as the blood exchanges materials with the cells. Before leaving the tissues, capillaries unite into venules, which are small veins. The venules merge to form larger and larger veins that eventually return blood to the heart. The walls of arteries, veins, and capillaries differ in structure. In all three, the vessel wall surrounds a hollow center through which the blood flows. The walls of both arteries and veins are composed of three coats, but they differ in thickness. One-way valves in the walls of veins keep blood flowing in one direction. The walls of capillaries are only one cell thick. Of all the blood vessels, only capillaries have walls thin enough to allow the exchange of materials between cells and the blood. Blood Blood is liquid connective tissue. It transports oxygen from the lungs and delivers it to cells. It picks up carbon dioxide from the cells and brings it to the lungs. It carries nutrients from the digestive system and hormones from the endocrine glands to the cells. It takes heat and waste products away from cells. It protects the body by clotting and by fighting disease through the immune system. Blood is composed of plasma (liquid portion) and blood cells. Plasma, which is about 91.5 percent water, carries blood cells and helps conduct heat. The three types of cells in blood are red blood cells (erythrocytes), white blood cells (leukocytes) and platelets (thrombocytes). More than 99 percent of all the blood cells are red blood cells. They contain hemoglobin, a red pigment that carries oxygen, and each red cell has about 280 million hemoglobin molecules. White blood cells fight disease organisms by destroying them or by producing antibodies that disable or kill them. Platelets bring about clotting of the blood. "Circulatory System." UXL Encyclopedia of Science, edited by Amy Hackney Blackwell and Elizabeth Manar, 3rd ed., UXL, 2015. Research in Context, go.galegroup.com/ps/i.do?p=MSIC&sw=w&u=pioneer&v=2.1&id=GALE%7CCV2644300256&it=r&asid=09a3fc4eede9348d0ed11730175ed617. Accessed 24 Feb. 2017. 2